The effects of acute dopamine reuptake inhibition on performance.

Abstract:

INTRODUCTION:Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C). PURPOSE:The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and thermoregulation during prolonged exercise in temperate and warm conditions. METHODS:Eight healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (PLA; 20 mg) or methylphenidate (MPH; Ritalin; 20 mg) 1 h before the start of exercise in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial (TT; PLA18 and MPH18; PLA30 and MPH30) to measure exercise performance. RESULTS:MPH did not influence TT performance at 18 degrees C (P = 0.397). TT was completed 16% faster in MPH30 (38.1 +/- 6.4 min) than in PLA30 (45.4 +/- 7.3 min; P = 0.049). In the heat Tcore was significantly higher at rest (P = 0.009), and throughout the TT in MPH30 (P < 0.018), reaching values above 40 degrees C. Throughout MPH30, heart rates were significantly higher (P < 0.05). CONCLUSIONS:These results show that MPH has a clear ergogenic effect that was not apparent in 18 degrees C. The combination of a dopamine reuptake inhibitor and exercise in the heat clearly improved performance and caused hyperthermia without any change in the perception of effort or thermal stress compared with the PLA trial. This response may potentially increase the risk of developing heat illness during exercise in individuals taking drugs of this nature.

journal_name

Med Sci Sports Exerc

authors

Roelands B,Hasegawa H,Watson P,Piacentini MF,Buyse L,De Schutter G,Meeusen RR

doi

10.1249/MSS.0b013e3181659c4d

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

879-85

issue

5

eissn

0195-9131

issn

1530-0315

journal_volume

40

pub_type

杂志文章,随机对照试验
  • Impact of Moderate-Intensity and Vigorous-Intensity Physical Activity on Mortality.

    abstract:PURPOSE:Physical activity guidelines recommend at least 150 min of moderate-intensity physical activity (MPA), 75 min of vigorous-intensity physical activity (VPA), or combination of MPA and VPA. However, few epidemiological studies have examined whether the general population can derive equal health benefits from MPA ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001463

    authors: Kikuchi H,Inoue S,Lee IM,Odagiri Y,Sawada N,Inoue M,Tsugane S

    更新日期:2018-04-01 00:00:00

  • Body composition in sport and exercise: directions for future research.

    abstract::Body composition has become a major field of interest for many exercise and sport scientists as well as clinicians who specialize in the prevention of and rehabilitation from hypokinetic diseases. This paper discusses the state of the art within selected areas of body composition, identifying significant areas of cont...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Wilmore JH

    更新日期:1983-01-01 00:00:00

  • The Yips: Methods to Identify Golfers with a Dystonic Etiology/Golfer's Cramp.

    abstract:PURPOSE:To determine whether quantitative methods could separate golfers with a possible dystonic cause of the "yips" from those that appear to be nondystonic. METHODS:Twenty-seven golfers completed 10 two-handed and 10 right hand-only putts. Surface EMG assessed forearm muscle co-contraction and motion detectors moni...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001687

    authors: Adler CH,Temkit M,Crews D,McDaniel T,Tucker J,Hentz JG,Marquardt C,Abraham D,Caviness JN

    更新日期:2018-11-01 00:00:00

  • A simple, reliable method of assessing exercise capacity in patients with chronic heart failure.

    abstract:OBJECTIVE:The accurate determination of limitations in physical activity is important in evaluating patients with heart failure and in assessing the efficacy of treatment. However, the conventional measures used to evaluate hemodynamics, functional class, and exercise capacity all have limitations. Our objective was to...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-199901000-00010

    authors: Asakuma S,Fujiwara M,Ohyanagi M,Iwasaki T

    更新日期:1999-01-01 00:00:00

  • Pulmonary Artery Wedge Pressure Relative to Exercise Work Rate in Older Men and Women.

    abstract:PURPOSE:An augmented pulmonary artery wedge pressure (PAWP) response may explain exercise intolerance in some humans. However, routine use of exercise hemodynamic testing is limited by a lack of data from normal older men and women. Our objective was to evaluate the exercise PAWP response and the potential for sexual d...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001227

    authors: Esfandiari S,Wright SP,Goodman JM,Sasson Z,Mak S

    更新日期:2017-07-01 00:00:00

  • Evaluation of the Cosmed K2 portable telemetric oxygen uptake analyzer.

