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Reducing the stigma of long acting injectable antipsychotics - current concepts and future developments.

Abstract：

BACKGROUND:Long acting injectable antipsychotics (LAI-APs) are considered a major advance in psychiatric treatment concerning treatment adherence and outcomes. Yet, both, doctors and patients remain sceptical. AIM:To explain the rationale for using LAI-APs, review their effectiveness and explore barriers to use. METHOD:Clinical overview of LAI-APs from the patient and doctor's perspective. RESULTS:LAI-APs were developed to increase adherence to treatment, thereby improving treatment outcomes. LAI-APs may reduce the risk of relapse and hospitalisation. Yet, the evidence from the few meta-analyses available remains weak. Both patients and doctors may associate LAI-APs with stigma and coercion. Current means of improving adherence include more focus on the therapeutic relationship, better information, adverse effects minimisation and half-life extension of LAI-APs. Future means of improving adherence include novel administration techniques that abolish the need for injection. CONCLUSIONS:For both, clinicians and drug developers, drug adherence remains a major target for improving treatment outcomes.

journal_name

Nord J Psychiatry

journal_title

Nordic journal of psychiatry

authors

Taylor DM,Velaga S,Werneke U

doi

10.1080/08039488.2018.1525638

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

S36-S39

issue

sup1

eissn

0803-9488

issn

1502-4725

journal_volume

72

pub_type

杂志文章,评审

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