Abstract:
:Recent technological advances in gene sequencing have led to a rapid increase in gene discovery in epilepsy. However, the ability to assess pathogenicity of variants, provide functional analysis, and develop targeted therapies has not kept pace with rapid advances in sequencing technology. Thus, although clinical genetic testing may lead to a specific molecular diagnosis for some patients, test results often lead to more questions than answers. As the field begins to focus on therapeutic applications of genetic diagnoses using precision medicine, developing processes that offer more than equivocal test results is essential. The success of precision medicine in epilepsy relies on establishing a correct genetic diagnosis, analyzing functional consequences of genetic variants, screening potential therapeutics in the preclinical laboratory setting, and initiating targeted therapy trials for patients. The authors describe the structure of a comprehensive, pediatric Epilepsy Genetics Program that can serve as a model for translational medicine in epilepsy.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Smith LA,Ullmann JF,Olson HE,Achkar CM,Truglio G,Kelly M,Rosen-Sheidley B,Poduri Adoi
10.1177/0883073816685654subject
Has Abstractpub_date
2017-03-01 00:00:00pages
429-436issue
4eissn
0883-0738issn
1708-8283journal_volume
32pub_type
杂志文章abstract::The few cases of antiphospholipid syndrome that have been reported in neonates are believed to have resulted from a transplacental transfer of antiphospholipid antibodies. Here we report on a boy with a neonatal stroke revealing a de novo primary antiphospholipid, the mother being free of antiphospholipid antibodies. ...
journal_title:Journal of child neurology
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doi:10.1177/0883073811435238
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abstract:AIM:We characterize the pediatric postural orthostatic tachycardia syndrome (POTS) population seen at a single tertiary care referral center. METHOD:Retrospective chart review of all pediatric POTS patients seen in our center between 2015 and 2017. Pediatric POTS was defined as chronic, at least 3 months, symptoms of ...
journal_title:Journal of child neurology
pub_type: 杂志文章
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journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:
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abstract::The voltage-sensitive calcium channel probe 125I-omega-GVIA conotoxin has been shown to be a developmental marker in whole brain preparations of Swiss Webster mice. The present study looks more carefully at regional dissections of the mouse brain (cerebrum, cerebellum, and brain stem) at postnatal day 8 and postnatal ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900120
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abstract::The cerebellum is involved in motor and cognitive functions and behavior. Its role in controlling epileptic seizures has been demonstrated in the literature. Genetic factors can enhance epilepsy susceptibility when the cerebellum is damaged. We examined the occurrence and features of epilepsy, intelligence, and psychi...
journal_title:Journal of child neurology
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doi:10.1177/08830738030180011001
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abstract::The potential benefits of functional magnetic resonance imaging (MRI) for the investigation of normal development have been limited by difficulties in its use with children. We describe the practical aspects, including failure rates, involved in conducting large-scale functional MRI studies with normal children. Two h...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738020170122201
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journal_title:Journal of child neurology
pub_type: 历史文章,杂志文章
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abstract::The ultimate goal for management of patients with cerebral palsy is to help them grow up to become as independent as possible, learn to make their own choices in life, and pursue their own dreams. Optimal mobility is crucial to achieving independence and is also necessary for better health and quality of life in these...
journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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更新日期:2014-11-01 00:00:00
abstract:AIM:The present study aimed to investigate whether the response variability of infants to modified constraint-induced movement therapy and bimanual therapy are associated with different types of brain lesions. METHOD:Infants with unilateral cerebral palsy (N = 22) ages 8-15 months (mean = 10.95, standard deviation = 2...
