Abstract：
PURPOSE:This study aimed to test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity. METHODS:Fourteen adolescents with obesity were assigned to 6 wk of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained three times per week for 50-60 min, including endurance and resistance exercises. Oral glucose tolerance test, blood and morphological analyses, and physical performance tests were performed before and after the training period. RESULTS:After training, hypoxia, but not normoxia, decreased the area under the curve of plasma insulin (-49%; P = 0.001) and glucose levels (-14%; P = 0.005) during oral glucose tolerance test. Decreased plasma triglycerides levels (P = 0.03) and increased maximal aerobic power (P = 0.002), work capacity at 160 bpm (P = 0.002), and carbohydrate consumption during exercise (P = 0.03) were measured only in the hypoxic group. CONCLUSIONS:Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
DE Groote E,Britto FA,Bullock L,François M,DE Buck C,Nielens H,Deldicque Ldoi
10.1249/MSS.0000000000001694subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2200-2208issue
11eissn
0195-9131issn
1530-0315journal_volume
50pub_type
杂志文章,随机对照试验abstract：:The ventilatory stimulating effects of hypoxia occurring at carotid bodies are potentiated by exercise. However, hypoxia also has central ventilatory depressive effects; the potential interactions between this hypoxic depression and exercise have not been studied. We examined the ventilatory response to a 20 min perio...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:Regression analysis is often used to demonstrate associations among variables believed to be biologically related. Failure to demonstrate a "significant" relationship may be due to two factors: 1) the variables are truly unrelated, or 2) a relationship exists but goes undetected due to inadequate statistical power. In...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：PURPOSE:This prospective magnetic resonance (MR) imaging study investigated the development of symptomatic pars lesions in the lumbar spine of adolescent cricket fast bowlers. METHODS:Annual MR examinations of the lumbar spine in male fast bowlers (N = 51) and swimmers (N = 20) without a prestudy history of symptomati...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000241642.82725.ac
更新日期：2007-01-01 00:00:00
abstract：:During exercise, especially endurance exercise in the heat, vital body fluids and essential ions are lost in sweat, and the body may deplete its glycogen stores. Unless essential body fluids are restored, these conditions can produce hypovolemia, hypoglycemia, hyponatremia, hyperthermia, and dehydration. Performance m...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1992-06-01 00:00:00
abstract：PURPOSE:Supplementation with inorganic nitrate has been suggested to be an ergogenic aid for athletes as nitric oxide donor. The purpose of this study was to determine whether ingestion of inorganic sodium nitrate benefits well-trained athletes performing a 40-min exercise test in laboratory conditions. In addition, we...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3182687e5c
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Resting cardiac vagal modulation (RCVM) and postexercise vagal reactivation (PEVR) are markers of parasympathetic activity. We investigated whether adaptations in these markers to aerobic training are influenced by baseline autonomic control. METHODS:Forty healthy men (19.2 ± 0.8 yr) of similar cardiorespirato...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000000532
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Hyperventilation increases the clearance of carbon monoxide (CO) from blood; thus, we hypothesized that CO elimination would be enhanced with exercise. Accordingly, this study examined the effect of exercise on the half-life of carboxyhemolobin elimination. METHODS:Six healthy subjects (three males and three f...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3182602a00
更新日期：2012-11-01 00:00:00
abstract：:The relationships between individual performance and lactate exchange and removal abilities were studies in 12 male rowers all subjected to three measurements on a rowing ergometer. An incremental exercise carried out to determine the maximal oxygen uptake (VO2max) and the corresponding maximal aerobic power (Pamax), ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199703000-00016
更新日期：1997-03-01 00:00:00
abstract：PURPOSE:To evaluate the effects of physical activity on bone mineral density, bone mineral content, and lean mass in postmenopausal, overweight/obese women. METHODS:We conducted a 12-month randomized controlled aerobic exercise intervention versus control in 173 sedentary, overweight/obese, postmenopausal women, aged ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/01.mss.0000227308.11278.d7
更新日期：2006-07-01 00:00:00
abstract：:We present a computer simulation of a two-compartment model of the systemic circulation which demonstrates how this model can be used to understand the mechanism(s) for the maximal exercise cardiac output (Q). The model consists of two parallel vascular channels, the splanchnic channel (all blood draining through the ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：OBJECTIVES:To examine if the associations between motor competence and physical activity and musculoskeletal fitness change over time, whether motor competence is associated with longitudinal trajectories of physical activity and fitness, and mediating pathways among these constructs across early childhood. METHODS:Fo...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002388
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Pedometry methods for collecting data in young populations are advancing, but it is unclear how many days of data are enough for population monitoring. METHODS:Using random-digit dialing, 11,669 5- to 19-yr-olds were recruited into the Canadian Physical Activity Levels among Youth study and mailed a data co...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181b67544
更新日期：2010-03-01 00:00:00
abstract：:We hypothesized that the structure of systemic arteries would be altered following 10-14 wk of hindlimb unloading (tail suspension) in female Sprague-Dawley rats. Tail suspension resulted in atrophy of the soleus muscle (P < or = 0.01) but no significant differences in the mass of the extensor digitorum muscle, heart,...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199710000-00005
