Spontaneous hypertrophic cardiomyopathy in a cynomolgus macaque (Macaca fascicularis).

abstract：:Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no...

journal_title：Journal of toxicologic pathology

authors： Kemmochi Y,Ohta T,Motohashi Y,Kaneshige A,Katsumi S,Kakimoto K,Yasui Y,Anagawa-Nakamura A,Toyoda K,Taniai-Riya E,Takahashi A,Shoda T,Yamada T

更新日期：2018-04-01 00:00:00

abstract：:Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...

journal_title：Journal of toxicologic pathology

authors： Fujii E,Kato A,Suzuki M

更新日期：2020-07-01 00:00:00

abstract：:Brain changes associated with risperidone, a dopamine-2/serotonin-2 receptor antagonist, have been documented in rats and humans, but not in nonhuman primates. This study characterized brain changes associated with risperidone in nonhuman primates. Rhesus monkeys were orally administered risperidone in a dose-escalati...

journal_title：Journal of toxicologic pathology

authors： Fernandez G,Kuruvilla S,Hines CDG,Poignant F,Marr J,Forest T,Briscoe R

更新日期：2019-10-01 00:00:00

abstract：:We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...

journal_title：Journal of toxicologic pathology

authors： Hoshikawa Y,Furukawa S,Irie K,Kimura M,Takeuchi K,Sugiyama A

更新日期：2020-10-01 00:00:00

abstract：:Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4....

journal_title：Journal of toxicologic pathology

authors： Chien CC,Yan YH,Juan HT,Cheng TJ,Liao JB,Lee HP,Wang JS

更新日期：2017-10-01 00:00:00

abstract：:A guinea pig (9-week-old) that had been placed in a control group for a pharmacological test was found to have a single nodule on the surface of the right ventricular wall. In a transverse section of the heart after fixation, a whitish mass was found that extended from the subendocardium to the subepicardium of the ri...

journal_title：Journal of toxicologic pathology

authors： Kobayashi T,Kobayashi Y,Fukuda U,Ozeki Y,Takahashi M,Fujioka S,Fuchikami J

更新日期：2010-06-01 00:00:00

abstract：:We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...

journal_title：Journal of toxicologic pathology

authors： Hashimoto S,Doi T,Wako Y,Sato J,Wada S,Tsuchitani M

更新日期：2013-09-01 00:00:00

abstract：:Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...

journal_title：Journal of toxicologic pathology

authors： Yoshizawa K,Emoto Y,Kinoshita Y,Kimura A,Uehara N,Yuri T,Shikata N,Tsubura A

更新日期：2013-03-01 00:00:00

abstract：:Accurate analysis of female reproductive toxicity requires a thorough understanding the differences in and specifics of estrous or menstrual cycles between laboratory animals. There are some species differences such as the time of sex maturation, the length of the estrous or menstrual cycle, the length of the luteal p...

journal_title：Journal of toxicologic pathology

authors： Sato J,Nasu M,Tsuchitani M

更新日期：2016-07-01 00:00:00

abstract：:Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (ERK1/2) signaling pl...

journal_title：Journal of toxicologic pathology

authors： Chen H,Wang Q,Shi D,Yao D,Zhang L,Xiong J,Xu B

更新日期：2016-10-01 00:00:00

abstract：:A single mass was found on the left submandibular salivary gland at necropsy of a 15-month-old male commercially bred laboratory Beagle dog from a control dose group from a repeat toxicity study. Microscopically, the mass was composed of a well-demarcated area of coagulative necrosis surrounded and separated from the ...

journal_title：Journal of toxicologic pathology

authors： Mukaratirwa S,Petterino C,Bradley A

更新日期：2015-07-01 00:00:00

abstract：:Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, th...

journal_title：Journal of toxicologic pathology

authors： Ito T,Katoh Y,Shimada Y,Ohnuma-Koyama A,Takahashi N,Kuwahara M,Harada T

更新日期：2016-01-01 00:00:00

abstract：:Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and ...

journal_title：Journal of toxicologic pathology

authors： Hafez E,Takahashi T,Ogawa H,Sato M,Nakai T,Takasu C,Uehara H,Izumi K

更新日期：2011-12-01 00:00:00

abstract：:The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset w...

journal_title：Journal of toxicologic pathology

authors： Tochitani T,Matsumoto I,Hoshino K,Toyosawa K,Kouchi M,Koujitani T,Kimura J,Funabashi H

更新日期：2013-06-01 00:00:00

abstract：:Chronic lung injury resulting from a variety of different causes is frequently associated with the develop ment of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents pl...

