Abstract:
:A 16-year-old galactosemic patient, homozygous for the 5.5-kb gene deletion, suffered severe neurologic regression following streptococcal infection. Since the gene deletion includes the promoter of interleukin-11a receptor involved in neuronal apoptosis, we questioned whether this patient had no interleukin-11a receptor activity-resulting in neuronal toxicity during septicemia. We hypothesized that interleukin-11 levels would be elevated because of a loss of feedback induced by the absent interleukin-11Ra receptor complex. To assess this, we compared interleukin-11 levels in the proband and 2 of his siblings with the same genetic deletion, to age-matched controls. No differences were found in interleukin-11 levels between groups. Our study was not carried out during acute infective states, when the disrupted immunoregulation triggered by sepsis is relevant, and is thus limited. In conclusion, although interleukin-11 was not chronically elevated in individuals with galactosemia and 5.5-kb gene deletion, data do not rule out potential interleukin-11 dysfunction during acute infection.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Winter GN,Ben-Pazi Hdoi
10.1177/0883073814540520subject
Has Abstractpub_date
2015-06-01 00:00:00pages
922-6issue
7eissn
0883-0738issn
1708-8283pii
0883073814540520journal_volume
30pub_type
杂志文章abstract::Alexander disease is a leukodystrophy caused by dominant missense mutations in the gene encoding the glial fibrillary acidic protein. Individuals with this disorder often present with a typical neuroradiologic pattern including white matter abnormalities with brainstem involvement, selective contrast enhancement, and ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073816673263
更新日期:2017-02-01 00:00:00
abstract::Gelastic seizure is a rare symptom often associated with hypothalamic hamartoma. We present here a 4-year-old girl with gelastic epilepsy caused by hypothalamic hamartoma and report the magnetic resonance spectrometry and electroencephalographic (EEG) findings. At the age of 2 1/2 years, she developed brief, repetitiv...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700111
更新日期:2002-01-01 00:00:00
abstract::Hereditary sensory and autonomic neuropathies have different phenotypes. We report 2 cousins with differing clinical courses of a hereditary sensory and autonomic neuropathy. The progressive disease in case 1 is dominated by loss of sensation, autonomic crises, and pain. Case 2 shows loss of sensation, mental retardat...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811416664
更新日期:2012-02-01 00:00:00
abstract::The aim of this study was to investigate the alteration of the gait pattern in 25 children with Duchenne muscular dystrophy, using body-worn inertial sensors during a long walking distance. Normalized spatiotemporal gait parameters and their variability were extracted from the angular velocity of the shanks; the smoot...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811413581
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To quantify the number of personnel, time to induce and complete sedation using propofol for outpatient magnetic resonance imaging (MRI) of the brain, and the frequency of serious adverse events (SAEs) in children with autism spectrum disorder (ASD) compared with children without ASD. RESULTS:Baseline charac...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073817753908
更新日期:2018-04-01 00:00:00
abstract::Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine the prevalence of sleep problems in children with the common neurodevelopmental disorder neurofibromatosis type 1, a cross-sectional study was performed on 129...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813500849
更新日期:2013-11-01 00:00:00
abstract::Intravenous immunoglobulin has been reported to be an effective treatment for infantile spasms. Juvenile spasms are electrically and clinically similar to infantile spasms but occur in a later age group. We retrospectively reviewed the charts of five children (aged 4.5-11.5 years) at our institution. Their primary sei...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180061001
更新日期:2003-06-01 00:00:00
abstract::Young children with sickle cell disease are at risk of brain damage, including stroke. We tested the hypothesis that such patients are also at risk of cognitive impairment. We characterized the cognitive ability of kindergarten children to minimize the effect of disease-related school absence. The Memphis City Schools...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700204
更新日期:2002-02-01 00:00:00
abstract::Smith-Lemli-Opitz syndrome is a unique malformation syndrome characterized by a defect in cholesterol biosynthesis, which is very rare among populations in Middle and East Asia. The authors identified compound heterozygous mutations ([p.Arg352Trp] + [p.Lys376ArgfsX37]) in a Korean girl with clinical and laboratory fea...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807307099
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology. METHODS:In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diag...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820972232
更新日期:2020-11-18 00:00:00
abstract::We accumulated 440 cases of intracranial meningiomas in patients under 16 years of age, and another 27 personal. This review confirms the existence of specific clinical features of spontaneous and radiation-induced meningioma in children. In addition, we discuss various points that suggest a more aggressive behavior o...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738060210010801
更新日期:2006-01-01 00:00:00
abstract::Movement disorders, a common problem in children with neurologic impairment, are receiving increasing clinical attention. The differences in movement disorders between adults and children are striking; presentation is frequently insidious and may be characterized by mild hypotonia. The clinical manifestations of extra...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073803018001S0601
更新日期:2003-09-01 00:00:00
abstract::Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral pa...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738060210050201
更新日期:2006-05-01 00:00:00
abstract::Solitary tumefactive demyelination is rare in children, and the diagnosis is often conferred after brain biopsy. The authors report 3 children with solitary tumefactive demyelination and provide clinical and paraclinical clues to aid the clinician in reaching a diagnosis using a noninvasive approach. ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811401402
