当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊下所有文献 > Highly potent activity of isopulegol-derived substituted octahydro-2H-chromen-4-ols against influenza A and B viruses.

Highly potent activity of isopulegol-derived substituted octahydro-2H-chromen-4-ols against influenza A and B viruses.

Abstract：

:A set of (-)-isopulegol derived octahydro-2H-chromen-4-ols was synthesized and evaluated in vitro for antiviral activity against panel of reference influenza virus strains differing in subtype, origin (human or avian) and drug resistance. Compound (4R)-11a produced via one-pot synthesis by interaction between (-)-isopulegol and acetone was found to exhibit an outstanding activity against a number of H1N1 and H2N2 influenza virus strains with selectivity index more than 1500. (4R)-11a was shown to be most potent at early stages of viral cycle. Good correlation between anti-viral activity and calculated binding energy to hemagglutinin TBHQ active site was demonstrated.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ilyina IV,Zarubaev VV,Lavrentieva IN,Shtro AA,Esaulkova IL,Korchagina DV,Borisevich SS,Volcho KP,Salakhutdinov NF

doi

10.1016/j.bmcl.2018.04.057

subject

Has Abstract

pub_date

2018-06-15 00:00:00

pages

2061-2067

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30369-X

journal_volume

28

pub_type

杂志文章

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