journal_title:Journal of child neurology
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doi:10.1177/0883073818801632
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journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813517294
更新日期:2014-05-01 00:00:00
abstract::Neonatal alloimmune thrombocytopenia results from platelet-antigen incompatibility between mother and fetus, leading to antibody-mediated destruction of fetal platelets. With a prevalence of 1 in 1000 births, approximately 4000 infants born in the United States each year develop neonatal alloimmune thrombocytopenia. T...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738010160111001
更新日期:2001-11-01 00:00:00
abstract::If behavior results from brain function, some evidence of dysfunction could be expected in children with major behavioral problems. Yet, neurophysiologic studies in these children are frequently normal. We hypothesized a relationship between maturational asymmetry and behavior, given the role of hemispheric imbalance ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901400206
更新日期:1999-02-01 00:00:00
abstract::To report the authors' experience with diagnosis and management of Dravet syndrome, or severe myoclonic epilepsy in infancy, in the era of commercially available genetic testing, the authors performed a retrospective study of 16 patients diagnosed with Dravet syndrome at a tertiary care pediatric epilepsy center. They...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807300294
更新日期:2007-02-01 00:00:00
abstract::This article assessed how Indian providers and mothers value quality of life in pediatric disabilities, hypothesizing lower values with increasing disability, lower values among providers than mothers, and lower values among mothers with versus mothers without a disabled child. We asked 175 participants: "If born tomo...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818773941
更新日期:2018-08-01 00:00:00
abstract::Healthy Chinese individuals (n = 168), aged from 24 hours to 30 years, were studied to establish the following normal values: (1) motor conduction velocity, distal latency, amplitude, and F-wave velocity in the median, ulnar, tibial, and peroneal nerves; (2) H-reflex velocity and latency in the tibial nerve for all su...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389701200102
更新日期:1997-01-01 00:00:00
abstract::Establishing consistency between cerebral palsy registries in reporting of new cases enables more effective collaboration in terms of researching predisposing factors. To identify antenatal and intrapartum risk factors for cerebral palsy in the Estonian population, we undertook a matched case-control study of 153 chil...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200080401
更新日期:2005-08-01 00:00:00
abstract::Multiple sclerosis onset in youth is increasingly recognized. A systematic review was conducted to assess incidence and prevalence of pediatric-onset multiple sclerosis, focusing on occurrence by age subgroups and disease course. A literature search for the period 1965-2018 was carried out, selecting population-based ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073819845827
更新日期:2019-10-01 00:00:00
abstract::Levetiracetam, one of the newer-generation antiepilepsy drugs, is not currently approved for use in children. Given its favorable efficacy, pharmacokinetic, and, particularly, safety profile in adults, we felt that it may be a useful antiepilepsy drug for children with refractory epilepsy. We treated 39 patients (mean...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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doi:10.1177/088307389601100408
更新日期:1996-07-01 00:00:00
abstract::This article describes a case of pyruvate dehydrogenase deficiency in a 3-year-old boy who presented generalized hypotonia, severe psychomotor development delay, and generalized and partial seizures and was refractory to antiepileptic drugs. After the diagnosis, the patient was put on a ketogenic diet. Six months late...
journal_title:Journal of child neurology
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doi:10.1177/0883073812436424
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abstract::We analyzed clinical and instrumental data of 403 consecutive newborns with gestational age from 24 to 32 weeks, admitted to the University-Hospital of Parma between January 2000 and December 2007, to evaluate the possible relationship between neonatal mortality and occurrence of neonatal seizures in very preterm newb...
journal_title:Journal of child neurology
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abstract::There has been increasing awareness that there are behavioral phenotypes in tuberous sclerosis complex with neuropsychiatric symptom complex such as autistic disorder and attention-deficit hyperactivity disorder (ADHD). However, the neurobiologic basis of autistic disorder in tuberous sclerosis complex is still unknow...
journal_title:Journal of child neurology
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abstract::The goal of the research was to point out the importance of early prespeech therapy for babies suffering from at-birth-acquired unilateral or bilateral lesion in the prespeech period of development. On the basis of existing studies and experience in the field, a protocol and methodology for the observation of the phon...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
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abstract::This is a case report of an otherwise healthy 2-year-old boy with a history of pica, associated with iron deficiency anemia. This boy was referred to our department for a neurologic evaluation because of an acute episode of sialorrhea, difficulty in speaking, dysphagia, and repeated swallowing movements. An uncertain ...
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