Abstract：
:Intravenous immunoglobulin has been reported to be an effective treatment for infantile spasms. Juvenile spasms are electrically and clinically similar to infantile spasms but occur in a later age group. We retrospectively reviewed the charts of five children (aged 4.5-11.5 years) at our institution. Their primary seizure type was juvenile spasms and they were treated with a single inpatient course of intravenous immunoglobulin (400 mg/kg/day intravenously for 5 consecutive days) on an adjunctive basis. Seizure frequency was determined from parental reports. By 3 months after treatment, improvement (a 50-92% reduction in seizure frequency) was noted in four patients; sustained benefit was seen in three patients for up to 12 months. One patient showed no response at 3 and 6 months and had an increase in seizure frequency at 1 year. We conclude that single-course intravenous immunoglobulin can be effective as adjunctive therapy for juvenile spasms and that benefit can persist for many months. However, larger controlled, prospective clinical trials are needed to validate this unconventional treatment modality for specific seizure types such as juvenile spasms.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Bingel U,Pinter JD,Sotero de Menezes M,Rho JMdoi
10.1177/08830738030180061001subject
Has Abstractpub_date
2003-06-01 00:00:00pages
379-82issue
6eissn
0883-0738issn
1708-8283journal_volume
18pub_type
杂志文章abstract：:Myoclonus epilepsy with ragged red fibers (MERRF) is one of the major mitochondrial encephalomyopathies. Its main clinical features are myoclonus epilepsy, ataxia, and myopathy with ragged red fibers. Whereas there is a close correlation between MERRF syndrome and the A8344G mutation of mitochondrial DNA, the reverse ...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/08830738060210010901
更新日期：2006-01-01 00:00:00
abstract：:Neurocysticercosis is a common parasitic infection of the central nervous system. Intraparenchymal giant cysticercosis has been described in literature, but this is a rare report of a thalamic giant cysticercosis in a young child where the diagnosis could be made on follow-up. A 1½-year-old male child presented with s...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073813513332
更新日期：2014-11-01 00:00:00
abstract：:Levetiracetam, one of the newer-generation antiepilepsy drugs, is not currently approved for use in children. Given its favorable efficacy, pharmacokinetic, and, particularly, safety profile in adults, we felt that it may be a useful antiepilepsy drug for children with refractory epilepsy. We treated 39 patients (mean...
journal_title：Journal of child neurology
pub_type： 临床试验,杂志文章
doi：10.1177/088307380201700603
更新日期：2002-06-01 00:00:00
abstract：:Rett syndrome is a neurodevelopmental disorder predominately affecting females. The majority of patients have epilepsy in the early stages of the disease. This study evaluates the clinical course of epilepsy and the effect of antiepileptic drug treatment in Rett syndrome using retrospective data analysis. Epilepsy was...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073811408422
更新日期：2011-11-01 00:00:00
abstract：:The clinical and laboratory data of four pediatric patients and one adult patient with inverted duplication (inv dup) (15) are reported. The most evident findings were dysmorphic features with frontal bossing; genital abnormalities, such as macropenis or hypospadias; mental retardation; autistic behavior; and seizures...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307380001500605
更新日期：2000-06-01 00:00:00
abstract：:Our objective was to delineate the educational and behavioral differences between learning disabled children with and without attention-deficit hyperactivity disorder (ADHD). A restrospective (TROHOC) multimeasure comparative design was employed. Parents' and teachers' questionnaires (ANSER system) pertaining to atten...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307389801300606
更新日期：1998-06-01 00:00:00
abstract：:Nonconvulsive status epilepticus is a prolonged and continuous state of increased unawareness without overt motor seizures linked with repetitive generalized epileptic discharges. In children, it may occur de novo but more commonly may complicate a preexisting epileptic disorder. We report on a 2-year-old female who p...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307380101600310
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Rufinamide, a triazole derivative, is a new-generation antiseizure medication with a novel mechanism of action. We evaluated the efficacy and safety of rufinamide treatment in children with epilepsy younger than 4 years at our center. METHODS:In this retrospective study, we included children younger than 4 ...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073820967159
更新日期：2021-03-01 00:00:00
abstract：:To determine if parents can successfully teach their children with autism spectrum disorders to become better sleepers, we piloted small group parent education workshops focused on behavioral sleep strategies. Workshops consisted of three 2-hour sessions conducted over consecutive weeks by 2 physicians. Curricula incl...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073808331348
更新日期：2009-08-01 00:00:00
abstract：:This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. This was a randomized, double-blind study of riboflavin (200 mg daily) versus placebo in 48 children. The primary efficacy measure was the number of patients achieving a 50% or greater reduction in the number of migrai...
