Sustained renal inflammation following 2 weeks of inhalation of occupationally relevant levels of zinc oxide nanoparticles in Sprague Dawley rats.

abstract：:The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...

journal_title：Journal of toxicologic pathology

authors： Fukui M,Fukui N,Sakai K,Hasegawa Y,Nagasaki S,Shibata S,Araki S,Isobe M,Hisada S

更新日期：2013-12-01 00:00:00

abstract：:Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...

journal_title：Journal of toxicologic pathology

authors： Kato M,Wei M,Yamano S,Fujioka M,Kakehashi A,Wanibuchi H

更新日期：2013-12-01 00:00:00

abstract：:Brain changes associated with risperidone, a dopamine-2/serotonin-2 receptor antagonist, have been documented in rats and humans, but not in nonhuman primates. This study characterized brain changes associated with risperidone in nonhuman primates. Rhesus monkeys were orally administered risperidone in a dose-escalati...

journal_title：Journal of toxicologic pathology

authors： Fernandez G,Kuruvilla S,Hines CDG,Poignant F,Marr J,Forest T,Briscoe R

更新日期：2019-10-01 00:00:00

abstract：:We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...

journal_title：Journal of toxicologic pathology

authors： Hoshikawa Y,Furukawa S,Irie K,Kimura M,Takeuchi K,Sugiyama A

更新日期：2020-10-01 00:00:00

abstract：:The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...

journal_title：Journal of toxicologic pathology

authors： Dong N,Li Z,Li Q,Wu J,Jia P,Wang Y,Gao Z,Han G,Wu Y,Zhou J,Shan J,Li H,Wei W

更新日期：2014-04-01 00:00:00

abstract：:A single mass was found on the left submandibular salivary gland at necropsy of a 15-month-old male commercially bred laboratory Beagle dog from a control dose group from a repeat toxicity study. Microscopically, the mass was composed of a well-demarcated area of coagulative necrosis surrounded and separated from the ...

journal_title：Journal of toxicologic pathology

authors： Mukaratirwa S,Petterino C,Bradley A

更新日期：2015-07-01 00:00:00

abstract：:The common marmoset (Callithrix jacchus) is now widely used in various research fields, including toxicology. However, information about the background pathology of this species is scarce. Here, we report a case of rhabdomyosarcoma that spontaneously occurred in a common marmoset. A 44-month-old male common marmoset w...

journal_title：Journal of toxicologic pathology

authors： Tochitani T,Matsumoto I,Hoshino K,Toyosawa K,Kouchi M,Koujitani T,Kimura J,Funabashi H

更新日期：2013-06-01 00:00:00

abstract：:A guinea pig (9-week-old) that had been placed in a control group for a pharmacological test was found to have a single nodule on the surface of the right ventricular wall. In a transverse section of the heart after fixation, a whitish mass was found that extended from the subendocardium to the subepicardium of the ri...

journal_title：Journal of toxicologic pathology

authors： Kobayashi T,Kobayashi Y,Fukuda U,Ozeki Y,Takahashi M,Fujioka S,Fuchikami J

更新日期：2010-06-01 00:00:00

abstract：:The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...

journal_title：Journal of toxicologic pathology

authors： Okawa S,Unuma K,Yamada A,Aki T,Uemura K

更新日期：2015-01-01 00:00:00

abstract：:To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist , male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as...

journal_title：Journal of toxicologic pathology

authors： Nishimura J,Dewa Y,Jin M,Saegusa Y,Kawai M,Kemmochi S,Shimamoto K,Harada T,Itoh T,Shima T,Shibutani M,Mitsumori K

更新日期：2009-12-01 00:00:00

abstract：:Endogenous prostaglandin (PG) E(2) plays important roles in renal homeostasis. Immunoexpressions of PGE(2) biosynthesis-related enzymes, cyclooxygenase (COX)-2 and microsomal PGE(2) synthetase (mPGES)-1 and EP4 (a PGE(2) receptor), were investigated in renal development. Kidney tissues were obtained from fetuses on ge...

journal_title：Journal of toxicologic pathology

authors： Yamamoto E,Izawa T,Kuwamura M,Yamate J

更新日期：2011-12-01 00:00:00

abstract：:Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of majo...

journal_title：Journal of toxicologic pathology

authors： Weber K,Mowat V,Hartmann E,Razinger T,Chevalier HJ,Blumbach K,Green OP,Kaiser S,Corney S,Jackson A,Casadesus A

更新日期：2011-06-01 00:00:00

abstract：:Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...

journal_title：Journal of toxicologic pathology

authors： Yoshizawa K,Emoto Y,Kinoshita Y,Kimura A,Uehara N,Yuri T,Shikata N,Tsubura A

更新日期：2013-03-01 00:00:00

abstract：:Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in re...

journal_title：Journal of toxicologic pathology

authors： Seely JC

更新日期：2017-04-01 00:00:00

abstract：:Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no...

