Abstract:
BACKGROUND:Both obesity and smoking are common in schizophrenia patients taking clozapine, causing cardiovascular disease and premature deaths. METHODS:Two hundred and thirty-seven patients with schizophrenia or related psychoses treated with clozapine completed the Liverpool University Neuroleptic Assessment Scale (LUNSERS) and a questionnaire including current height, weight, changes therein and smoking status. AIMS:The aim of this study was to analyze weight and weight change in smoking and non-smoking patients taking clozapine. A possible interaction between obesity and smoking was explored. RESULTS:No association was found between weight change and smoking status during clozapine treatment. There was no significant difference in body mass index (BMI) between non-smokers and smokers. In the analysis of covariance (ANCOVA) with BMI as the dependent variable, the best fitting model comprised age, sex, intensity of sedation, and reported amount of smoking as explanatory variables (ηp(2)= 0.116; P = 0.029; power = 0.750). None of the explanatory proportions of any single factor was significant. CONCLUSIONS:Estimated according to reported weight gain and BMI, no difference was found between smoking and non-smoking clozapine-treated patients. Number of cigarettes smoked explained BMI if age and sex were taken into account. This result is in line with the findings of some general population studies, where heavy smoking has been associated with a greater risk of obesity.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Seppälä N,Leinonen E,Viikki M,Kampman Odoi
10.3109/08039488.2014.907340subject
Has Abstractpub_date
2014-11-01 00:00:00pages
620-5issue
8eissn
0803-9488issn
1502-4725journal_volume
68pub_type
杂志文章abstract:BACKGROUND:The Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL) is a semi-structured interview based on the Diagnostic and Statistical Manual of Mental Disorders (DSM), and assesses past and present symptoms in children aged 6-18 years old. It has been translated into more tha...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1733660
更新日期:2020-08-01 00:00:00
abstract:AIM:Toxoplasma gondii may play a role in the development of psychiatric diseases by affecting the brain. The purpose of this study was to examine the relation between serum toxoplasma IgG positivity and obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) in children and adolescents. METHOD:Sixty...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2017.1385850
更新日期:2018-01-01 00:00:00
abstract::The aim of the present study was to investigate the use and attitudes toward standardized assessment tools among clinicians in a public mental health service in Norway. A total of 606 clinicians provided feedback on their use and attitudes regarding psychometric qualities of such tools, their practicality, and their b...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1642383
更新日期:2019-10-01 00:00:00
abstract::Objective: To identify personality disorders comorbid with borderline personality disorder (BPD) that may confer greater risk for the presence of severe dissociative experiences. Method: Three hundred and one outpatients with a primary diagnosis of BPD were evaluated using the Structured Clinical Interview for DSM-IV ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1658127
更新日期:2019-11-01 00:00:00
abstract::Purpose: Identifying distinct dimensions of negative symptoms in First Episode Schizophrenia (FES) might result in a better understanding and treatment of this invalidating symptomatology. Aim of this study was to examine negative symptom structure in FES patients using the Positive and Negative Syndrome Scale (PANSS)...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1695286
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder have neurocognitive impairments, which are associated with poor functional outcomes. AIMS:This study evaluated the neurocognitive effects of aripiprazole in adolescents and young adults with bipolar disorder. METHODS:This was a 24-week, observational, prospective study perfor...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2011.643484
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Although the effect of obsessive-compulsive disorder (OCD) on sleep is not well-known, recent studies suggest an association between OCD and sleep quality. AIMS:We aimed to assess sleep quality in children and adolescents with OCD and to seek its association with OCD symptoms and OCD severity. METHODS:All ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1785005
更新日期:2021-01-01 00:00:00
abstract::Background: There is a lack of clinical studies that focus on different psychiatric disorders after trauma and the relationship with migration status.Purpose: To examine differences in psychiatric morbidity in traumatized patients referred to psychiatric treatment in Southern Oslo.Materials and methods: Hundred and te...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2020.1714724
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Neuropsychiatric symptoms (NPS) in cognitive disorders impair quality of life, increase caregiver stress, and may lead to earlier institutionalization and death. The objective of this study was to investigate the use of antipsychotics among persons with cognitive impairment in home care and residential care,...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2016.1191537
更新日期:2016-11-01 00:00:00
abstract:INTRODUCTION:The aim of the present study was to obtain point prevalence estimates of the metabolic syndrome according to the NCEP III criteria in a sample of patients with schizophrenia spectrum disorders treated with atypical antipsychotic drugs in Denmark and Sweden, and to assess the psychiatrists' choice of recomm...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2010.486443
更新日期:2011-02-01 00:00:00
abstract::The purpose of this study was to assess the self-concept using the Offer Self-Image Questionnaire (OSIQ) in groups of Finnish adolescent girls with anorexia nervosa and bulimia nervosa, and a normal control group without an eating disorder. A total of 135 adolescent girls aged 16-21 (10 with anorexia nervosa, 10 with ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480260389370
更新日期:2002-01-01 00:00:00
abstract::Background Immunological mechanisms may be responsible for the development and maintenance of schizophrenia symptoms. Aim The aim of this study is to measure tumour necrosis factor-alpha (TNF-α), soluble tumour necrosis factor-alpha receptor I (sTNF-αRI), and soluble tumour necrosis factor-alpha receptor II (sTNF-αRII...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2015.1122079
更新日期:2016-07-01 00:00:00
abstract::The purpose of the article: Brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) are involved in the processes of neurogenesis, synaptic plasticity, learning and memory. Growing number of studies shows a relationship between BDNF or MMP-9 and schizophrenia. Also, BDNF and MMP-9 levels may be...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1658126
更新日期:2019-11-01 00:00:00
