Abstract:
:Percutaneous coronary interventions (PCI), including balloon angioplasty and implantation of both bare metal and drug eluting coronary stents, are associated with risk of restenosis and in-stent thrombosis. A better understanding of signals that regulate cellular proliferation, neointimal formation and vessel wall thickening following PCI may contribute to identify novel preventive and therapeutic strategies aimed to reduce the atherosclerosis progression and the consequent vascular sequelae. Among the possible mechanisms, an increased level of reactive oxygen species (ROS) is associated with endothelial dysfunction and vascular smooth muscle cells (VSMCs) proliferation and migration involved in the post-procedural remodeling process. This review article provides an overview of the current knowledge on the contribution of increased oxidative stress to the post-procedural pathological vascular changes. We discuss the role of nicotinamide adenine dinucleotide phosphate oxidase, nitric oxide synthase, and of proteins regulating the mitochondrial function and dynamics. We will also highlight new knowledge on the atypical Fat1 cadherin that appears to play a key role in VSMCs proliferation. In fact, its induction after vascular injury serves as a physiological regulator of VSMCs growth. Specific molecular mechanisms, including Pin1- and H2S-mediated pathways, have been identified in the vascular complications of type 2 diabetic patients. The identification of novel key players may expand our perspectives and promote the development of new tools for future preventive and therapeutic strategies in order to reduce the adverse vascular remodeling following PCI. The latter represents one of the major goals in the development of innovative technologies with relevance for clinical practice.
journal_name
Int J Cardioljournal_title
International journal of cardiologyauthors
Gallo G,Pierelli G,Forte M,Coluccia R,Volpe M,Rubattu Sdoi
10.1016/j.ijcard.2018.05.046subject
Has Abstractpub_date
2018-10-01 00:00:00pages
27-33eissn
0167-5273issn
1874-1754pii
S0167-5273(18)31719-4journal_volume
268pub_type
杂志文章,评审abstract:BACKGROUND:Neuregulin1 (Nrg1) and its receptors ErbB are crucial for heart development and for adult heart structural maintenance and function and Nrg1 has been proposed for heart failure treatment. Infarct size is the major determinant of heart failure and the mechanism of action and the role of each ErbB receptor rem...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2017.01.122
更新日期:2017-04-15 00:00:00
abstract:BACKGROUND:Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2016.12.021
更新日期:2017-03-15 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid intimal medial thickness (IMT) is a measure of subclinical atherosclerosis and is predictive of future cardiovascular events. The purpose of this study was to determine the significance and magnitude of association between IMT and atherosclerotic calcification of the carotid arteries. ME...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2004.12.039
更新日期:2005-08-03 00:00:00
abstract:OBJECTIVE:Oxidative stress seems to play a role in impairing flow-mediated dilation (FMD) in patients with peripheral artery disease (PAD) but the underlying mechanism is still undefined. We evaluated whether NOX2, the catalytic core of NADPH oxidase, the most important producer of reactive oxidant species (ROS), is im...
journal_title:International journal of cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijcard.2012.01.069
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:As drug-eluting stent (DES) has almost overcome the disadvantage of frequent restenosis, off-pump coronary artery bypass grafting (OPCAB) has been introduced to avoid complications of cardiopulmonary bypass. However, which approach may promise better outcomes for patients with coronary artery disease remains...
journal_title:International journal of cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijcard.2014.04.182
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Takotsubo cardiomyopathy (TTC) is a novel heart disease, mimicking acute myocardial infarction. The term "transient left ventricular dysfunction syndrome" (TLVDS) seems to be more appropriate since variant forms of TTC sparing apical segments (mid-ventricular ballooning syndrome (MVBS) and inverted TTC) have...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.04.025
更新日期:2010-10-08 00:00:00
abstract::Tako-Tsubo cardiomyopathy (TTC) which is usually precipitated by profound emotional and physical stress has been widely reported in the past. In this case we report a young female patient who developed sudden dyspnea and palpitation after an profound stress (fierce argument).The patient had characteristic feature of p...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.04.047
更新日期:2009-07-10 00:00:00
abstract::A 19-year-old man had a documented ventricular fibrillation during a football match. He was a top-level athlete, and after successful resuscitation, he was extensively studied. Electrolytic disturbances, long QT syndrome and nervous mechanisms were all ruled out. Right and left ventriculography, coronary angiograms, e...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90053-3
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Non-cardiac complications, such as hepato-renal and metabolic problems, are emerging late after the Fontan operation due to its unique hemodynamics. Consequently, associations between clinical variables and postoperative outcome may change during the prolonged postoperative course. METHODS AND RESULTS:To de...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.03.001
更新日期:2014-05-01 00:00:00
abstract::The incidence ratio of thyrotoxicosis among 14 patients with thyroid diseases associated with hypertrophic cardiomyopathy was compared with that in 7686 patients with thyroid diseases, to find the possible correlation between thyrotoxicosis and hypertrophic cardiomyopathy. Thyrotoxicosis did not predominate over other...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(86)90103-8
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Psychosocial stress could be an underlying factor for emerging risk of cardiovascular diseases (CVD) in Africans. We assessed the association between psychosocial stress and estimated CVD risk among non-migrant Ghanaians and migrant Ghanaians living in Europe. METHODS:Data from the Research on Obesity and D...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2018.12.056
更新日期:2019-07-01 00:00:00
abstract::The journey of atherosclerosis begins with endothelial dysfunction and culminates into its most fearful destination producing ischemia, myocardial infarction and death. The excess cardiovascular disease morbidity and mortality in African-Americans is one of the major public health problems. In this review, we discuss ...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2008.10.007
更新日期:2009-02-20 00:00:00
abstract::Lipomatous metaplasia of myocardium after myocardial infarction (MI) is less reported, and the exact prevalence and clinical implications of this phenomenon are unclear. A case of lipomatous metaplasia after MI evaluated with cardiovascular magnetic resonance (CMR) and computed tomography (CT) is presented. The presen...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2006.07.094
更新日期:2007-01-31 00:00:00
abstract::A rare combination of primary cardiac amyloidosis and bone amyloidosis is described in a 39-year-old female. The presenting features were restrictive heart disease and a destructive bone lesion. The diagnosis was confirmed with the help of endomyocardial and bone biopsy. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(89)90080-6
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the Friedewald Formula with direct homogeneous low density lipoprotein cholesterol (LDL-C) assay for the detection of LDL-C levels. METHODS:Fasting serum samples were obtained for lipid analysis from 1001 patients. Total cholesterol (TC) and triglyceride (TG) levels were...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2008.11.141
更新日期:2010-06-25 00:00:00
abstract:BACKGROUND:Stroke is the second cause of death worldwide and over than 80% of deaths occurs in developing countries. However, its characteristics in the Democratic Republic of Congo (DRC) are poorly defined. This study aimed to describe the key features of stroke in a hospital population of Kinshasa in DRC and to asses...
