Abstract：
PURPOSE:Hyperventilation increases the clearance of carbon monoxide (CO) from blood; thus, we hypothesized that CO elimination would be enhanced with exercise. Accordingly, this study examined the effect of exercise on the half-life of carboxyhemolobin elimination. METHODS:Six healthy subjects (three males and three females) with mean ± SD ages of 23 ± 4 yr were exposed to CO sufficient to raise blood carboxyhemolobin concentration to 10-14% on five separate days. The half-life for CO elimination was measured breathing room air at rest and during exercise at three intensities. RESULTS:Comparisons showed that the half-life decreased with exercise from that during rest in all subjects. The half-life was also measured during 100% oxygen breathing at the lowest exercise intensity of 63 ± 15 W and found to be the least of all measured (23 ± 4 min). CONCLUSIONS:1) Exercise increased isocapnic ventilation, thereby decreasing the half-life of CO elimination. 2) The half-life of CO elimination represents a hyperbolic function of ventilation [y = y0 + (a / x)], and so increasing ventilation by exercise reaches a point of diminishing returns. 3) Breathing 100% oxygen during mild exercise is as effective in eliminating CO as treatment with hyperbaric oxygen. 4) Moderate exercise under room air conditions is as effective in eliminating CO as breathing oxygen at rest. Thus, the combination of mild exercise, hyperventilation, and normobaric hyperoxia (100% oxygen inhalation) may be considered the "triple therapy" for CO elimination in some patients.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Zavorsky GS,Smoliga JM,Longo LD,Uhranowsky KA,Cadman CR,Duffin J,Fisher JAdoi
10.1249/MSS.0b013e3182602a00subject
Has Abstractpub_date
2012-11-01 00:00:00pages
2118-24issue
11eissn
0195-9131issn
1530-0315journal_volume
44pub_type
杂志文章,随机对照试验abstract：PURPOSE:To compare the maximum oxygen uptake V0(2max) of elite endurance athletes and to explain why the body mass exponent, necessary to render V0(2max) independent of body mass, appears to be greater than 0.67. METHODS:Study 1: V0(2max) of 174 international sportsmen and women was assessed. Athletes were recruited f...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000053728.12929.5D
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:Although many studies have attempted to examine the effect of hypohydration on strength, power, and high-intensity endurance, few have successfully isolated changes in total body water from other variables that alter performance (e.g., increased core temperature), and none have documented the influence of hypoh...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/mss.0b013e3180de5f22
更新日期：2007-10-01 00:00:00
abstract：:The purpose of this study was to determine the effects of different volumes of high-intensity resistance training on isometric torque and muscle thickness. Training was conducted three times per week using one set (low volume, EX-1, N = 18) or three sets (high volume, EX-3, N = 20) of dynamic variable resistance exerc...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199610000-00016
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:This study determined the effects of a single session of heavy-resistance exercise on myosin heavy-chain (MHC) mRNA expression, along with the expression of the transcription factors Myo-D, myogenin, and Id-1. METHODS:Four male subjects participated in a control group (CON) and seven in a resistance-exercise g...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200208000-00006
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Sensitization of mechanosensitive afferents, which contribute to the exercise pressor reflex, has been recognized as a characteristic of patients with heart failure (HF); however, the hemodynamic implications of this hypersensitivity are unclear. OBJECTIVES:The present study used passive leg movement (PLM) ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000782
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to examine the effect of regular CHO beverage ingestion and restricted fluid intake on various salivary parameters during prolonged cycle exercise. METHODS:In a randomized block design, 15 recreationally active men cycled for 2 h at 60% VO2max on three occasions, separated by 1 wk...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200012000-00013
更新日期：2000-12-01 00:00:00
abstract：INTRODUCTION:Competitive female athletes restrict energy intake and increase exercise energy expenditure frequently resulting in ovarian suppression. The purpose of this study was to determine the impact of ovarian suppression and energy deficit on swimming performance (400-m swim velocity). METHODS:Menstrual status w...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3182a32b72
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:This study investigated whether natural killer (NK) cells and CD8+ T cells expressing cutaneous lymphocyte antigen (CLA)-a homing molecule for endothelial cell leukocyte adhesion molecule 1, which enables transmigration to the skin-are selectively mobilized in response to acute exercise. METHODS:Nine healthy m...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000914
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:The present study examined the effect of extreme old age on the plasticity of the rat plantaris muscle in response to an increase in mechanical load. METHODS:Male Fischer 344 rats, aged 7 months (adult) and 25 months (old) underwent bilateral surgical ablation of the gastrocnemius muscle to functionally overlo...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200207000-00010
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:The present study was designed to develop and validate a prediction equation for peak oxygen consumption VO2peak) using a progressive treadmill test and to refine the current target HR exercise guidelines for pregnancy (PARmed-X for Pregnancy). METHODS:One hundred fifty-six women between 16 and 22 wk of gestat...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000228940.09411.9c
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:One approach to studying the effects of aging on physiological functional capacity (PFC) in humans is to analyze the peak physical performance of trained athletes with increasing age. The primary aim of the present study was to determine weightlifting and powerlifting performance with increasing age in both men...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000106283.34742.BE
更新日期：2004-01-01 00:00:00
abstract：:Ten eumenorrheic nonathletic women, aged 21-25, were studied on the 8th day following the LH peak in three consecutive cycles. Plasma level and metabolic clearance rate (MCR) of estradiol (E2) and progesterone (P) were measured before and during a 2-h continuous treadmill test at a speed corresponding to 70% of their ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：INTRODUCTION:It is well established that hemodynamic dysfunction, resulting in diminished upper-extremity work capacity, occurs in persons with spinal cord injury (SCI) as compared with those who are nondisabled (ND). Although it has been shown that persons with paraplegia display higher values of heart rate (HR) with ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200209000-00001
