A cardiac rhabdomyoma in a Guinea pig.

abstract：:Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...

journal_title：Journal of toxicologic pathology

authors： Yoshizawa K,Emoto Y,Kinoshita Y,Kimura A,Uehara N,Yuri T,Shikata N,Tsubura A

更新日期：2013-03-01 00:00:00

abstract：:Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and ...

journal_title：Journal of toxicologic pathology

authors： Hafez E,Takahashi T,Ogawa H,Sato M,Nakai T,Takasu C,Uehara H,Izumi K

更新日期：2011-12-01 00:00:00

abstract：:Dysferlin (DYSF) is involved in the membrane-repair process, in the intracellular vesicle system and in T-tubule development in skeletal muscle. It interacts with mitsugumin 53, annexins, caveolin-3, AHNAK, affixin, S100A10, calpain-3, tubulin and dihydropyridine receptor. Limb-girdle muscular dystrophy 2B (LGMD2B) an...

journal_title：Journal of toxicologic pathology

authors： Kobayashi K,Izawa T,Kuwamura M,Yamate J

更新日期：2012-06-01 00:00:00

abstract：:Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (ERK1/2) signaling pl...

journal_title：Journal of toxicologic pathology

authors： Chen H,Wang Q,Shi D,Yao D,Zhang L,Xiong J,Xu B

更新日期：2016-10-01 00:00:00

abstract：:Busulfan, an antineoplastic bifunctional-alkylating agent, is known to induce developmental anomalies. In the present study, we examined the distribution and sequence of pyknotic cells in rat fetal tissues exposed to busulfan. Pregnant rats on gestation day 13 were administered intraperitoneally 30 mg/kg of busulfan, ...

journal_title：Journal of toxicologic pathology

authors： Ohira T,Ando R,Andoh R,Nakazawa T,Nishihara K,Yamamoto S,Nakamura N,Tamura K

更新日期：2009-09-01 00:00:00

abstract：:An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...

journal_title：Journal of toxicologic pathology

authors： Tanaka N,Izawa T,Yamate J,Kuwamura M

更新日期：2017-07-01 00:00:00

abstract：:Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...

journal_title：Journal of toxicologic pathology

authors： Fujisawa H,Zhang Z,Sun W,Huang M,Kobayashi J,Yasuda H,Kinoshita Y,Ando R,Tamura K

更新日期：2012-09-01 00:00:00

abstract：:Accurate analysis of female reproductive toxicity requires a thorough understanding the differences in and specifics of estrous or menstrual cycles between laboratory animals. There are some species differences such as the time of sex maturation, the length of the estrous or menstrual cycle, the length of the luteal p...

journal_title：Journal of toxicologic pathology

authors： Sato J,Nasu M,Tsuchitani M

更新日期：2016-07-01 00:00:00

abstract：:The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...

journal_title：Journal of toxicologic pathology

authors： Brändli-Baiocco A,Balme E,Bruder M,Chandra S,Hellmann J,Hoenerhoff MJ,Kambara T,Landes C,Lenz B,Mense M,Rittinghausen S,Satoh H,Schorsch F,Seeliger F,Tanaka T,Tsuchitani M,Wojcinski Z,Rosol TJ

更新日期：2018-01-01 00:00:00

abstract：:Sarcopenia is the age-related decrease of muscle mass and function. Diabetes and obesity are known to be risk factors that exacerbate sarcopenia, but the underlying mechanism of diabetes-related sarcopenia is still unknown. Obese type 2 diabetes SDT fatty rats show early onset of severe diabetes and there have been no...

journal_title：Journal of toxicologic pathology

authors： Kemmochi Y,Ohta T,Motohashi Y,Kaneshige A,Katsumi S,Kakimoto K,Yasui Y,Anagawa-Nakamura A,Toyoda K,Taniai-Riya E,Takahashi A,Shoda T,Yamada T

更新日期：2018-04-01 00:00:00

abstract：:It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...

journal_title：Journal of toxicologic pathology

authors： Tsuchiya Y,Sakai H,Hirata A,Yanai T

更新日期：2018-10-01 00:00:00

abstract：:To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist , male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as...

journal_title：Journal of toxicologic pathology

authors： Nishimura J,Dewa Y,Jin M,Saegusa Y,Kawai M,Kemmochi S,Shimamoto K,Harada T,Itoh T,Shima T,Shibutani M,Mitsumori K

更新日期：2009-12-01 00:00:00

abstract：:Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cig...

journal_title：Journal of toxicologic pathology

authors： Kato M,Wei M,Yamano S,Fujioka M,Kakehashi A,Wanibuchi H

更新日期：2013-12-01 00:00:00

abstract：:This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...

journal_title：Journal of toxicologic pathology

authors： Watanabe A,Koizumi T,Horikawa T,Sano Y,Uki H,Miyajima K,Kemuriyama N,Anzai R,Iwata H,Anzai T,Nakagawa K,Nakae D

