Abstract：
:Previous studies have suggested that there is a disproportionally higher risk of infection following traumatic brain injury (TBI). This predisposition to infection may be driven by a poorly understood, brain-specific response in the immune system after TBI. However, there is a lack of studies that have fully characterized TBI patients to understand the relationship between TBI and peripheral immune function. In the present study, markers for humoral immunity and cellular immunity were measured for up to 2 weeks in the peripheral blood of 37 patients with TBI in order to elucidate the time course and the type of the peripheral immune response following TBI. 12 relatively healthy individuals without TBI and other neurological diseases were enrolled into the control group. Our data indicated that TBI could induce significant changes in humoral immunity characterized by a decrease in IgG and IgM levels and an increase in the complements C3 and C4 levels in comparison with the control group. Moreover, compared with the control group, a significant reduction in peripheral blood CD3+ and CD3+CD4+ lymphocyte counts occurred early (days 1-3) following the onset of trauma. These results provide evidence that TBI is associated with substantial changes in humoral immunity and cellular immunity, which may explain the high incidence of infection encountered in these patients.
journal_name
Ann Clin Lab Scijournal_title
Annals of clinical and laboratory scienceauthors
Wang JW,Li JP,Song YL,Zhao QHsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
10-16issue
1eissn
0091-7370issn
1550-8080pii
47/1/10journal_volume
47pub_type
杂志文章abstract：:The aim of this study was to assess the efficacy and pharmacokinetic profiles of gentamicin, vancomycin, and levofloxacin in a rat air pouch model, in which Staphylococcus aureus (ATCC 25293) was used as the test organism. Antibiotic treatments (i.p.) were started 1 hour after bacterial inoculation and continued for 5...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The pathologic evaluation of hepatic changes secondary to drug ingestion is a difficult task because of the limited histologic response of the liver to hepatotoxins. The majority of these pharmacologic agents produce cholestasis, hepatitis, or both. Some drugs will produce damage if given for a sufficient time and in ...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
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abstract：:The anucleate mature erythrocyte also lacks ribosomes and mitochondria and thus cannot synthesize enzymes or derive energy from the Krebs citric acid cycle. Nevertheless, the red blood cell is metabolically active and contains numerous residual enzymes and their products which are essential for its survival and normal...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
更新日期：1980-09-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2020-09-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
更新日期：1980-03-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2020-11-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:The pattern of excretion of urinary acid mucopolysaccharides (AMPS) has been helpful to establish the diagnosis of mucopolysaccharidoses. The importance of urine analysis for AMPS and the specific enzyme assays is exemplified in a 3 1/2 year old Caucasian male with severe mental retardation, small stature, thoracolumb...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,评审
doi：
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are responsible for a variety of human diseases. Therefore, rapid detection of these viruses in clinical laboratory is important. Recently Aptima Herpes Simplex 1 and 2 assay has been approved by the FDA. We evaluated analytical performance of this assay by com...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 信件
doi：
更新日期：2015-07-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：OBJECTIVE:MiR-15 is involved in modulating many cellular processes that are normally destroyed in disease. The regulation of the cell cycle, angiogenesis, and responses to cellular stress are notable processes influenced by MiR-15. MiR-15 plays a critical role in the model of inflammation-related angiogenesis defects. ...
journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章,meta分析
doi：
更新日期：2018-07-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
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journal_title：Annals of clinical and laboratory science
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
