Duodenal-Type Follicular Lymphoma: A Clinicopathologic Review.

Abstract:

:Duodenal-type follicular lymphoma (D-FL) is a newly recognized entity in the 2016 World Health Organization classification update. It has an immunophenotype similar to that of other FLs and usually carries the typical t(14;18)(q32;q21) translocation. However, unlike other FLs, D-FL is almost always diagnosed at a low stage and stays localized to the small intestine, most commonly the second portion of the duodenum, whereas the vast majority of other FLs are diagnosed at an advanced stage. Additionally, D-FL gene expression and pathogenesis appear to be more closely related to extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue than to other types of FL. Therefore, many oncologists have opted to treat this variant of FL in a "watch and wait" manner because of its excellent prognosis and the rarity of D-FL to progress even when no treatments are attempted.

journal_name

Arch Pathol Lab Med

authors

Marks E,Shi Y

doi

10.5858/arpa.2016-0519-RS

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

542-547

issue

4

eissn

0003-9985

issn

1543-2165

journal_volume

142

pub_type

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