journal_title：Journal of child neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/0883073808318053
更新日期：2008-11-01 00:00:00
abstract：:At present, both migraine and tension-type headaches in children are believed to be chronic primary headaches. Meningeal signs in both cases are ignored or not examined, and the neurologic status is considered normal. This is the first study that focuses on meningeal signs in children with chronic headaches. The study...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/08830738060210050601
更新日期：2006-05-01 00:00:00
abstract：:This article describes a case of pyruvate dehydrogenase deficiency in a 3-year-old boy who presented generalized hypotonia, severe psychomotor development delay, and generalized and partial seizures and was refractory to antiepileptic drugs. After the diagnosis, the patient was put on a ketogenic diet. Six months late...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073812436424
更新日期：2012-12-01 00:00:00
abstract：:Patients with neurofibromatosis 1 show neurocognitive deficits including abnormal visuospatial performance, but oculomotor behavior has not been studied. We recorded saccades in neurofibromatosis 1 and normal children, ages 6 to 12 years. Patients showed increased latency and diminished amplitude to more eccentric tar...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/08830738030180050301
更新日期：2003-05-01 00:00:00
abstract：:Solitary tumefactive demyelination is rare in children, and the diagnosis is often conferred after brain biopsy. The authors report 3 children with solitary tumefactive demyelination and provide clinical and paraclinical clues to aid the clinician in reaching a diagnosis using a noninvasive approach. ...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073811401402
更新日期：2011-08-01 00:00:00
abstract：:The frequency of cranial autonomic symptoms in children affected by primary headaches is uncertain. The aim of our study was to estimate the frequency of symptoms in pediatric headaches and correlate it with main migraine characteristics. A questionnaire investigating the presence of cranial autonomic symptoms was adm...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073814535494
更新日期：2015-02-01 00:00:00
abstract：AIM:To investigate the impact of concussion on pupillary function in children by examining pupillometric parameters and assessing for differences in children reporting photosensitivity. METHODS:Retrospective chart review was performed of pediatric patients referred for visual symptoms after concussion from 2017 to 201...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073820964040
更新日期：2021-03-01 00:00:00
abstract：:Subacute necrotizing encephalomyelopathy (Leigh syndrome) refers to a nebulous disease entity characterized by lactic acidosis, a wide variety a clinical manifestations, and a consistent conglomeration of pathologic findings. Several abnormalities in metabolism have been delineated in association with Leigh syndrome, ...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307389901400510
更新日期：1999-05-01 00:00:00
abstract：:In this study we investigated centrally mediated parasympathetic regulation of modulated cardiac vagal tone among children with severe cyanotic and pallid breath-holding spells by examining respiratory sinus arrhythmia. Respiratory sinus arrhythmia was evaluated in 41 children; 17 subjects with cyanotic breath-holding...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307389801300905
更新日期：1998-09-01 00:00:00
abstract：:Children and adolescents with the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnosis of attention-deficit hyperactivity disorder (ADHD) can have comorbid conditions such as conduct disorder, oppositional defiant disorder, and obsessive-compulsive disorder (comorbid type). The purpose of our st...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/08830738040190020201
更新日期：2004-02-01 00:00:00
abstract：:Ischemic stroke in the young is uncommon, but we currently evaluate at least one young stroke patient at our institutions each week. We undertook this chart review of strokes in patients between the ages of 6 months and 39 years to review all conditions associated with, and thus possibly contributory to, the stroke. W...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307389300800311
更新日期：1993-07-01 00:00:00
abstract：:An infant newly diagnosed with propionic acidemic coma was managed successfully with total parenteral nutrition (TPN) and continuous infusion of insulin. The urinary excretion of 3-hydroxypropionic acid was reduced to 3% of the admission value in 4 days, gradually decreasing to 1.5% in 16 days. The treatment did not p...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/08830738920070011411
更新日期：1992-04-01 00:00:00
abstract：:Maternal intrauterine inflammation has been implicated in the development of periventricular leukomalacia and white matter injury in the neonate. We hypothesized that intrauterine endotoxin administration would lead to microstructural changes in the neonatal rabbit white matter in vivo that could be detected at birth ...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073809338213
更新日期：2009-09-01 00:00:00
abstract：:Tics, patterned movements distinct from stereotypies, myoclonus, and other hyperkinetic movements, are quite common in children, particularly among those with developmental and psychiatric disorders. Thus, tics can indicate the presence of atypical neurodevelopment or broader difficulties with cognition or mood. Tics ...
