Abstract:
:Background and aim: Recent evidence suggests that growth factors might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The aim of this study was to determine whether serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), nerve growth factor (NGF), fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) were altered in children with ADHD. Methods: Serum levels of BDNF, GDNF, NT-3, NGF, VEGF and FGF-2 were analyzed in 49 treatment- naive children with ADHD and age, gender matched 36 healthy controls using enzyme-linked immunosorbent assay. ADHD symptoms were scored by Du Paul ADHD Rating Scale and Strengths and Difficulties Questionnaire. Results: We found that serum VEGF levels were significantly lower (p < 0.001) and GDNF levels were significantly higher in ADHD group compared to control group (p = 0.003). However, we found no correlations between ADHD symptoms and serum VEGF or GDNF levels. Furthermore, we observed no significant alterations in serum BDNF, NT-3, NGF, FGF-2 levels in children with ADHD. Conclusion: To our knowledge, the present study is the first to examine serum VEGF and FGF-2 levels in children with ADHD. Our results indicate that VEGF and GDNF might be involved in the etiology of ADHD. Further studies are required to determine the role of growth factors in the etiology and consequently in the treatment of ADHD.
journal_name
Nord J Psychiatryjournal_title
Nordic journal of psychiatryauthors
Yurteri N,Şahin İE,Tufan AEdoi
10.1080/08039488.2019.1625437subject
Has Abstractpub_date
2019-01-01 00:00:00pages
302-307issue
4-5eissn
0803-9488issn
1502-4725journal_volume
73pub_type
杂志文章abstract:BACKGROUND:Extreme self-harming behavior is a major challenge for patients and health services. Nevertheless, this patient population is poorly described in research literature. AIMS:The aim of this study was to assess the volume of patients with extensive psychiatric hospitalization due to extreme self-harming behavi...
journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
doi:10.1080/08039488.2018.1511751
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The psychopathic traits measured with the Hare Psychopathy Checklist-Revised (PCL-R) in a representative national prisoner sample have not been studied in Finland before. It has been unclear whether there could occur some national differences or whether the PCL-R can be used for assessing psychopathic traits...
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journal_title:Nordic journal of psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.3109/08039488.2014.941395
更新日期:2015-02-01 00:00:00
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journal_title:Nordic journal of psychiatry
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pub_type: 杂志文章,评审
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doi:10.3109/08039488.2015.1112832
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doi:10.3109/08039488.2012.754051
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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doi:10.1080/08039480600601282
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1080/08039488.2018.1513068
更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/08039480310000248
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/08039488.2010.522729
更新日期:2011-06-01 00:00:00
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journal_title:Nordic journal of psychiatry
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-01-01 00:00:00