Preparation of a new composite combining strengthened β-tricalcium phosphate with platelet-rich plasma as a potential scaffold for the repair of bone defects.

abstract：:The present study reports the case of a 33-year-old male who presented with Terson syndrome with no cerebral hemorrhage secondary to traumatic brain injury (TBI). A computed tomography scan of the patient, who had sustained an impact injury to the right occipital region, showed no cerebral lesion. Ophthalmoscopy clear...

journal_title：Experimental and therapeutic medicine

authors： Jing XB,Sun LQ

更新日期：2014-01-01 00:00:00

abstract：:Previous research has shown that breathing exercises may improve the prognosis and health status in patients with lung cancer by enhancing pulmonary function and quality of life (QOL). However, individually published results are inconclusive. The aim of the present meta-analysis was to evaluate the clinical value of b...

journal_title：Experimental and therapeutic medicine

authors： Liu W,Pan YL,Gao CX,Shang Z,Ning LJ,Liu X

更新日期：2013-04-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present stud...

journal_title：Experimental and therapeutic medicine

authors： Qi Y,Zhang C,Zhao S,Huang Y,Yang R

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to characterize the effects of early growth response factor-1 DNA enzyme (EDRz) in a rat abdominal aortic aneurysm (AAA) model to determine the mechanism by which EDRz inhibits AAA and affects the formation of AAA by regulating the activity of matrix metalloproteinase (MMP)-2 and MMP-9...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Dong H,Liu C,Xu G,Hu X,Fan Y,Chen L

更新日期：2018-07-01 00:00:00

abstract：:MicroRNAs (miRs) are have been demonstrated to serve important functions in the genesis of human cancer, including colorectal cancer (CRC). The role of miR-6852 in CRC remains unknown. In this study, it was demonstrated that miR-6852 was underexpressed in CRC tissues compared with adjacent normal tissues. Moreover, th...

journal_title：Experimental and therapeutic medicine

authors： Cui BH,Hong X

更新日期：2018-08-01 00:00:00

abstract：:Alzheimer's disease (AD) brains demonstrate decreased levels of brain-derived neurotrophic factor (BDNF) and increased levels of β-amyloid peptide (Aβ), which is neurotoxic. The present study assessed the impact of BDNF on the toxic effects of Aβ25-35-induced apoptosis and the effects on BDNF-mediated signaling using ...

journal_title：Experimental and therapeutic medicine

authors： Kim JH

更新日期：2014-12-01 00:00:00

abstract：:Matrine is an active component of Leguminosae plants and is thought to exhibit anti-tumor effects. However, the effects of matrine on drug-resistant cancer have not been fully elucidated. The present study aimed to investigate the effects of matrine on vincristine (VCR)-resistant retinoblastoma (RB) cells and to asses...

journal_title：Experimental and therapeutic medicine

authors： Zhao B,Li B,Liu Q,Gao F,Zhang Z,Bai H,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:Ischemic heart disease is a major cause of mortality and disability worldwide. Timely reperfusion is currently the most effective method of treating ischemic heart disease; however, abrupt reperfusion may cause ischemia/reperfusion (I/R) injury. Apoptosis serves an important role in the progression of myocardial I/R i...

journal_title：Experimental and therapeutic medicine

authors： Tan H,Chen L,Ma J

更新日期：2017-11-01 00:00:00

abstract：:The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-m...

journal_title：Experimental and therapeutic medicine

authors： Tangchirakhaphan S,Innajak S,Nilwarangkoon S,Tanjapatkul N,Mahabusrakum W,Watanapokasin R

更新日期：2018-03-01 00:00:00

abstract：:Our study retrospectively investigated the expression of forkhead/winged helix transcription factor (Foxp3) in renal tissue and clinical features of patients with hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN). A total of 58 patients with HBV-GN were assigned to group A; 45 serum and renal tissue HBsAg...

journal_title：Experimental and therapeutic medicine

authors： Zhao W,Ma Y,Wang M,Shi C,Sun J,Chu K,Liu C

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...

journal_title：Experimental and therapeutic medicine

authors： Fu H,Tan J,Yin Q

更新日期：2015-01-01 00:00:00

abstract：:Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision...

journal_title：Experimental and therapeutic medicine

authors： Hua R,Chen K,Hu Y,Wang X,Chen L

更新日期：2015-11-01 00:00:00

abstract：:Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like er...