journal_title：Journal of child neurology
pub_type： 杂志文章,评审
doi：10.1177/08830738060210080401
更新日期：2006-08-01 00:00:00
abstract：:Using resting state functional magnetic resonance imaging (MRI), we aim to understand the neurologic basis of improved function in children with hemiplegic cerebral palsy treated with constraint-induced movement therapy. Eleven children including 4 untreated comparison subjects diagnosed with hemiplegic cerebral palsy...
journal_title：Journal of child neurology
pub_type： 杂志文章,多中心研究
doi：10.1177/0883073815588995
更新日期：2016-02-01 00:00:00
abstract：:Mitochondrial medicine provides a metabolic perspective on the pathology of conditions linked with inadequate oxidative phosphorylation. Dysfunction in the mitochondrial machinery can result in improper energy production, leading to cellular injury or even apoptosis. Clinical presentations are often subtle, so clinici...
journal_title：Journal of child neurology
pub_type：
doi：10.1177/0883073814537379
更新日期：2014-09-01 00:00:00
abstract：:Morvan syndrome is a rare autoimmune disease named after the French physician Augustin Marie Morvan. It is characterized by multiple, irregular contractions of the long muscles, weakness, pruritus, hyperhidrosis, insomnia, and delirium. Here, we describe a 17-year-old young man, previously diagnosed with B-cell lympho...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073809356108
更新日期：2010-08-01 00:00:00
abstract：:The aim of the present study was to assess the emotional and cognitive aspects of social cognition among patients with rolandic epilepsy. A computerized neuropsychological battery was used for cognitive evaluation. Affective and cognitive social cognition were evaluated using two computerized Theory of Mind tasks. Cog...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073811414420
更新日期：2012-02-01 00:00:00
abstract：:Many neurodegenerative diseases can be misdiagnosed as cerebral palsy. The correct diagnosis is reached when the condition recurs in families or when there are specific clinical signs. The clinical and imaging features of 3 children, from 2 unrelated families, presenting with global developmental delay and dystonia ar...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073813512026
更新日期：2014-11-01 00:00:00
abstract：:The relationships between the Expanded Hammersmith Functional Motor Scale (HFMSE) and genotype and motor and respiratory outcomes were examined in patients with spinal muscular atrophy types II and III (n = 70). The correlation between the HFMSE and Gross Motor Function Measure was r = 0.98. Correlations between HFMSE...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/0883073811420294
更新日期：2011-12-01 00:00:00
abstract：:Epilepsy, together with mental retardation, represents a common manifestation of chromosomal aberrations. Specific electroencephalographic (EEG) and epileptic patterns have been described in several chromosomal disorders, such as Angelman's syndrome, Miller-Dieker syndrome, Wolf-Hirschhorn syndrome, and ring 20 syndro...
journal_title：Journal of child neurology
pub_type： 杂志文章
doi：10.1177/088307380401900807
更新日期：2004-08-01 00:00:00
