Animal models of germinal matrix hemorrhage.

Abstract:

:Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral palsy, seizures, and learning disabilities. Understanding the causative factors and the pathogenesis of subsequent brain damage is important if germinal matrix hemorrhage is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. A number of animal species, including mice, rats, rabbits, sheep, pigs, dogs, cats, and primates, have been used to model germinal matrix hemorrhage. This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage.

journal_name

J Child Neurol

authors

Balasubramaniam J,Del Bigio MR

doi

10.1177/08830738060210050201

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

365-71

issue

5

eissn

0883-0738

issn

1708-8283

journal_volume

21

pub_type

杂志文章,评审
  • Tests for juvenile myasthenia gravis: comparative diagnostic yield and prediction of outcome.

    abstract::The clinical picture, family history, laboratory data, treatment modalities, and outcome in 27 juvenile myasthenics seen over a 25-year period are presented. Onset was after 10 years of age in the majority of patients. Half presented with ocular signs, the other half with generalized-onset myasthenia. Half of those wi...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/088307389300800422

    authors: Afifi AK,Bell WE

    更新日期:1993-10-01 00:00:00

  • Successful treatment of cytomegalovirus polyradiculopathy in a 9-year-old child with congenital human immunodeficiency virus infection.

    abstract::Cytomegalovirus lumbosacral polyradiculopathy is a well-documented complication of human immunodeficiency virus in adults who have a CD4 count of less than 40/microL. Patients present with an acute ascending flaccid paralysis of the lower limbs with areflexia, paresthesia, and urinary and bowel symptoms. However, it a...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073808322671

    authors: Sohal A,Riordan A,Mallewa M,Solomon T,Kneen R

    更新日期:2009-02-01 00:00:00

  • Right hemisphere dysfunction in subjects with attention-deficit disorder with and without hyperactivity.

    abstract::The attention-deficit disorder, with and without hyperactivity, is associated with defective attention, response inhibition and, in attention-deficit disorder with hyperactivity, with motor restlessness. In adults, inattention, defective response inhibition, and impersistence are more commonly seen in right hemisphere...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389701200207

    authors: García-Sánchez C,Estévez-González A,Suárez-Romero E,Junqué C

    更新日期:1997-02-01 00:00:00

  • Clinical experience on headache in children: analysis of 92 cases.

    abstract::We analyzed, retrospectively, 92 patients with headache to determine the changes in the order of frequency of causes with the development of neuroimaging studies and its efficacy in the investigation of patients with headache. The type of headache was redefined according to the International Headache Society (IHS) dia...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389801300502

    authors: Aysun S,Yetük M

    更新日期:1998-05-01 00:00:00

  • NeuroDebian Virtual Machine Deployment Facilitates Trainee-Driven Bedside Neuroimaging Research.

    abstract::Freely available software, derived from the past 2 decades of neuroimaging research, is significantly more flexible for research purposes than presently available clinical tools. Here, we describe and demonstrate the utility of rapidly deployable analysis software to facilitate trainee-driven translational neuroimagin...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073816668113

    authors: Cohen A,Kenney-Jung D,Botha H,Tillema JM

    更新日期:2017-01-01 00:00:00

  • Pontine Tegmentum Lesions Accompanying Myelitis During an Enterovirus Outbreak: Differential Diagnosis and Outcome.

    abstract:AIM:To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis. METHOD:We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073820911737

    authors: Bastemur M,Gocmen R,Parlak S,Yuksel D,Arslan EA,Okten AY,Iscan A,Ekici B,Anlar B

    更新日期:2020-07-01 00:00:00

  • Ocular manifestations of Donnai-Barrow syndrome.

    abstract::Donnai-Barrow syndrome is a rare autosomal recessive disorder first described in 1993. This report presents ocular manifestations of this rare autosomal recessive disorder through 2 additional cases. Ocular features include hypertelorism, down-slanting palpebral fissures, iris coloboma, high myopia, and retinal detach...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807301933

    authors: Patel N,Hejkal T,Katz A,Margalit E

    更新日期:2007-04-01 00:00:00

  • Pontine Tegmental Cap Dysplasia in an Extremely Preterm Infant and Review of the Literature.