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:This is a case study of an aerobically trained, multisport, female athlete (age = 39) diagnosed with stage IIIc human epidermal growth factor receptor 2 positive breast cancer. The focus of the study is on measures of cardiorespiratory fitness (V˙O2peak) through the course of cancer therapy. METHODS:A symptom-...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000987
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Aerobic training (AT) and high-intensity intermittent training (HIIT) reduce arterial stiffness, whereas resistance training (RT) induces deterioration of or no change in arterial stiffness. However, the molecular mechanism of these effects of different exercise modes remains unclear. This study aimed to clarif...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000001567
更新日期：2018-06-01 00:00:00
abstract：:The influence of body weight on the performance in cross-country skiing has been studied by: dimensional analysis of the ratio (R) between the factors of importance to power production (VO2max, acceleration of gravity) and the braking powers, e.g., friction and air resistance; measuring the energy cost of level skiing...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：INTRODUCTION:Parents play a critical role in shaping children's attitudes, beliefs, and behaviors, including those around physical activity and inactivity. Our ability to identify which practices effectively promote children's physical activity and limit inactivity is limited by existing measurement instruments. This p...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31829d27de
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate neuromuscular characteristics and muscle power as determinants of distance running performance. METHODS:Seventeen male endurance athletes performed a 5-km time trial (5K) that included three separate constant-velocity 200-m laps during the course and a maximal 20-m ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199901000-00020
更新日期：1999-01-01 00:00:00
abstract：:Physical activity has been shown to be inversely related to coronary heart disease (CHD). The role of high density lipoprotein (HDL) particles in the process of reverse cholesterol transport may be a link between exercise and the prevention of CHD. The aim of the present study was to evaluate the effects of acute exer...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:In a variety of experimental models, hypoxia causes a shift in substrate use to favor increased dependence on glucose. One explanation for this phenomenon is a selective advantage derived from the increased metabolic economy (more ATP derived per unit oxygen consumed) that results when glucose is oxidized rather than ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181729dd3
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:Previous research identified decreased overall and cardiovascular mortality for National Football League (NFL) players from the 1959-1988 era. The present study explored the mortality risk among recent NFL players who played in an era of heavier linemen and nearly year-round physical conditioning. METHODS:This...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001466
更新日期：2018-03-01 00:00:00
abstract：:This article focuses on sports related spinal cord and nerve injuries, ranging from mild "stinger" syndrome to complete quadriplegia. Particular emphasis is placed on recommendations for return to competition after such injuries. Cervical spinal cord symptoms after a spine injury from contact sports require a more pre...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199707001-00005
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:This study aimed to examine the longitudinal associations of person-related factors with physical activity (PA) behavior in young adults. METHODS:We analyzed longitudinal self-reported time spent in moderate-intensity PA (MPA; 4-7 METs) and vigorous-intensity PA (VPA; >7 METs) from 499 young adults (49% male) ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000126
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:To explore the influence of the epicardial fat (EF) tissue on aspects of heart rate recovery (HRR) and cardiorespiratory fitness (V O2peak) in middle-aged men. METHODS:A cross-sectional analysis of EF thickness was performed on 101 overweight or obese men. The men were categorized into low-EF, moderate-EF, and...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181b8b1f0
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C). PURPOSE:The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and th...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3181659c4d
更新日期：2008-05-01 00:00:00
abstract：:Two studies were conducted to test the validity of an all-out procedure for the assessment of the maximal accumulated oxygen deficit (AOD). Subjects in study 1 (N = 9; VO2max = 57 +/- 3 ml.kg-1.min-1 [+/- SEM]) completed three supramaximal efforts on a cycle ergometer. Exhaustive exercise during an all-out isokinetic ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-02-01 00:00:00
abstract：:The degree of parasympathetic control of resting heart rate (PC) was assessed by measurement of variation in heart period (VHP) during cardiopulmonary synchronization of respiration. Respiratory period was arbitrarily preset and standardized at 7 heart beats (3 beats inspiration, 4 beats expiration). The mathematical ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-198508000-00008
更新日期：1985-08-01 00:00:00
abstract：PURPOSE:The present study assessed the factorial validity and gender invariance of the Social Physique Anxiety Scale (SPAS) using a sample of young adolescents. Existing SPAS 12-item, one- and two-factor and truncated, one-factor (i.e., nine-item and seven-item) measurement models reported in the adult literature were ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000117111.76228.bf
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:This study aimed to quantify the repeated oxygen deficits attained during intermittent endurance exercise by measuring oxygen consumption (V˙O2) and oxygen demand (V˙O2) throughout a simulated roller ski race. METHODS:Eight male elite cross-country skiers (V˙O2peak, 77.4 ± 4.4 mL·kg⋅min) raced a 13.5-km roller...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002209
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Physical activity guidelines recommend at least 150 min of moderate-intensity physical activity (MPA), 75 min of vigorous-intensity physical activity (VPA), or combination of MPA and VPA. However, few epidemiological studies have examined whether the general population can derive equal health benefits from MPA ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001463
更新日期：2018-04-01 00:00:00