abstract::Background and aim: Recent evidence suggests that growth factors might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The aim of this study was to determine whether serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), neurotrophin-3...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1625437
更新日期:2019-01-01 00:00:00
abstract::The purpose of the present study was to investigate the effectiveness of cognitive-behavioural group treatment of panic disorder and agoraphobia in a clinical setting. Fifty-three patients were offered treatment and assessed before, after and at follow-up 1 1/2-2 years after treatment. The study included an informal w...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480510027670
更新日期:2005-01-01 00:00:00
abstract::The neurodevelopmental hypothesis of schizophrenia has gained increasing acceptance. This hypothesis assumes a disruption in the normal development of the brain, secondary to genetic factors, environmental factors, or, most likely, a combination of both. After a brief review of the various aetiologic models since the ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.1080/080394801317080792
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Declared suicidal intent and physical danger are both considered important components in defining suicidal behaviors (SB). AIMS:1) To investigate characteristics of serious suicidal behaviors (SSB), defined by either suicidal intent or lethality; 2) To determine any difference in terms of socio-demographic,...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,多中心研究
doi:10.3109/08039488.2013.767934
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Long acting injectable antipsychotics (LAI-APs) are considered a major advance in psychiatric treatment concerning treatment adherence and outcomes. Yet, both, doctors and patients remain sceptical. AIM:To explain the rationale for using LAI-APs, review their effectiveness and explore barriers to use. METH...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.1080/08039488.2018.1525638
更新日期:2018-09-01 00:00:00
abstract::Purpose: The aim of this study is to compare differences in metacognitive beliefs between patients with bipolar disorder type I (BPDI) with previous suicide attempts (BPDI+), those without suicide attempts (BPDI-), and a control group. It also discusses the relationship between metacognitive beliefs and suicidal behav...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1649722
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Previous meta-analyses of paediatric obsessive-compulsive disorder (OCD) have shown much higher effect size for standard individual cognitive behaviour therapy (SI-CBT) compared with control conditions than for serotonin reuptake inhibitors (SRIs) compared with placebo. Other factors, such as systematic diff...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.3109/08039488.2014.941395
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Central serous chorioretinopathy (CSC) has been associated with several psychological factors. But previous psychological data are limited and mainly restricted to male patients and small sample size. In this study we investigated psychosomatic complaints, personality factors, life events, and stress coping ...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2015.1041156
更新日期:2016-01-01 00:00:00
abstract::Background: Resolvin D1 (RvD1) is a soluble mediator, which is the metabolite of docosahexaenoic acid (DHA), an omega-3 fatty acid. It is thought that RvD1 may contribute to the etiology of bipolar disorder (BD) because of its anti-inflammatory and antidepressant effect. In this study, it was aimed to compare the seru...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1673480
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:A possible relationship has been suggested between social anxiety and dissociation. Traumatic experiences, especially childhood abuse, play an important role in the aetiology of dissociation. AIM:This study assesses childhood trauma history, dissociative symptoms, and dissociative disorder comorbidity in pa...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2016.1218050
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Few studies have focused on conduct problems and co-occurring problems among the youngest children in schools, such as social, internalizing and attention problems. In particular, there is a lack of studies that differentiate between boys and girls in terms of such problems. AIM:The aim of the current study...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,评审
doi:10.3109/08039488.2012.731432
更新日期:2013-08-01 00:00:00
abstract::Aims: This study describes changes in alcohol habits in age and gender strata among the Swedish general population during the 21-year period following the Swedish EU membership in 1995. Methods: The Alcohol Use Disorders Identification Test (AUDIT) was distributed as a postal questionnaire to randomly selected cross-s...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1660912
更新日期:2019-11-01 00:00:00
abstract:AIMS:Knowledge of sleep problems and their relationships among adolescent psychiatric patients is limited. This study investigated whether adolescents in specialty mental health care differ in rate and correlates of sleep problems from adolescents in a community sample; 2465 adolescents from a community sample were com...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903282392
更新日期:2010-05-04 00:00:00
abstract::Background: Body dysmorphic disorder (BDD) is preoccupation with perceived body defects leading to distress and impairment in social functioning. Most of adolescent BDD literature has been done on patients within the outpatient setting with prior versions of DSM with dearth of information about BDD and comorbid psychi...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2019.1612943
更新日期:2019-01-01 00:00:00
abstract::The association between alcohol dependence and suicidal behaviour is well established and patients with suicidal behaviour in treatment for alcohol dependence present a considerable challenge for clinical services. The aim of this study is to identify risk factors for suicide attempts and to evaluate the outcome of tr...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039480802559965
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:In Norway, GPs may decide to refer patients to involuntary psychiatric treatment. Internationally, there has been a discussion regarding criteria for involuntary admission. In Norway and in other countries where the treatment criterion is still used, some have suggested its removal. AIMS:To examine which le...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039488.2015.1046915
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The exact mechanisms for antipsychotic-induced extrapyramidal side-effects have remained obscure despite intensive research. Previous studies have highlighted a central role for nigral dopamine D(2) receptors in the control of motor functions. AIMS:The aim of the present study was to examine relationships b...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.3109/08039480903484076
更新日期:2010-08-01 00:00:00