    abstract::Pontine tegmental cap dysplasia is a rare hindbrain malformation syndrome with a hypoplastic pons, a tissue protrusion into the fourth ventricle, and cranial nerve dysfunction. We here report clinical, imaging, and genetic findings of the first extremely low-birth-weight preterm infant with pontine tegmental cap dyspl...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/0883073816680748

    authors: Picker-Minh S,Hartenstein S,Proquitté H,Fröhler S,Raile V,Kraemer N,Apeshiotis S,Leipoldt M,Kalache KD,Morris-Rosendahl D,Boltshauser E,Chen W,Kaindl AM

    更新日期:2017-03-01 00:00:00

  • Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging.

    abstract::Tuberous sclerosis complex is a disease that affects many organs, including the central nervous system. Nervous system involvement in the form of hamartomas often results in seizures. In this study we wanted to determine the outcome of epilepsy in tuberous sclerosis complex and determine whether interictal electroence...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307380001500203

    authors: Husain AM,Foley CM,Legido A,Chandler DA,Miles DK,Grover WD

    更新日期:2000-02-01 00:00:00

  • Valuation of Quality of Life in Pediatric Disability in a Developing Country.

    abstract::This article assessed how Indian providers and mothers value quality of life in pediatric disabilities, hypothesizing lower values with increasing disability, lower values among providers than mothers, and lower values among mothers with versus mothers without a disabled child. We asked 175 participants: "If born tomo...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073818773941

    authors: Spiegel E,Jondhale S,Brajkovic I,Nesbit KC,Allen IE,Bhutani V,Kumar P,Partridge JC

    更新日期:2018-08-01 00:00:00

  • Plasma baclofen levels in children receiving continuous intrathecal baclofen infusion.

    abstract::To determine the plasma baclofen concentrations of children undergoing continuous intrathecal baclofen infusion for treatment of cerebral spasticity, we assayed plasma samples from six children, 8 to 18 years of age, who were receiving intrathecal baclofen at constant rates of 77 to 400 micrograms/day. Plasma levels w...

    journal_title:Journal of child neurology

    pub_type: 临床试验,杂志文章

    doi:10.1177/088307389901400611

    authors: Albright AL,Shultz BL

    更新日期:1999-06-01 00:00:00

  • Intracranial meningiomas in children: report of 27 new cases and critical analysis of 440 cases reported in the literature.

    abstract::We accumulated 440 cases of intracranial meningiomas in patients under 16 years of age, and another 27 personal. This review confirms the existence of specific clinical features of spontaneous and radiation-induced meningioma in children. In addition, we discuss various points that suggest a more aggressive behavior o...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/08830738060210010801

    authors: Caroli E,Russillo M,Ferrante L

    更新日期:2006-01-01 00:00:00

  • A Model Program for Translational Medicine in Epilepsy Genetics.

    abstract::Recent technological advances in gene sequencing have led to a rapid increase in gene discovery in epilepsy. However, the ability to assess pathogenicity of variants, provide functional analysis, and develop targeted therapies has not kept pace with rapid advances in sequencing technology. Thus, although clinical gene...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073816685654

    authors: Smith LA,Ullmann JF,Olson HE,Achkar CM,Truglio G,Kelly M,Rosen-Sheidley B,Poduri A

    更新日期:2017-03-01 00:00:00

  • Paroxysmal facial itch: a presenting sign of childhood brainstem glioma.

    abstract::Two children with neurofibromatosis and a chief complaint of severe, episodic, unilateral facial itching were found to have brainstem glioma. Initial computerized tomography of the brain was thought to be normal, but the brainstem tumor was subsequently demonstrated on magnetic resonance imaging. The paroxysmal facial...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307388800300308

    authors: Summers CG,MacDonald JT

    更新日期:1988-07-01 00:00:00

  • A diffusion tensor imaging study of the cerebellar pathways in children with autism spectrum disorder.