journal_title：Journal of toxicologic pathology

authors： Yoshida T,Ohnuma A,Horiuchi H,Harada T

更新日期：2011-03-01 00:00:00

abstract：:Dysferlin (DYSF) is involved in the membrane-repair process, in the intracellular vesicle system and in T-tubule development in skeletal muscle. It interacts with mitsugumin 53, annexins, caveolin-3, AHNAK, affixin, S100A10, calpain-3, tubulin and dihydropyridine receptor. Limb-girdle muscular dystrophy 2B (LGMD2B) an...

journal_title：Journal of toxicologic pathology

authors： Kobayashi K,Izawa T,Kuwamura M,Yamate J

更新日期：2012-06-01 00:00:00

abstract：:Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...

journal_title：Journal of toxicologic pathology

authors： Fujisawa H,Zhang Z,Sun W,Huang M,Kobayashi J,Yasuda H,Kinoshita Y,Ando R,Tamura K

更新日期：2012-09-01 00:00:00

abstract：:This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...

journal_title：Journal of toxicologic pathology

authors： Watanabe A,Koizumi T,Horikawa T,Sano Y,Uki H,Miyajima K,Kemuriyama N,Anzai R,Iwata H,Anzai T,Nakagawa K,Nakae D

更新日期：2020-04-01 00:00:00

abstract：:Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...

journal_title：Journal of toxicologic pathology

authors： Kato M,Wei M,Yamano S,Fujioka M,Kakehashi A,Wanibuchi H

更新日期：2013-12-01 00:00:00

abstract：:It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...

journal_title：Journal of toxicologic pathology

authors： Tsuchiya Y,Sakai H,Hirata A,Yanai T

更新日期：2018-10-01 00:00:00

abstract：:We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age....

journal_title：Journal of toxicologic pathology

authors： Kodama R,Okazaki T,Sato T,Iwashige S,Tanigawa Y,Fujishima J,Moriyama A,Yamashita N,Sasaki Y,Yoshikawa T,Kamimura Y,Maeda H

更新日期：2012-03-01 00:00:00

abstract：:To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist , male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as...

journal_title：Journal of toxicologic pathology

authors： Nishimura J,Dewa Y,Jin M,Saegusa Y,Kawai M,Kemmochi S,Shimamoto K,Harada T,Itoh T,Shima T,Shibutani M,Mitsumori K

更新日期：2009-12-01 00:00:00

abstract：:An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...

journal_title：Journal of toxicologic pathology

authors： Tanaka N,Izawa T,Yamate J,Kuwamura M

更新日期：2017-07-01 00:00:00

abstract：:Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...

journal_title：Journal of toxicologic pathology

authors： Terayama Y,Kodama Y,Matsuura T,Ozaki K

更新日期：2017-01-01 00:00:00

abstract：:Busulfan, an antineoplastic bifunctional-alkylating agent, is known to induce developmental anomalies. In the present study, we examined the distribution and sequence of pyknotic cells in rat fetal tissues exposed to busulfan. Pregnant rats on gestation day 13 were administered intraperitoneally 30 mg/kg of busulfan, ...

journal_title：Journal of toxicologic pathology

authors： Ohira T,Ando R,Andoh R,Nakazawa T,Nishihara K,Yamamoto S,Nakamura N,Tamura K

更新日期：2009-09-01 00:00:00

abstract：:The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...

journal_title：Journal of toxicologic pathology

authors： Okawa S,Unuma K,Yamada A,Aki T,Uemura K

更新日期：2015-01-01 00:00:00

abstract：:Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports ...

journal_title：Journal of toxicologic pathology

authors： Sonoda J,Seki Y,Hakura A,Hosokawa S

更新日期：2015-04-01 00:00:00

abstract：:The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is invo...

journal_title：Journal of toxicologic pathology

authors： Okumura M,Kato K,Fukui R,Fukushima N,Tsujiuchi T

更新日期：2011-09-01 00:00:00

abstract：:Liposomes have been used as a vehicle for encapsulating chemicals or toxins in toxicological studies. We investigated the transient effects of empty liposomes on hepatic macrophages by applying a single intravenous injection at a dose of 10 ml/kg body weight in 6-week-old male F344 rats. One day after injection, the n...

journal_title：Journal of toxicologic pathology

authors： Pervin M,Golbar HM,Bondoc A,Izawa T,Kuwamura M,Yamate J

更新日期：2016-04-01 00:00:00

abstract：:Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...

journal_title：Journal of toxicologic pathology

authors： Yoshida M,Inoue K,Takahashi M

更新日期：2015-10-01 00:00:00