    abstract::The purpose of this study was to determine the validity and evaluate the accuracy of a portable telemetric oxygen uptake analyzer (K2). Two experiments were carried out: a) using a mechanical lung, the accuracy of the K2 to measure oxygen fractions and minute ventilation following 10 and 60 min of warm-up was determin...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Crandall CG,Taylor SL,Raven PB

    更新日期:1994-01-01 00:00:00

  • Assessing sedentary behavior with the GENEActiv: introducing the sedentary sphere.

    abstract:BACKGROUND:The Sedentary Sphere is a method for the analysis, identification, and visual presentation of sedentary behaviors from a wrist-worn triaxial accelerometer. PURPOSE:This study aimed to introduce the concept of the Sedentary Sphere and to determine the accuracy of posture classification from wrist acceleromet...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000000224

    authors: Rowlands AV,Olds TS,Hillsdon M,Pulsford R,Hurst TL,Eston RG,Gomersall SR,Johnston K,Langford J

    更新日期:2014-06-01 00:00:00

  • Physical activity and the initiation of high-risk health behaviors in adolescents.

    abstract::The association of physical activity to the initiation of health risk behaviors was examined in a 3-yr prospective study of a population-based cohort of 1245 adolescents aged 12-16 yr. Four hundred thirty-seven students (35% of the cohort) were identified at baseline via self-report survey as never having smoked cigar...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Aaron DJ,Dearwater SR,Anderson R,Olsen T,Kriska AM,Laporte RE

    更新日期:1995-12-01 00:00:00

  • Effects of shoes and foot orthotics on VO2 and selected frontal plane knee kinematics.

    abstract::The objective of this study was to investigate the effects of shoes and foot orthotics on running economy and selected frontal plane knee kinematics during the support phase of running. Twenty-one male runners who had been fitted with orthotics served as subjects. Subjects participated in three submaximal runs on a tr...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Burkett LN,Kohrt WM,Buchbinder R

    更新日期:1985-02-01 00:00:00

  • Physical Activity, Cardiorespiratory Fitness, and Incident Glaucoma.

    abstract:PURPOSE:This study aimed to examine the associations of physical activity and cardiorespiratory fitness (hereafter fitness) with incident glaucoma in a prospective observational study. METHODS:Physical activity was measured by self-reported leisure-time activities, and fitness was measured by maximal treadmill test. I...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001692

    authors: Meier NF,Lee DC,Sui X,Blair SN

    更新日期:2018-11-01 00:00:00

  • Impact and overuse injuries in runners.

    abstract::Forces that are repeatedly applied to the body could lead to positive remodeling of a structure if the forces fall below the tensile limit of the structure and if sufficient time is provided between force applications. On the other hand, an overuse injury could result if there is inadequate rest time between applied f...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1249/01.mss.0000126803.66636.dd

    authors: Hreljac A

    更新日期:2004-05-01 00:00:00

  • Sodium nitrate supplementation does not enhance performance of endurance athletes.

    abstract:PURPOSE:Supplementation with inorganic nitrate has been suggested to be an ergogenic aid for athletes as nitric oxide donor. The purpose of this study was to determine whether ingestion of inorganic sodium nitrate benefits well-trained athletes performing a 40-min exercise test in laboratory conditions. In addition, we...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0b013e3182687e5c

    authors: Bescós R,Ferrer-Roca V,Galilea PA,Roig A,Drobnic F,Sureda A,Martorell M,Cordova A,Tur JA,Pons A

    更新日期:2012-12-01 00:00:00

  • Alteration of trabecular bone under chronic beta2 agonists treatment.

    abstract:PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were d...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000177592.82507.95

    authors: Bonnet N,Brunet-Imbault B,Arlettaz A,Horcajada MN,Collomp K,Benhamou CL,Courteix D

    更新日期:2005-09-01 00:00:00

  • Comparable effects of diet and exercise on body composition and lipoproteins in older men.