    abstract::Children with autistic spectrum disorder are known to have histopathological abnormalities in the cerebellum. Diffusion tensor imaging has been utilized to study abnormalities in connectivity and microintegrity in brains of such children. A region of interest approach was adopted to study cerebellar outflow and inflow...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073809358765

    authors: Sivaswamy L,Kumar A,Rajan D,Behen M,Muzik O,Chugani D,Chugani H

    更新日期:2010-10-01 00:00:00

  • Intravenous immunoglobulin as adjunctive therapy for juvenile spasms.

    abstract::Intravenous immunoglobulin has been reported to be an effective treatment for infantile spasms. Juvenile spasms are electrically and clinically similar to infantile spasms but occur in a later age group. We retrospectively reviewed the charts of five children (aged 4.5-11.5 years) at our institution. Their primary sei...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738030180061001

    authors: Bingel U,Pinter JD,Sotero de Menezes M,Rho JM

    更新日期:2003-06-01 00:00:00

  • Characteristic brain magnetic resonance imaging (MRI) findings in neonates with tuberous sclerosis complex.

    abstract::We describe the brain magnetic resonance imaging (MRI) findings in eight neonates with tuberous sclerosis complex to further delineate the spectrum of characteristic findings in these patients. In addition to the previously described characteristic brain MRI findings in neonates, which included cortical tuber, transma...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738060210042301

    authors: Arca G,Pacheco E,Alfonso I,Duchowny MS,Melnick SJ

    更新日期:2006-04-01 00:00:00

  • Epidemiology of childhood Guillain-Barré syndrome as a cause of acute flaccid paralysis in Honduras: 1989-1999.

    abstract::The objective of this study was to investigate the incidence of acute flaccid paralysis in the pediatric population of Honduras over an 11-year period, determine what percentage of acute flaccid paralysis was Guillain-Barré syndrome, and identify the epidemiologic features of Guillain-Barré syndrome. There were 546 ch...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738030180110801

    authors: Molinero MR,Varon D,Holden KR,Sladky JT,Molina IB,Cleaves F

    更新日期:2003-11-01 00:00:00

  • Effects of postnatal dexamethasone exposure on the developmental outcome of premature infants.

    abstract::Extremely low birth weight premature infants are at risk for poor neurodevelopmental outcome. Postnatal dexamethasone has often been used in premature infants to prevent or treat bronchopulmonary dysplasia, and this drug is thought by some to affect neurodevelopmental outcome. We retrospectively examined the effect of...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807309232

    authors: Needelman H,Evans M,Roberts H,Sweney M,Bodensteiner JB

    更新日期:2008-04-01 00:00:00

  • Acute transverse myelitis in a 15-month-old girl: report of a case with MRI findings.

    abstract::A 15-month-old girl demonstrated progressive weakness in all limbs. Magnetic resonance imaging (MRI) on admission revealed (1) diffuse and symmetric cervical cord swelling, (2) diffuse decrease and increase in signal intensity within the affected cord on T1- and T2-weighted images, respectively, (3) preserved anatomic...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389200700214

    authors: Yamamoto K,Nakagawa H,Kato S,Abe J,Inoue S,Shibuya H

    更新日期:1992-04-01 00:00:00

  • Gingival enlargement in children treated with antiepileptics.

    abstract::This study was conducted to determine the occurrence, severity, and risk factors of gingival enlargement in children treated with valproate and other nonvalproate antiepileptic drugs. A cross-sectional study was carried out in which data obtained from 68 epileptic children under treatment were compared with those from...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738040190120901

    authors: Tan H,Gürbüz T,Dağsuyu IM

    更新日期:2004-12-01 00:00:00

  • Attentional disturbance after pediatric closed head injury.

    abstract::The influence of severity of closed head injury and age on attentional functioning was prospectively investigated in 36 children (age range, 7 to 16 years) 6 months after injury. Children were placed into mild, moderate, and severe injury groups using established neurologic criteria. Each child received the Wechsler I...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389300800410

    authors: Kaufmann PM,Fletcher JM,Levin HS,Miner ME,Ewing-Cobbs L

    更新日期:1993-10-01 00:00:00

  • Brain abnormalities in tuberous sclerosis complex.

