Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling.

abstract：:Liposomes have been used as a vehicle for encapsulating chemicals or toxins in toxicological studies. We investigated the transient effects of empty liposomes on hepatic macrophages by applying a single intravenous injection at a dose of 10 ml/kg body weight in 6-week-old male F344 rats. One day after injection, the n...

journal_title：Journal of toxicologic pathology

authors： Pervin M,Golbar HM,Bondoc A,Izawa T,Kuwamura M,Yamate J

更新日期：2016-04-01 00:00:00

abstract：:Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...

journal_title：Journal of toxicologic pathology

authors： Yoshida M,Inoue K,Takahashi M

更新日期：2015-10-01 00:00:00

abstract：:Intratracheal instillation is the introduction of a substance directly into the trachea. Intratracheal instillation has been used to investigate the lung toxicity of several chemicals and requires the suspension or dissolution of test material in a vehicle for even dispersal throughout the lung. Importantly, the toxic...

journal_title：Journal of toxicologic pathology

authors： Numano T,Morioka M,Higuchi H,Uda K,Sugiyama T,Hagiwara T,Doi Y,Imai N,Kawabe M,Mera Y,Tamano S

更新日期：2020-01-01 00:00:00

abstract：:To prevent fixation defects or artifacts in the whole bodies of fish caused by conventional fixatives, such as formalin solution, Bouin's fluid (BF), and Davidson's fluid (DF), the optimal fixatives and fixing method were examined. An improved method of fixing the whole bodies of fish was examined that makes use of a ...

journal_title：Journal of toxicologic pathology

authors： Miki M,Ohishi N,Nakamura E,Furumi A,Mizuhashi F

更新日期：2018-07-01 00:00:00

abstract：:Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...

journal_title：Journal of toxicologic pathology

authors： Lee YH,Seo DS,Lee MJ,Cha HG

更新日期：2019-10-01 00:00:00

abstract：:The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset w...

journal_title：Journal of toxicologic pathology

authors： Tochitani T,Matsumoto I,Hoshino K,Toyosawa K,Kouchi M,Koujitani T,Kimura J,Funabashi H

更新日期：2013-06-01 00:00:00

abstract：:Brain changes associated with risperidone, a dopamine-2/serotonin-2 receptor antagonist, have been documented in rats and humans, but not in nonhuman primates. This study characterized brain changes associated with risperidone in nonhuman primates. Rhesus monkeys were orally administered risperidone in a dose-escalati...

journal_title：Journal of toxicologic pathology

authors： Fernandez G,Kuruvilla S,Hines CDG,Poignant F,Marr J,Forest T,Briscoe R

更新日期：2019-10-01 00:00:00

abstract：:Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...

journal_title：Journal of toxicologic pathology

authors： Yoshizawa K,Emoto Y,Kinoshita Y,Kimura A,Uehara N,Yuri T,Shikata N,Tsubura A

更新日期：2013-03-01 00:00:00

abstract：:We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...

journal_title：Journal of toxicologic pathology

authors： Hashimoto S,Doi T,Wako Y,Sato J,Wada S,Tsuchitani M

更新日期：2013-09-01 00:00:00

abstract：:This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...

journal_title：Journal of toxicologic pathology

authors： Watanabe A,Koizumi T,Horikawa T,Sano Y,Uki H,Miyajima K,Kemuriyama N,Anzai R,Iwata H,Anzai T,Nakagawa K,Nakae D

更新日期：2020-04-01 00:00:00

abstract：:The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...

journal_title：Journal of toxicologic pathology

authors： Brändli-Baiocco A,Balme E,Bruder M,Chandra S,Hellmann J,Hoenerhoff MJ,Kambara T,Landes C,Lenz B,Mense M,Rittinghausen S,Satoh H,Schorsch F,Seeliger F,Tanaka T,Tsuchitani M,Wojcinski Z,Rosol TJ

更新日期：2018-01-01 00:00:00

abstract：:We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...

journal_title：Journal of toxicologic pathology

authors： Hoshikawa Y,Furukawa S,Irie K,Kimura M,Takeuchi K,Sugiyama A

更新日期：2020-10-01 00:00:00

abstract：:Busulfan, an antineoplastic bifunctional-alkylating agent, is known to induce developmental anomalies. In the present study, we examined the distribution and sequence of pyknotic cells in rat fetal tissues exposed to busulfan. Pregnant rats on gestation day 13 were administered intraperitoneally 30 mg/kg of busulfan, ...

journal_title：Journal of toxicologic pathology

authors： Ohira T,Ando R,Andoh R,Nakazawa T,Nishihara K,Yamamoto S,Nakamura N,Tamura K

更新日期：2009-09-01 00:00:00

abstract：:The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that...