    abstract::Changes in body composition, fat distribution and lipoprotein lipids in response to weight loss elicited by a 10-month program of hypocaloric diet (HD) therapy alone or combined with aerobic exercise training (AEX+HD) were examined in sedentary obese older males. Body composition was assessed by hydrodensitometry and ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章

    doi:

    authors: Dengel DR,Hagberg JM,Coon PJ,Drinkwater DT,Goldberg AP

    更新日期:1994-11-01 00:00:00

  • The validity and relevance of tests used for the assessment of sports surfaces.

    abstract::Inappropriate cushioning and/or tractional characteristics of sports surfaces are assumed to increase surface-related injuries in various sports activities. Various tests assessing cushioning and frictional properties are currently in use to evaluate sports surfaces with respect to their potential to reduce the number...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Nigg BM

    更新日期:1990-02-01 00:00:00

  • Effects of steady state exercise on the power spectrum of heart rate variability.

    abstract::The effects of steady state exercise on the power spectrum of heart rate variability were studied in 19 healthy subjects. Continuous ECG signals were recorded during 1) 15 min of rest in the supine state, 2) 10 min of standing, 3) 10 min of steady state exercise at 50% of maximum predicted power output on a cycle ergo...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Kamath MV,Fallen EL,McKelvie R

    更新日期:1991-04-01 00:00:00

  • Overuse injuries in the elite rock climber.

    abstract:UNLABELLED:Closed rupture of the flexor tendon sheath has been known to occur in the elite rock climbing population. However, only one study has investigated the prevalence of this entity. PURPOSE:To examine an elite climbing group in this country for the prevalence of pulley rupture and report on other commonly occur...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200008000-00002

    authors: Rohrbough JT,Mudge MK,Schilling RC

    更新日期:2000-08-01 00:00:00

  • Upper-limb bone mineral density of female collegiate gymnasts versus controls.

    abstract:PURPOSE:We examined bilateral bone mineral density (BMD) in the arms of female college gymnasts to assess the relative contribution of high-impact loading forces versus daily activities on bone plasticity. METHODS:Twenty-five female collegiate gymnasts and 25 controls were studied. BMD of the lumbar spine, proximal fe...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005768-200211000-00021

    authors: Proctor KL,Adams WC,Shaffrath JD,Van Loan MD

    更新日期:2002-11-01 00:00:00

  • Maximal blood flow and power output of dog muscle in situ.

    abstract::The two goals of this study were: 1) to establish a stimulation pattern which would drive the gastrocnemius-plantaris muscle of the dog, in situ, to maximal work rate, W, and 2) to determine whether the surgical isolation of the circulation of this muscle, necessary to measure the muscle flow, Q, reduced the muscle's ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/00005768-198810001-00003

    authors: Stainsby WN,Andrew GM

    更新日期:1988-10-01 00:00:00

  • Effect of pressure intensity of compression short-tight on fatigue of thigh muscles.

    abstract:PURPOSE:Existing studies have failed to provide evidence of a positive effect on exercise performance by wearing compression short tights covering only both thighs. This could be due to an inadequate pressure intensity that otherwise has a significant effect if applied on the crucial point in the thigh. This study aime...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000000330

    authors: Miyamoto N,Kawakami Y

    更新日期:2014-11-01 00:00:00

  • Modeling maximum oxygen uptake of elite endurance athletes.

    abstract:PURPOSE:To compare the maximum oxygen uptake V0(2max) of elite endurance athletes and to explain why the body mass exponent, necessary to render V0(2max) independent of body mass, appears to be greater than 0.67. METHODS:Study 1: V0(2max) of 174 international sportsmen and women was assessed. Athletes were recruited f...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.MSS.0000053728.12929.5D

    authors: Nevill A,Brown D,Godfrey R,Johnson P,Romer L,Stewart AD,Winter EM

    更新日期:2003-03-01 00:00:00

  • Physical fitness and body composition after a 9-month deployment to Afghanistan.