更新日期:2011-08-01 00:00:00
abstract::The influence of severity of closed head injury and age on attentional functioning was prospectively investigated in 36 children (age range, 7 to 16 years) 6 months after injury. Children were placed into mild, moderate, and severe injury groups using established neurologic criteria. Each child received the Wechsler I...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389300800410
更新日期:1993-10-01 00:00:00
abstract:AIM:We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center. METHOD:Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820916260
更新日期:2020-07-01 00:00:00
abstract::We report a 6-month-old boy with diffuse hypertonia and developmental delay who had unilateral separated-lip schizencephaly and contralateral polymicrogyria. The contralateral polymicrogyria was associated with an incomplete clefting in that hemisphere. An umbilical cord hamartoma is presumed to have caused hypoperfus...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180031401
更新日期:2003-03-01 00:00:00
abstract::The most devastating complications of tuberous sclerosis complex affect the central nervous system and include epilepsy, mental retardation, autism, and glial tumors. Mutations in one of two genes, TSC1 and TSC2, result in a similar disease phenotype by disrupting the normal interaction of their protein products, hama...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738040190091401
更新日期:2004-09-01 00:00:00
abstract::Despite being a treatable and preventable zoonosis, brucellosis is still endemic in certain areas of the world. Nervous system involvement is a rare but an important complication of brucellosis in childhood. Neurobrucellosis should be taken into consideration in the differential diagnosis of any kind of neurological s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811402205
更新日期:2011-10-01 00:00:00
abstract::Mutations in the STE20-related kinase adaptor α ( STRADA) gene have been reported to cause an autosomal recessive neurodevelopmental disorder characterized by infantile-onset epilepsy, developmental delay, and craniofacial dysmorphisms. To date, there have been 17 reported individuals diagnosed with STRADA mutations, ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818802724
更新日期:2018-12-01 00:00:00
abstract::Six cases of childhood multiple sclerosis (MS) are presented. All patients (three boys and three girls) were black and came from the Washington, DC, metropolitan area. Age at onset of the disease ranged from 8 to 17 years. Although motor deficits, optic neuritis, and ataxia were similar to those previously reported in...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389100600112
更新日期:1991-01-01 00:00:00
abstract::The objective of this study was to compare the efficacy of corticotropin (ACTH) versus vigabatrin in treating infantile spasms and to determine which medication has a more favorable long-term outcome in terms of cognitive function, evolution of epilepsy, and incidence of autism. Patients with infantile spasms were inc...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/08830738030180030801
更新日期:2003-03-01 00:00:00
abstract::Paroxysmal kinesigenic dyskinesia is a rare episodic movement disorder that can be isolated or associated with benign infantile seizures as part of choreoathetosis syndrome. Mutations in the PRRT2 gene have been recently identified as a cause of paroxysmal kinesigenic dyskinesia and infantile convulsion and choreoathe...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814556887
更新日期:2015-09-01 00:00:00
abstract::Acute cerebellitis is a rare condition often considered within the group of acute postinfectious cerebellar ataxia despite its distinctive clinical and imaging features. We retrieved clinical, laboratory, and follow-up data of 15 children diagnosed with acute cerebellitis in our department between 2011 and 2019. There...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820901407
更新日期:2020-05-01 00:00:00
abstract::In this study we investigated centrally mediated parasympathetic regulation of modulated cardiac vagal tone among children with severe cyanotic and pallid breath-holding spells by examining respiratory sinus arrhythmia. Respiratory sinus arrhythmia was evaluated in 41 children; 17 subjects with cyanotic breath-holding...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389801300905
更新日期:1998-09-01 00:00:00
abstract::We describe a case of pathologically confirmed Alexander's disease in which serial cranial ultrasound studies demonstrated unique findings of enlarging subependymal cysts with evolving periventricular hyperechogenicity. Computed tomographic scan of the head showed low attenuation of the periventricular white matter an...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500320
更新日期:1990-07-01 00:00:00
abstract::To evaluate the consistency of the Hammersmith Infant Neurological Examination scores of very-low-birth-weight infants at 6 and 12 months of age and its correlation to cranial ultrasonography findings, we designed a prospective study between January 2005 and January 2008, in the tertiary Neonatal Unit of Aristotle Uni...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813479171
更新日期:2014-11-01 00:00:00
abstract::The purpose of this study was to determine which clinical characteristics correlated with abnormal computed tomographic (CT) scans in epileptic children. Thirty variables were examined. Of these, four variables (presence of inherited or congenital disease, focal motor findings, developmental delay, and early onset of ...
journal_title:Journal of child neurology
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更新日期:1986-04-01 00:00:00
abstract::Childhood disintegrative disorder, a rare, relentlessly progressive neurologic disorder, first described by Heller in 1908, remains a condition of great interest. It has long been debated whether it is a discrete disorder or simply a late-onset variant of childhood autism. We have studied 6 cases of childhood disinteg...
journal_title:Journal of child neurology
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更新日期:2013-12-01 00:00:00
abstract::Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813520500
更新日期:2015-01-01 00:00:00