Abstract:
:The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is involved in cell migration of mouse lung tumor cells stimulated by TPA. Exogenous LPA(3) gene (Lpar3)-expressing (LL/2-a3) cells and LL/2-AB cells as a vector control generated from LL/2 cells were used. In a cell migration assay, TPA treatment significantly stimulated cell migration of LL/2-AB and LL/2-a3 cells, while the cell migration abilities of LL/2-a3 were markedly lower than those of LL/2-AB cells. Using quantitative real-time reverse transcription (RT)-polymerase chain reaction (PCR) analysis, no effect of TPA treatment on the expression levels of LPA(1), LPA(2) and LPA(3) genes was detected in either type of cells. These results suggest that the LPA(3) may not be involved in the enhanced migration ability by TPA in mouse lung tumor cells.
journal_name
J Toxicol Patholjournal_title
Journal of toxicologic pathologyauthors
Okumura M,Kato K,Fukui R,Fukushima N,Tsujiuchi Tdoi
10.1293/tox.24.183subject
Has Abstractpub_date
2011-09-01 00:00:00pages
183-6issue
3eissn
0914-9198issn
1881-915Xpii
0599journal_volume
24pub_type
杂志文章abstract::We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.26.275
更新日期:2013-09-01 00:00:00
abstract::The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2013-0049
更新日期:2014-04-01 00:00:00
abstract::Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0049
更新日期:2019-10-01 00:00:00
abstract::The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1293/tox.31.1S
更新日期:2018-01-01 00:00:00
abstract::We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2020-0033
更新日期:2020-10-01 00:00:00
abstract::Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2014-0061
更新日期:2015-04-01 00:00:00
abstract::Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, th...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2015-0046
更新日期:2016-01-01 00:00:00
abstract::The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type nonclinical toxicology studies. Trainees optimally should undertake a scientific curriculum of at least 5 years at an accredited...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.23.171
更新日期:2010-09-01 00:00:00
abstract::Accurate analysis of female reproductive toxicity requires a thorough understanding the differences in and specifics of estrous or menstrual cycles between laboratory animals. There are some species differences such as the time of sex maturation, the length of the estrous or menstrual cycle, the length of the luteal p...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1293/tox.2016-0021
更新日期:2016-07-01 00:00:00
abstract::Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (ERK1/2) signaling pl...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2016-0032
更新日期:2016-10-01 00:00:00
abstract::Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2015-0026
更新日期:2015-10-01 00:00:00
abstract::A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, w...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.23.39
更新日期:2010-03-01 00:00:00
abstract::An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2017-0004
更新日期:2017-07-01 00:00:00
abstract::Chronic lung injury resulting from a variety of different causes is frequently associated with the develop ment of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents pl...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.9
更新日期:2011-03-01 00:00:00
abstract::Busulfan, an antineoplastic bifunctional-alkylating agent, is known to induce developmental anomalies. In the present study, we examined the distribution and sequence of pyknotic cells in rat fetal tissues exposed to busulfan. Pregnant rats on gestation day 13 were administered intraperitoneally 30 mg/kg of busulfan, ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.22.167
更新日期:2009-09-01 00:00:00
abstract::Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2013-0039
更新日期:2013-12-01 00:00:00
abstract::To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist , male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.22.255
更新日期:2009-12-01 00:00:00
abstract::The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2013-0012
更新日期:2013-12-01 00:00:00
abstract::Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2016-0035
更新日期:2017-01-01 00:00:00
abstract::The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset w...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.26.187
更新日期:2013-06-01 00:00:00
abstract::Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4....
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2017-0025
更新日期:2017-10-01 00:00:00
abstract::Intratracheal instillation is the introduction of a substance directly into the trachea. Intratracheal instillation has been used to investigate the lung toxicity of several chemicals and requires the suspension or dissolution of test material in a vehicle for even dispersal throughout the lung. Importantly, the toxic...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0060
更新日期:2020-01-01 00:00:00
abstract::Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1293/tox.2020-0007
更新日期:2020-07-01 00:00:00
abstract::Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of majo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.113
更新日期:2011-06-01 00:00:00
abstract::The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2014-0053
更新日期:2015-01-01 00:00:00
abstract::This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0086
更新日期:2020-04-01 00:00:00
abstract::Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.25.215
更新日期:2012-09-01 00:00:00
abstract::Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2017-0064
更新日期:2018-04-01 00:00:00
abstract::Endogenous prostaglandin (PG) E(2) plays important roles in renal homeostasis. Immunoexpressions of PGE(2) biosynthesis-related enzymes, cyclooxygenase (COX)-2 and microsomal PGE(2) synthetase (mPGES)-1 and EP4 (a PGE(2) receptor), were investigated in renal development. Kidney tissues were obtained from fetuses on ge...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.257
更新日期:2011-12-01 00:00:00
abstract::A single mass was found on the left submandibular salivary gland at necropsy of a 15-month-old male commercially bred laboratory Beagle dog from a control dose group from a repeat toxicity study. Microscopically, the mass was composed of a well-demarcated area of coagulative necrosis surrounded and separated from the ...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2015-0018
更新日期:2015-07-01 00:00:00