Abstract:
:We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results, second level investigations were performed. Endoscopy of the gastrointestinal tract with histological examination revealed a diagnosis of Crohn's disease. Vitamin K deficiency causes the formation of vitamin K-dependent clotting factors that cannot perform their pro-coagulant action. Consequently, patients present with hemorrhagic manifestations. Clinical and laboratory features observed in this patient show that the deficiency of vitamin K-dependent coagulation factors may reveal a complex clinical condition such as an inflammatory bowel disease.
journal_name
Ann Clin Lab Scijournal_title
Annals of clinical and laboratory scienceauthors
Agnello L,Bellia C,Lo Coco L,Vitale S,Coraci F,Bonura F,Gnoffo R,Napolitano M,Caruso A,Bivona G,Lo Sasso B,Ciaccio Msubject
Has Abstractpub_date
2014-07-01 00:00:00pages
337-40issue
3eissn
0091-7370issn
1550-8080pii
44/3/337journal_volume
44pub_type
杂志文章abstract::Tricho-rhino-phalangeal syndrome type I (TRPSI) is a rare autosomal dominant hereditary disorder characterized by sparse hair, bulbous nose, long philtrum, thin upper lip, and skeletal abnormalities including cone-shaped epiphyses, shortening of the phalanges, and short stature. TRPSI is caused by mutations in the TRP...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
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abstract::A retrospective study of acquired renal lesions in 42 renal transplants in children revealed a variety of histologic lesions. Although acute and chronic rejection changes were the most frequent, a number of metabolic, infectious, vascular, and other lesions were encountered. Renal biopsy allows rapid diagnosis of thes...
journal_title:Annals of clinical and laboratory science
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abstract::Traditional risk factors for coronary heart disease (CHD) include only the patient's age and family history and whether there is evidence of hypertension, elevated LDL, low HDL, diabetes or history of smoking. In recent years, considerable progress has been made in identifying a new generation of risk factors, includi...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
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abstract::We previously reported that proper dilution of sera that contain IgG monoclonal proteins (M-proteins) is necessary for accurate quantitation of serum albumin and M-protein concentrations separated by serum protein electrophoresis (SPE) using the Beckman PARAGON agarose electrophoresis system. We now report the signifi...
journal_title:Annals of clinical and laboratory science
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abstract::D-dimer is formed during activation of the coagulation system and is commonly assayed in order to diagnose disseminated intravascular coagulation, deep vein thrombosis, and pulmonary embolism. Enzyme-linked immunosorbent assay has been validated as the reference method, but it is a time-consuming procedure. The object...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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abstract::The erythrocyte abnormality most often associated with the toxic effects of commonly used drugs is premature destruction. The mechanisms of erythrocyte destruction include: denaturation of unstable hemoglobins, oxidation of sulfhydril groups in hemoglobin and the erythrocyte membrane in the presence of glucose-6-phosp...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
pub_type: 临床试验,杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Annals of clinical and laboratory science
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更新日期:2009-10-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Point-of-care testing (POCT) has been used for illicit substance screening in several settings, primarily in law enforcement and drug treatment centers. In this study, we evaluate the use of this screening approach in the emergency department (ED) of a tertiary-care, urban medical center. Aliquots of urine specimens w...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章,评审
doi:
更新日期:1975-01-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
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journal_title:Annals of clinical and laboratory science
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doi:
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
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abstract::In the course of a clinical comparison involving 204 parallel total creatine kinase (CK), creatine kinase-MB isoenzyme (CK-MB), and cardiac troponin I (cTnI) measurements, 12 patients were identified in whom cTnI was elevated while total CK was normal, as well as 2 patients in whom CK-MB was elevated while cTnI was no...
journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
abstract::Inflammation plays an important role in the pathogenesis of secondary damage after spinal cord injury (SCI). The present study explored the effect of sulforaphane (SFN), a potent anti-inflammatory extract of cruciferous vegetables, on the expression of two inflammatory mediators, metalloproteinase (MMP)-9 and TNF-α, i...
journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
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journal_title:Annals of clinical and laboratory science
pub_type: 杂志文章
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abstract::A total of 979 cardiac profiles were reviewed. Seventeen cases were found to have elevated CK-BB by electrophoresis and were misidentified by the immunoinhibition/immunoprecipitation technique as elevated creatine phosphokinase (CK-MB). Eleven of the 17 cases also had elevated lactate dehydrogenase (LD) LD-5/LD-1 rati...
journal_title:Annals of clinical and laboratory science
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