Abstract:
:Young children with sickle cell disease are at risk of brain damage, including stroke. We tested the hypothesis that such patients are also at risk of cognitive impairment. We characterized the cognitive ability of kindergarten children to minimize the effect of disease-related school absence. The Memphis City Schools use the Developing Skills Checklist, a teacher-administered test given in the classroom, to assess kindergarten-appropriate skills. Data were obtained for 34 patients, who were matched to controls by gender, race, date of birth, school, and approximate income. Two controls were selected for each patient, and paired t-tests were used to compare patient's scores to composite control scores. Patients scored lower than controls in auditory discrimination (P < .01), and there was a trend (P < .10) toward lower patient scores in language. Deficits cannot be attributed to school absence and may predict academic problems for patients with sickle cell disease.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Steen RG,Hu XJ,Elliott VE,Miles MA,Jones S,Wang WCdoi
10.1177/088307380201700204subject
Has Abstractpub_date
2002-02-01 00:00:00pages
111-6issue
2eissn
0883-0738issn
1708-8283journal_volume
17pub_type
杂志文章abstract::Neurologic toxicity may occur as a direct effect of cancer and its therapy or indirectly because of a dysfunctional immune system. The authors report the development of axonal neuropathy, myelopathy, and leucoencephalopathy associated with glutamic acid decarboxylase-65 (GAD) antibodies in 4 children with progressive ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808315617
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:The classic phenotype of CLN2 disease (neuronal ceroid lipofuscinosis type 2) typically manifests between ages 2 and 4 years with a predictable clinical course marked by epilepsy, language developmental delay, and rapid psychomotor decline. Atypical phenotypes exhibit variable time of onset, symptomatology, ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820977997
更新日期:2020-12-23 00:00:00
abstract::Autosomal recessive spinal muscular atrophy is caused by mutations in the survival motoneuron (SMN) gene. There are two nearly identical copies of this gene present on chromosome 5q13; however, only the telomeric copy of this gene is affected in spinal muscular atrophy. In this study, we describe a new method to detec...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180041301
更新日期:2003-04-01 00:00:00
abstract::There is strong evidence for a loss of habituation during cognitive processing in migraine as measured by P300 and contingent negative variation in adults. Event-related potentials evoked by an oddball paradigm have not yet been studied in children and adolescents suffering from different primary headache types. We re...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389801300703
更新日期:1998-07-01 00:00:00
abstract::The aim of this study is to investigate the efficacy and tolerability of topiramate in a large number of children with West syndrome. The authors performed a retrospective, questionnaire-based data collection in specialized epilepsy units in Germany. Patients with West syndrome and hypsarrhythmia could be included if ...
journal_title:Journal of child neurology
pub_type: 杂志文章,多中心研究
doi:10.1177/0883073807300535
更新日期:2007-03-01 00:00:00
abstract::Growth failure is nearly universal in spinal muscular atrophy type 1 and common in type 2, although acuity is often underappreciated at initial diagnosis. We reviewed 44 consecutive spinal muscular atrophy patients (28 type 1, 16 type 2) under 3 years at initial presentation. Growth failure was conventionally defined:...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811415680
更新日期:2012-07-01 00:00:00
abstract::Neuroblastoma is, at once, the most common and deadly extracranial solid tumor of childhood. Efforts aimed at targeting the neural characteristics of these tumors have taught us much about neural crest cell biology, apoptosis induction in the nervous system, and neurotrophin receptor signaling and intracellular proces...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073813483173
更新日期:2013-06-01 00:00:00
abstract::The purpose of this study was to determine whether children with epilepsy undergoing valproate therapy and who are otherwise healthy have lower levels of serum and muscle carnitine. A total of 50 patients with epilepsy, 3 to 14 years of age, who were treated solely with valproate and free of abnormal neurologic findin...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/0883073808321060
更新日期:2009-01-01 00:00:00
abstract::This review summarizes what is known about the neurobiology of specific language impairment. Despite its name, specific language impairment is frequently not specific. It is common to find associated impairments in motor skills, cognitive function, attention, and reading in children who meet criteria for specific lang...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738040190070101
更新日期:2004-07-01 00:00:00
abstract::The spectrum of clinical disease in juvenile Huntington's disease differs from that seen in adults. Younger patients often present with seizures, dystonia and rigidity. The mechanism and type of seizures, timing of onset and electrographic features have not been well characterized in either adults or children. We desc...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::We reviewed cranial sonographic studies done on 108 normal newborn infants to determine the prevalence and variability in size of the cavum septi pellucidi (CSP). Infants were classified according to gestational age by 2-week intervals. At 24 weeks, only four normal scans were identified. Between 26 and 34 weeks, ten ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389200700106
更新日期:1992-01-01 00:00:00
abstract::A pseudotumoral presentation of acute hemicerebellitis is rare in pediatric age. The authors report a new single case study of a 7-year-old child with pseudotumoral unilateral cerebellitis mimicking an intracranial tumor, which clinically presented itself with signs of intracranial hypertension and mild contralateral ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814545114
更新日期:2015-03-01 00:00:00
abstract::Ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive disease characterized by early-onset and slowly progressive cerebellar ataxia, areflexia, and peripheral neuropathy. Ocular apraxia is most prominent in the early stage of the disease, by contrast, hypoalbuminemia, hypercholesterolemia, and cogniti...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808314959
更新日期:2008-08-01 00:00:00
abstract::Clinical and subclinical seizures occur frequently among children with autistic spectrum disorders. Electrographic status epilepticus in sleep, or continuous spike-wave in slow-wave sleep, is a typical feature of acquired epileptic aphasia and Landau-Kleffner syndrome. Seizures and epilepsy are more common among child...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307380401900106
更新日期:2004-08-01 00:00:00
abstract::Primary hypertension is associated with decreased performance on neurocognitive testing and a blunted cerebrovascular reactivity to hypercapnia. Parents of 14 children with hypertension and prehypertension completed the Behavior Rating Inventory of Executive Functions. Children underwent 24-hour ambulatory blood press...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813494264
更新日期:2015-04-01 00:00:00
abstract::Two boys, aged 7 and 12 years, with nondominant (right) hemispheric acquired vascular lesions and left visual-field disturbances had right spatial constructional disabilities, contralateral to that which would be expected. These unusual disturbances may represent the previously unreported phenomena of ipsilateral negl...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900109
更新日期:1994-01-01 00:00:00
abstract::Using resting state functional magnetic resonance imaging (MRI), we aim to understand the neurologic basis of improved function in children with hemiplegic cerebral palsy treated with constraint-induced movement therapy. Eleven children including 4 untreated comparison subjects diagnosed with hemiplegic cerebral palsy...