    abstract::Tuberous sclerosis complex is an autosomal dominant multisystem disorder. Spontaneous mutations occur in up to 60% of patients with gene loci located on chromosomes 9q34 (TSC1) and 16p13 (TSC2). Diagnosis is established with the identification of various neurocutaneous markers and multiple organ system hamartomas. The...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/08830738040190090401

    authors: DiMario FJ Jr

    更新日期:2004-09-01 00:00:00

  • Computerized Cognitive Testing in the Management of Youth Sports-Related Concussion.

    abstract::Computerized neurocognitive testing has become a growing practice across medical populations, but particularly within sports medicine and the management of sports-related concussion. Although traditional neuropsychological measures are solely administered and interpreted by neuropsychologists, computerized cognitive t...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/0883073814559645

    authors: De Marco AP,Broshek DK

    更新日期:2016-01-01 00:00:00

  • Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child.

    abstract::We report a divergent ependymal tumor of the posterior fossa (ependymoblastoma/anaplastic ependymoma) observed in an 8-year-old boy. The tumor showed the histological pattern typical of an ependymoblastoma (tubular-papillary fetaloid architecture with stratification of the tumor cells) next to areas in which findings ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073808314160

    authors: Ortiz J,Otero A,Bengoechea O,Gonçalves J,Sousa P,Figols J,Bullón A

    更新日期:2008-09-01 00:00:00

  • Meningismus is a commonly overlooked finding in tension-type headache in children and adolescents.

    abstract::At present, both migraine and tension-type headaches in children are believed to be chronic primary headaches. Meningeal signs in both cases are ignored or not examined, and the neurologic status is considered normal. This is the first study that focuses on meningeal signs in children with chronic headaches. The study...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738060210050601

    authors: Almazov I,Brand N

    更新日期:2006-05-01 00:00:00

  • Impaired social behavior in children with benign childhood epilepsy with centrotemporal spikes.

    abstract::The aim of the present study was to assess the emotional and cognitive aspects of social cognition among patients with rolandic epilepsy. A computerized neuropsychological battery was used for cognitive evaluation. Affective and cognitive social cognition were evaluated using two computerized Theory of Mind tasks. Cog...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073811414420

    authors: Genizi J,Shamay-Tsoory SG,Shahar E,Yaniv S,Aharon-Perez J

    更新日期:2012-02-01 00:00:00

  • Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia.

    abstract::We recruited 128 neonates with hyperbilirubinemia over a 5-year period (1995-2000) to study the short- and long-term effects of hemolytic hyperbilirubinemia on the auditory brainstem pathway and neurodevelopmental status. These children were divided into two groups: (1) a hemolytic group (n = 29; ABO incompatibility [...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738060210061301

    authors: Chen WX,Wong VC,Wong KY

    更新日期:2006-06-01 00:00:00

  • Gelastic seizure with hypothalamic hamartoma: proton magnetic resonance spectrometry and ictal electroencephalographic findings in a 4-year-old girl.

    abstract::Gelastic seizure is a rare symptom often associated with hypothalamic hamartoma. We present here a 4-year-old girl with gelastic epilepsy caused by hypothalamic hamartoma and report the magnetic resonance spectrometry and electroencephalographic (EEG) findings. At the age of 2 1/2 years, she developed brief, repetitiv...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307380201700111

    authors: Wakai S,Nikaido K,Nihira H,Kawamoto Y,Hayasaka H

    更新日期:2002-01-01 00:00:00

  • Blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy: a cross-sectional study.

    abstract::This cross-sectional study was planned to study the blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy. A total of 60 epileptic children aged 3 months to 12 years, that were on valproic acid monotherapy for at least 3 months, were enrolled and divided into 2 groups, a low-dose gro...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073810377235

    authors: Sharma S,Gulati S,Kabra M,Kalra V,Vasisht S,Gupta YK

    更新日期:2011-01-01 00:00:00