    abstract:PURPOSE:To examine change in physical fitness and body composition after a military deployment to Afghanistan. METHODS:One hundred and ten infantry soldiers were measured before and after a 9-month deployment to Afghanistan for Operation Enduring Freedom. Measurements included treadmill peak oxygen uptake (peak VO2), ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318176b978

    authors: Sharp MA,Knapik JJ,Walker LA,Burrell L,Frykman PN,Darakjy SS,Lester ME,Marin RE

    更新日期:2008-09-01 00:00:00

  • Perceived exertion during prepregnancy physical activity and preeclampsia risk.

    abstract:PURPOSE:Studies have shown that absolute intensity of physical activity is associated with reduced risk of preeclampsia. This analysis was performed to examine whether relative intensity may also be related to preeclampsia risk. METHODS:Using data from a case-control study conducted from 1998 to 2002, the authors asse...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000175862.41620.41

    authors: Rudra CB,Williams MA,Lee IM,Miller RS,Sorensen TK

    更新日期:2005-11-01 00:00:00

  • Effects of sequential bouts of resistance exercise on androgen receptor expression.

    abstract:PURPOSE:Increased serum testosterone (TST) occurs in response to resistance exercise and is associated with increased muscle mass. However, the effects of elevated TST and sequential resistance exercise bouts on androgen receptor (AR) expression in humans are not well known. This study examined three sequential bouts o...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1249/01.mss.0000139795.83030.d1

    authors: Willoughby DS,Taylor L

    更新日期:2004-09-01 00:00:00

  • Immune status of physically active women during lactation.

    abstract:PURPOSE:The purpose of this study was to provide baseline data on immune status of exercising and sedentary exclusively lactating women. Dietary intake and body composition were also investigated to determine whether they related to immune function. METHODS:Healthy, exclusively breastfeeding women with a body mass ind...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000128245.39808.36

    authors: Lovelady CA,Fuller CJ,Geigerman CM,Hunter CP,Kinsella TC

    更新日期:2004-06-01 00:00:00

  • Physical fitness, lipids, and apolipoproteins in the Northern Ireland Health and Activity Survey.

    abstract::The objective of this study was to investigate the relationship between physical fitness, lipids, and apolipoproteins in a cross-sectional study using a two-stage probability sample of the population of Northern Ireland. The main outcome measures were physical fitness using VO2max estimated by extrapolation from subma...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-199709000-00011

    authors: MacAuley D,McCrum EE,Stott G,Evans AE,Duly E,Trinick TR,Sweeney K,Boreham CA

    更新日期:1997-09-01 00:00:00

  • Exercise training reduces ischemic myocardial dysfunction.

    abstract:PURPOSE:This study tested the hypothesis that exercise training improves myocardial blood flow and regional myocardial contractile function in a lateral border zone located adjacent to the ischemic zone during coronary artery occlusion. METHODS:Fourteen dogs were subjected to either 12 wk of dynamic exercise training ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200104000-00008

    authors: Brandt MA,Gwirtz PA

    更新日期:2001-04-01 00:00:00

  • Vigorous exercise and diabetic, hypertensive, and hypercholesterolemia medication use.

    abstract:PURPOSE:The prevalences of diabetes, hypertension, and high cholesterol all decrease with increased levels of physical activity and cardiorespiratory fitness. Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e318145b337

    authors: Williams PT,Franklin B

    更新日期:2007-11-01 00:00:00

  • An operational model to investigate contact sports injuries.

    abstract:PURPOSE:A cyclical operational model is proposed to examine the interrelationship of a number of factors that are involved in sports injury epidemiology. In sports injury research, investigations often attempt to identify a unique risk factor that distinguishes an injured player. However, a wide variety of factors can ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200112000-00004

    authors: Gissane C,White J,Kerr K,Jennings D

    更新日期:2001-12-01 00:00:00

  • Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology.

    abstract:PURPOSE:Physical exercise or hypoxic exposure influences hemorheology and acid-base homeostasis. Band 3 protein in erythrocytes modulates cells' rheological properties and anion transport ability. This study investigated how cycling aerobic interval training (AIT) and moderate continuous training (MCT) affect the rheol...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0000000000000730

    authors: Chou SL,Huang YC,Fu TC,Hsu CC,Wang JS

    更新日期:2016-01-01 00:00:00