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:The extent to which the diaphragm is targeted during a bout of inspiratory muscle training (IMT) is unknown. The purpose of this study was to characterize the relative activation patterns of the diaphragm and extradiaphragmatic inspiratory muscles during a bout of IMT and to determine whether diaphragmatic recr...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000881
更新日期：2016-06-01 00:00:00
abstract：:To determine the effect of large and sudden increases in training volume on performance characteristics and the feasibility of using overtraining syndrome symptoms to monitor performance changes, 15 elite judo athletes were examined through 10 wk of training. Athletes performed their regular regimens of resistance (3 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199012000-00014
更新日期：1990-12-01 00:00:00
abstract：PURPOSE:To study the effect of genetic factors, birth weight, early childhood growth, sport, hours of training, and pubertal status on the stature and body mass index (BMI) of children aged 9-13 participating in sports at a competitive level. METHODS:A total of 184 children (96 girls, 88 boys), competing in swimming, ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200010000-00006
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:High school cross-country runners have a high incidence of injury, particularly at the shin and knee. An increased step rate during running has been shown to reduce impact forces and loading of the lower extremity joints. The purpose of this prospective study was to examine step rate as a risk factor for injury...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000890
更新日期：2016-07-01 00:00:00
abstract：:The purpose was to study the effects of skipping rate on energy expenditure and sex differences in response to rope skipping. Responses of 19 males and 11 females were measured while skipping for 5 min at 125, 135 and 145 skips . min-1. Expired air was routed through a hollow handle to collection bags to provide unint...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：PURPOSE:The objective of this study was to quantify age-related changes in accelerometer-derived day-level physical activity and sedentary behavior pattern metrics (i.e., number, length, and temporal dispersion of bouts and breaks) across 3 yr of middle childhood. Differences by child sex and weekend versus weekday wer...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002247
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To examine serum creatine kinase (CK) activity after resistance exercise bouts with different rest intervals between sets and exercises in high responding (HR) and normal responding (NR) subjects. METHODS:During each resistance exercise bout, three sets with 10-repetition maximum (10RM) loads were completed fo...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181ca7e16
更新日期：2010-07-01 00:00:00
abstract：INTRODUCTION:This study examined the influence of a supplement matrix on the excretion pattern of nandrolone metabolites in response to ingestion of a trace amount of 19-norandrostenedione. METHODS:Ten male and nine female volunteers (mean ± SD: age = 26 ± 3 yr, height = 1.71 ± 0.09 m, body mass = 70.9 ± 13.2 kg) were...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e3181bf94d6
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Compare the influence of the chemoreflex on heart rate (HR) and blood pressure (BP) responses between children and adults. METHODS:Seventy children (35 boys and 35 girls) and 70 adults (35 men and 35 women) performed 30% maximal voluntary contraction static handgrip exercise (SHG) for 3 min, followed by 4 min ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/01.mss.0000155400.14813.df
更新日期：2005-03-01 00:00:00
abstract：:Sex is a potent modifier of the cardiovascular system because males and females differ in several aspects of the heart's biology and physiology. Epidemiologically, premenopausal women possess a distinct advantage over men in the occurrence of cardiovascular heart disease; however, this advantage shifts to men once a n...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：10.1249/MSS.0b013e3181621311
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:This pilot work was conducted to evaluate the effects of neuromuscular electrical stimulation resistance training (RT) of the paralyzed knee extensor muscle groups on skeletal muscle and intramuscular fat (IMF) cross-sectional areas, trunk visceral adipose tissue (VAT), carbohydrate, and lipid profiles in men w...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e31822672aa
更新日期：2012-01-01 00:00:00
abstract：:The present study was designed to assess the effects of acute exercise and short-term intensive training on catechol-O-methyltransferase (COMT) activity. COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2- (2-MeOE) and 4-methoxyestrogens (4-MeOE). Bl...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-199712000-00006
更新日期：1997-12-01 00:00:00
abstract：:The uptake of zinc (Zn) into the plasma after the ingestion of 25 mg of Zn from multivitamin-mineral supplement was studied in 10 men during running (R) and control (C) conditions; the R was for 2 h at 60-65% of their maximal oxygen uptake. Subjects took the supplement with 200 ml of deionized water before the R or C ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：PURPOSE:To determine the effect of dietary antioxidant restriction on oxidative stress, antioxidant defenses, and exercise performance in athletes. Oxidative stress has been shown to increase during exercise. To alleviate oxidative stress, a high intake of antioxidant rich foods or supplements may be required in traine...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/01.mss.0000150016.46508.a1
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:Orienteering athletes must adapt to running on various surfaces, with biomechanics likely contributing to performance. Here, our aims were to identify the effect of athletic status and of surface on the running biomechanics of orienteers. METHODS:Seven elite and seven amateur male orienteers ran 20 m on road, ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000413
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:This study was conducted to determine if fifth-grade students who walked or bicycled to school on a regular basis were more physically active than those that did not. METHODS:The sample consists of 219 fifth-grade students (10.3 +/- 0.6 yr, 44% male, 58% minority) from eight randomly selected urban and suburba...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000179102.17183.6b
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To assess physical activity, and its associations with health, clinical, and biochemical factors, in patients with stages 2-4 of chronic kidney disease (CKD). METHODS:Cross-sectional data were collected from 120 patients with CKD enrolled in the Lipid lowering and Onset of Renal Disease (LORD) trial. Patients ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181940aef
更新日期：2009-05-01 00:00:00