journal_title：Journal of toxicologic pathology

authors： Kemmochi Y,Ohta T,Motohashi Y,Kaneshige A,Katsumi S,Kakimoto K,Yasui Y,Anagawa-Nakamura A,Toyoda K,Taniai-Riya E,Takahashi A,Shoda T,Yamada T

更新日期：2018-04-01 00:00:00

abstract：:The term cardiomyopathy is used to describe heart disease resulting from an abnormality in the myocardium. It is rare in cynomolgus macaques (Macaca fascicularis). Here, we report a case of hypertrophic cardiomyopathy in an 11-year-old male cynomolgus macaque. Macroscopically, the interventricular septum (IVS) and the...

journal_title：Journal of toxicologic pathology

authors： Konishi S,Kotera T,Koga M,Ueda M

更新日期：2018-01-01 00:00:00

abstract：:Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and ...

journal_title：Journal of toxicologic pathology

authors： Hafez E,Takahashi T,Ogawa H,Sato M,Nakai T,Takasu C,Uehara H,Izumi K

更新日期：2011-12-01 00:00:00

abstract：:Busulfan, an antineoplastic bifunctional-alkylating agent, is known to induce developmental anomalies. In the present study, we examined the distribution and sequence of pyknotic cells in rat fetal tissues exposed to busulfan. Pregnant rats on gestation day 13 were administered intraperitoneally 30 mg/kg of busulfan, ...

journal_title：Journal of toxicologic pathology

authors： Ohira T,Ando R,Andoh R,Nakazawa T,Nishihara K,Yamamoto S,Nakamura N,Tamura K

更新日期：2009-09-01 00:00:00

abstract：:It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...

journal_title：Journal of toxicologic pathology

authors： Tsuchiya Y,Sakai H,Hirata A,Yanai T

更新日期：2018-10-01 00:00:00

abstract：:Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, th...

journal_title：Journal of toxicologic pathology

authors： Ito T,Katoh Y,Shimada Y,Ohnuma-Koyama A,Takahashi N,Kuwahara M,Harada T

更新日期：2016-01-01 00:00:00

abstract：:Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...

journal_title：Journal of toxicologic pathology

authors： Fujii E,Kato A,Suzuki M

更新日期：2020-07-01 00:00:00

abstract：:Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...

journal_title：Journal of toxicologic pathology

authors： Yoshida M,Inoue K,Takahashi M

更新日期：2015-10-01 00:00:00

abstract：:Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...

journal_title：Journal of toxicologic pathology

authors： Terayama Y,Kodama Y,Matsuura T,Ozaki K

更新日期：2017-01-01 00:00:00

abstract：:Intratracheal instillation is the introduction of a substance directly into the trachea. Intratracheal instillation has been used to investigate the lung toxicity of several chemicals and requires the suspension or dissolution of test material in a vehicle for even dispersal throughout the lung. Importantly, the toxic...

journal_title：Journal of toxicologic pathology

authors： Numano T,Morioka M,Higuchi H,Uda K,Sugiyama T,Hagiwara T,Doi Y,Imai N,Kawabe M,Mera Y,Tamano S

更新日期：2020-01-01 00:00:00

abstract：:The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is invo...

journal_title：Journal of toxicologic pathology

authors： Okumura M,Kato K,Fukui R,Fukushima N,Tsujiuchi T

更新日期：2011-09-01 00:00:00

abstract：:Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated...

journal_title：Journal of toxicologic pathology

authors： Suzuki T,Kado S,Ando M,Nagata Y,Iwata S,Kobayashi T,Uchida K

更新日期：2009-03-01 00:00:00

abstract：:We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...

journal_title：Journal of toxicologic pathology

authors： Hashimoto S,Doi T,Wako Y,Sato J,Wada S,Tsuchitani M

更新日期：2013-09-01 00:00:00

abstract：:The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type nonclinical toxicology studies. Trainees optimally should undertake a scientific curriculum of at least 5 years at an accredited...

journal_title：Journal of toxicologic pathology

authors： Bolon B,Barale-Thomas E,Bradley A,Ettlin RA,Franchi CA,George C,Giusti AM,Hall R,Jacobsen M,Konishi Y,Ledieu D,Morton D,Park JH,Scudamore CL,Tsuda H,Vijayasarathi SK,Wijnands MV

更新日期：2010-09-01 00:00:00

abstract：:Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...

journal_title：Journal of toxicologic pathology

authors： Lee YH,Seo DS,Lee MJ,Cha HG

更新日期：2019-10-01 00:00:00

abstract：:The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...

journal_title：Journal of toxicologic pathology

authors： Brändli-Baiocco A,Balme E,Bruder M,Chandra S,Hellmann J,Hoenerhoff MJ,Kambara T,Landes C,Lenz B,Mense M,Rittinghausen S,Satoh H,Schorsch F,Seeliger F,Tanaka T,Tsuchitani M,Wojcinski Z,Rosol TJ

更新日期：2018-01-01 00:00:00