journal_title：Experimental and therapeutic medicine

authors： Zhang L,Tong C,Tan Y,Peng S,He Y,Wang T

更新日期：2018-09-01 00:00:00

abstract：:Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the ...

journal_title：Experimental and therapeutic medicine

authors： Yuan FY,Zhang MX,Shi YH,Li MH,Ou JY,Bai WF,Zhang MS

更新日期：2020-09-01 00:00:00

abstract：:The aim of this study was to explore the use of urantide as an antagonist of the urotensin II (UII) receptor, G protein-coupled receptor 14 (GPR14), to protect against atherosclerosis (AS) in rats. The AS rat model was induced by an intraperitoneal injection of vitamin D3 (VD3) into rats fed with a high-fat diet for f...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Yu QX,Kong W,Gao HC,Sun B,Xie YQ,Ren LQ

更新日期：2013-06-01 00:00:00

abstract：:In recent years accumulating evidence has indicated that tocotrienol exhibits an oxidation resistance function, decreased cholesterol function, inhibits cancer function and has unique physiological functions, including anti-inflammatory, anti-apoptotic and anti-oxidative properties. The present study investigated the ...

journal_title：Experimental and therapeutic medicine

authors： Xun C,Mamat M,Guo H,Mamati P,Sheng J,Zhang J,Xu T,Liang W,Cao R,Sheng W

更新日期：2017-07-01 00:00:00

abstract：:Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs. Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC). However, oxaliplatin resistance is a major challenge in the treatm...

journal_title：Experimental and therapeutic medicine

authors： Cong X,Liu X,Dong X,Fang S,Sun Z,Fan J

更新日期：2021-02-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis. Tumor tissue and blood samples were obtained from 46 patients with osteosarc...

journal_title：Experimental and therapeutic medicine

authors： Fang Y,Zhang Z,Wang Q,Zhao J

更新日期：2015-06-01 00:00:00

abstract：:Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identificat...

journal_title：Experimental and therapeutic medicine

authors： Pan T,Ji W,Nie M,Li Y

更新日期：2016-11-01 00:00:00

abstract：:The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and va...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Lin B,He Y,Zhang W,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:Abnormalities in insulin hormone levels leads to a hyperglycemic condition of diabetic mellitus. Hyperglycemia seriously induces organ and system destructions. The excessive accumulation of collagen fiber deposits occurs in inflammatory and reorganization processes of chronic liver diseases in type I insulin-dependent...

journal_title：Experimental and therapeutic medicine

authors： Komolkriengkrai M,Nopparat J,Vongvatcharanon U,Anupunpisit V,Khimmaktong W

更新日期：2019-08-01 00:00:00

abstract：:Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phosp...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Hwang I,Kim S,Hong EJ,Jeung EB

更新日期：2013-12-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and o...

journal_title：Experimental and therapeutic medicine

authors： Petralia MC,Mazzon E,Mangano K,Fagone P,Di Marco R,Falzone L,Basile MS,Nicoletti F,Cavalli E

更新日期：2020-03-01 00:00:00

abstract：:Previous studies have demonstrated that autophagy induced by caloric restriction (CR) is neuroprotective against cerebral ischemia. However, it has not been determined whether intermittent fasting (IF), a variation of CR, can exert autophagy-related neuroprotection against cerebral ischemia. Therefore, the neuroprotec...

journal_title：Experimental and therapeutic medicine

authors： Jeong JH,Yu KS,Bak DH,Lee JH,Lee NS,Jeong YG,Kim DK,Kim JJ,Han SY

更新日期：2016-11-01 00:00:00

abstract：:The present study aimed to investigate whether c-mesenchymal epithelial transition factor (C-MET) overexpression combined with RAS (including KRAS, NRAS and HRAS) or BRAF mutations were associated with late distant metastases and the prognosis of patients with colorectal cancer (CRC). A total of 374 patients with stag...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Zeng W,Huang C,Wang J,Xu L,Ma D

更新日期：2018-05-01 00:00:00

abstract：:Glucocorticoids are a class of steroid hormones commonly used for the treatment of hematological malignancies due to their ability to induce apoptosis in lymphoid cells. An understanding of the critical steps in glucocorticoid-induced apoptosis is required to identify sources of drug resistance. Previously, we found t...

journal_title：Experimental and therapeutic medicine

authors： Tome ME,Lee K,Jaramillo MC,Briehl MM

更新日期：2012-02-01 00:00:00