journal_title:Journal of child neurology
pub_type: 杂志文章,多中心研究
doi:10.1177/0883073815588995
更新日期:2016-02-01 00:00:00
abstract::Aminoacyl-transfer ribonucleic acid (RNA) synthetases (ARSs) are a group of enzymes required for the first step of protein translation. Each aminoacyl-transfer RNA synthetase links a specific amino acid to its corresponding transfer RNA component within the cytoplasm, mitochondria, or both. Mutations in ARSs have been...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814553272
更新日期:2015-07-01 00:00:00
abstract::Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine the prevalence of sleep problems in children with the common neurodevelopmental disorder neurofibromatosis type 1, a cross-sectional study was performed on 129...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813500849
更新日期:2013-11-01 00:00:00
abstract::Understanding patterns of medical comorbidity in attention-deficit/hyperactivity disorder (ADHD) may lead to better treatment of affected individuals as well as aid in etiologic study of disease. This article provides the first systematic evaluation on the medical comorbidity of ADHD in a nationally representative sam...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073816653782
更新日期:2016-10-01 00:00:00
abstract::We report 10 years' follow-up of the previously described family with a novel mutation of the KCNA1 gene. The family consisted of 3 affected boys (first seen at ages 3, 11, and 12) and their affected mother and asymptomatic father and sister. They clinically presented with diffuse myokymia, muscle cramps, and lower li...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812457461
更新日期:2013-11-01 00:00:00
abstract::Two siblings with familial encephalopathy, calcification of the basal ganglia, and cerebrospinal fluid lymphocytosis, constituting the triad of Aicardi-Goutieres syndrome, are reported. This syndrome resembles congenital intrauterine infections, which must be meticulously excluded. Aicardi-Goutieres syndrome is extrem...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101601009
更新日期:2001-10-01 00:00:00
abstract::Phantosmia is an infrequently reported and poorly understood qualitative olfactory disorder characterized by the perception of a frequently unpleasant odor in the absence of an odorant stimulus. Peripheral phantosmia is hypothesized to involve abnormally active olfactory receptor neurons while central phantosmia is th...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812450616
更新日期:2013-06-01 00:00:00
abstract::The prognosis in infants with brain tumors has historically been very poor. This study reviews 16 infants under the age of 12 months with brain tumors who presented to our institution between 1988 and 1999. The aim was to describe the clinical presentation, diagnosis, and management of these patients and to establish ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380401900605
更新日期:2004-06-01 00:00:00
abstract::To evaluate the effect of early treatment of congenital hypothyroidism on central nervous system development, auditory brainstem evoked potentials were determined in 32 patients with hyperthyrotropinemia diagnosed during neonatal screening. The patients included 27 with congenital hypothyroidism and 5 with transient h...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700707
更新日期:2002-07-01 00:00:00
abstract::Smith-Lemli-Opitz syndrome is a unique malformation syndrome characterized by a defect in cholesterol biosynthesis, which is very rare among populations in Middle and East Asia. The authors identified compound heterozygous mutations ([p.Arg352Trp] + [p.Lys376ArgfsX37]) in a Korean girl with clinical and laboratory fea...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807307099
更新日期:2007-11-01 00:00:00
abstract:AIM:We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center. METHOD:Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820916260
更新日期:2020-07-01 00:00:00
abstract::Idiopathic photosensitive occipital lobe epilepsy is a reflex, age- and localization-related syndrome. We describe the clinical and electroencephalographic features, therapy, and outcome of 16 children/adolescents with this syndrome. The cohort included 2 sets of siblings and 7 patients with other first- or second-deg...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812473366
更新日期:2014-03-01 00:00:00
abstract::Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral pa...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738060210050201
更新日期:2006-05-01 00:00:00
abstract::A 14-year-old boy with an episode of acute weakness resembling acute demyelinating encephalomyelitis and polyradiculoneuritis after a febrile illness is described. Molecular analysis showed a mutation at codon 164 of the connexin 32 gene. Neuroradiological and neurophysiological follow-up is reported during acute and ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809344119
更新日期:2010-06-01 00:00:00