journal_title：Journal of toxicologic pathology

authors： Shiraki K,Ono M,Kajikawa S,Takeuchi A,Murakami Y,Oishi Y,Matsumoto M

更新日期：2012-12-01 00:00:00

abstract：:The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...

journal_title：Journal of toxicologic pathology

authors： Dong N,Li Z,Li Q,Wu J,Jia P,Wang Y,Gao Z,Han G,Wu Y,Zhou J,Shan J,Li H,Wei W

更新日期：2014-04-01 00:00:00

abstract：:An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...

journal_title：Journal of toxicologic pathology

authors： Tanaka N,Izawa T,Yamate J,Kuwamura M

更新日期：2017-07-01 00:00:00

abstract：:The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...

journal_title：Journal of toxicologic pathology

authors： Fukui M,Fukui N,Sakai K,Hasegawa Y,Nagasaki S,Shibata S,Araki S,Isobe M,Hisada S

更新日期：2013-12-01 00:00:00

abstract：:A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, w...

journal_title：Journal of toxicologic pathology

authors： Tada Y,Yano N,Takahashi H,Yuzawa K,Ando H,Kubo Y,Nagasawa A,Chin K,Kawamata Y,Sakai R,Ohashi N,Ogata A,Nakae D

更新日期：2010-03-01 00:00:00

abstract：:Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...

journal_title：Journal of toxicologic pathology

authors： Kato M,Wei M,Yamano S,Fujioka M,Kakehashi A,Wanibuchi H

更新日期：2013-12-01 00:00:00

abstract：:We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age....

journal_title：Journal of toxicologic pathology

authors： Kodama R,Okazaki T,Sato T,Iwashige S,Tanigawa Y,Fujishima J,Moriyama A,Yamashita N,Sasaki Y,Yoshikawa T,Kamimura Y,Maeda H

更新日期：2012-03-01 00:00:00

abstract：:It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...

journal_title：Journal of toxicologic pathology

authors： Tsuchiya Y,Sakai H,Hirata A,Yanai T

更新日期：2018-10-01 00:00:00

abstract：:Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...

journal_title：Journal of toxicologic pathology

authors： Fujii E,Kato A,Suzuki M

更新日期：2020-07-01 00:00:00

abstract：:Accurate analysis of female reproductive toxicity requires a thorough understanding the differences in and specifics of estrous or menstrual cycles between laboratory animals. There are some species differences such as the time of sex maturation, the length of the estrous or menstrual cycle, the length of the luteal p...

journal_title：Journal of toxicologic pathology

authors： Sato J,Nasu M,Tsuchitani M

更新日期：2016-07-01 00:00:00

abstract：:The term cardiomyopathy is used to describe heart disease resulting from an abnormality in the myocardium. It is rare in cynomolgus macaques (Macaca fascicularis). Here, we report a case of hypertrophic cardiomyopathy in an 11-year-old male cynomolgus macaque. Macroscopically, the interventricular septum (IVS) and the...

journal_title：Journal of toxicologic pathology

authors： Konishi S,Kotera T,Koga M,Ueda M

更新日期：2018-01-01 00:00:00

abstract：:Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...

journal_title：Journal of toxicologic pathology

authors： Fujisawa H,Zhang Z,Sun W,Huang M,Kobayashi J,Yasuda H,Kinoshita Y,Ando R,Tamura K

更新日期：2012-09-01 00:00:00

abstract：:Dysferlin (DYSF) is involved in the membrane-repair process, in the intracellular vesicle system and in T-tubule development in skeletal muscle. It interacts with mitsugumin 53, annexins, caveolin-3, AHNAK, affixin, S100A10, calpain-3, tubulin and dihydropyridine receptor. Limb-girdle muscular dystrophy 2B (LGMD2B) an...

journal_title：Journal of toxicologic pathology

authors： Kobayashi K,Izawa T,Kuwamura M,Yamate J

更新日期：2012-06-01 00:00:00

abstract：:The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is invo...

journal_title：Journal of toxicologic pathology

authors： Okumura M,Kato K,Fukui R,Fukushima N,Tsujiuchi T

更新日期：2011-09-01 00:00:00

abstract：:Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...

journal_title：Journal of toxicologic pathology

authors： Terayama Y,Kodama Y,Matsuura T,Ozaki K

更新日期：2017-01-01 00:00:00

abstract：:Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in re...

journal_title：Journal of toxicologic pathology

authors： Seely JC

更新日期：2017-04-01 00:00:00

abstract：:Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports ...

journal_title：Journal of toxicologic pathology

authors： Sonoda J,Seki Y,Hakura A,Hosokawa S

更新日期：2015-04-01 00:00:00