journal_title:International journal of cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijcard.2017.04.063
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Previous research demonstrates that participation in light-intensity physical activity (LIPA) and moderate-to-vigorous physical activity (MVPA) are favorably associated with health-related quality of life (HRQOL). Emerging work demonstrates that sedentary behavior (SB) is detrimentally associated with variou...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2016.06.256
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ven...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.09.024
更新日期:2019-01-01 00:00:00
abstract::Maintenance of normal potassium (K(+)) homeostasis has become an increasingly important limiting factor in the therapy of heart failure (HF). With the application of loop diuretics and digoxin, hypokalemia has become a frequent and feared side effect of treatment. Low serum K(+) in HF may be also a marker of increased...
journal_title:International journal of cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.ijcard.2011.06.121
更新日期:2012-06-28 00:00:00
abstract:BACKGROUND:Vascular wall remodeling is a major factor contributing to restenosis after angioplasty that involves migration and proliferation of vascular smooth muscle cells. The release of matrix-degrading metalloproteinases, including metalloproteinase-2 and metalloproteinase-9, facilitates remodeling. Experimental da...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(03)00092-5
更新日期:2003-12-01 00:00:00
abstract:INTRODUCTION:We aimed to study the prevalence and types of sleep apnea (SA) as well as their clinical characteristics in atrial fibrillation (AF) ablation candidates in Japan. METHODS:Before catheter ablation, 197 consecutive AF patients (age: 60 ± 9 years, body mass index; 25.0 ± 3.0) were evaluated with portable pol...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.01.103
更新日期:2018-06-01 00:00:00
abstract::We studied long-term variability of QT-dispersion in three patients with hypertrophic cardiomyopathy (Maron III) and ventricular fibrillation. Late potentials were absent on signal-averaged electrocardiogram. ST-segment depression was recorded in all three patients at Holter monitoring, and in two during exercise stre...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(94)90267-4
更新日期:1994-06-15 00:00:00
abstract:BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2018.02.072
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:To date, patients displaying stable angina with or without a previous acute coronary event have been grouped together and are offered nowadays, similar clinical approach. However, from clinical experience, increasing doubt exists whether they behave clinically in the same way. In the current study, we invest...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/s0167-5273(03)00028-7
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Studies of the association between hypertensive response (HR) in the exercise treadmill testing (ETT) and end organ damage are mostly cross-sectional and have not used ABPM. We investigated the association of different definitions of HR with incidence of hypertension by ABPM and development of cardiac struct...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2008.11.208
更新日期:2010-06-11 00:00:00
abstract::The Sassanid Empire in Persia (224-637 AD) ruled one of the most influential eras in world history. They with the Romans and later the Byzantines were two global powers in ancient times. Medicine was well organized in the official Sassanid system. Hospitals, medical centers, and universities were developed throughout ...
journal_title:International journal of cardiology
pub_type: 历史文章,杂志文章
doi:10.1016/j.ijcard.2014.01.035
更新日期:2014-03-15 00:00:00
abstract:OBJECTIVE:To investigate if oral health parameters were impaired in patients with myocardial infarction (MI) and if there was an association with serum antibody levels against the periodontal pathogens Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa). METHODS:A case-control study consisting...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2009.10.034
更新日期:2011-04-14 00:00:00
abstract::Paradoxical embolism across a patent foramen ovale (PFO) is a rare clinical entity and the thrombus is rarely caught passing through a PFO. A 65-year-old woman presented with dyspnea and pleuritic chest pain. Lower extremity venous Doppler ultrasound showed bilaterally extensive thrombosis at deep veins. Transthoracic...
journal_title:International journal of cardiology
pub_type: 信件
doi:10.1016/j.ijcard.2007.11.007
更新日期:2009-04-03 00:00:00
abstract::Two patients in whom a massive bolus of air was introduced into the arterial circuit and ascending aorta during valve replacement and in whom the recovery was complete are presented. The technical details of the management of this serious accident are described. ...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/0167-5273(85)90236-0
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Existing formulas for rate-corrected QT (QTc) commonly fail to properly adjust the upper normal limits which are more critical than the mean QTc for evaluation of prolonged QT. Age- and sex-related differences in QTc are also often overlooked. Our goal was to establish criteria for prolonged QTc using formul...
journal_title:International journal of cardiology
pub_type: 杂志文章
doi:10.1016/j.ijcard.2014.04.133
更新日期:2014-07-01 00:00:00