更新日期：2020-04-01 00:00:00

abstract：:We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age....

journal_title：Journal of toxicologic pathology

authors： Kodama R,Okazaki T,Sato T,Iwashige S,Tanigawa Y,Fujishima J,Moriyama A,Yamashita N,Sasaki Y,Yoshikawa T,Kamimura Y,Maeda H

更新日期：2012-03-01 00:00:00

abstract：:A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, w...

journal_title：Journal of toxicologic pathology

authors： Tada Y,Yano N,Takahashi H,Yuzawa K,Ando H,Kubo Y,Nagasawa A,Chin K,Kawamata Y,Sakai R,Ohashi N,Ogata A,Nakae D

更新日期：2010-03-01 00:00:00

abstract：:Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F1 mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports ...

journal_title：Journal of toxicologic pathology

authors： Sonoda J,Seki Y,Hakura A,Hosokawa S

更新日期：2015-04-01 00:00:00

abstract：:Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...

journal_title：Journal of toxicologic pathology

authors： Lee YH,Seo DS,Lee MJ,Cha HG

更新日期：2019-10-01 00:00:00

abstract：:The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...

journal_title：Journal of toxicologic pathology

authors： Dong N,Li Z,Li Q,Wu J,Jia P,Wang Y,Gao Z,Han G,Wu Y,Zhou J,Shan J,Li H,Wei W

更新日期：2014-04-01 00:00:00

abstract：:Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, th...

journal_title：Journal of toxicologic pathology

authors： Ito T,Katoh Y,Shimada Y,Ohnuma-Koyama A,Takahashi N,Kuwahara M,Harada T

更新日期：2016-01-01 00:00:00

abstract：:Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of majo...

journal_title：Journal of toxicologic pathology

authors： Weber K,Mowat V,Hartmann E,Razinger T,Chevalier HJ,Blumbach K,Green OP,Kaiser S,Corney S,Jackson A,Casadesus A

更新日期：2011-06-01 00:00:00

abstract：:To prevent fixation defects or artifacts in the whole bodies of fish caused by conventional fixatives, such as formalin solution, Bouin's fluid (BF), and Davidson's fluid (DF), the optimal fixatives and fixing method were examined. An improved method of fixing the whole bodies of fish was examined that makes use of a ...

journal_title：Journal of toxicologic pathology

authors： Miki M,Ohishi N,Nakamura E,Furumi A,Mizuhashi F

更新日期：2018-07-01 00:00:00

abstract：:The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...

journal_title：Journal of toxicologic pathology

authors： Okawa S,Unuma K,Yamada A,Aki T,Uemura K

更新日期：2015-01-01 00:00:00

abstract：:Brain changes associated with risperidone, a dopamine-2/serotonin-2 receptor antagonist, have been documented in rats and humans, but not in nonhuman primates. This study characterized brain changes associated with risperidone in nonhuman primates. Rhesus monkeys were orally administered risperidone in a dose-escalati...

journal_title：Journal of toxicologic pathology

authors： Fernandez G,Kuruvilla S,Hines CDG,Poignant F,Marr J,Forest T,Briscoe R

更新日期：2019-10-01 00:00:00

abstract：:Alloxan (AL) is a material well-known to induce diabetes. Prior to inducing a prolonged diabetic state, AL causes acute tubulointerstitial nephritis. However, the precise primary target site and mechanism of its nephrotoxicity remain unclear. The objective of this study was to evaluate the morphological characteristic...

journal_title：Journal of toxicologic pathology

authors： Terayama Y,Kodama Y,Matsuura T,Ozaki K

更新日期：2017-01-01 00:00:00

abstract：:Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated...

journal_title：Journal of toxicologic pathology

authors： Suzuki T,Kado S,Ando M,Nagata Y,Iwata S,Kobayashi T,Uchida K

更新日期：2009-03-01 00:00:00

abstract：:Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4....

journal_title：Journal of toxicologic pathology

authors： Chien CC,Yan YH,Juan HT,Cheng TJ,Liao JB,Lee HP,Wang JS

更新日期：2017-10-01 00:00:00

abstract：:The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...

journal_title：Journal of toxicologic pathology

authors： Fukui M,Fukui N,Sakai K,Hasegawa Y,Nagasaki S,Shibata S,Araki S,Isobe M,Hisada S

更新日期：2013-12-01 00:00:00

abstract：:The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that...

journal_title：Journal of toxicologic pathology

authors： Shiraki K,Ono M,Kajikawa S,Takeuchi A,Murakami Y,Oishi Y,Matsumoto M

更新日期：2012-12-01 00:00:00

abstract：:We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...

journal_title：Journal of toxicologic pathology

authors： Hashimoto S,Doi T,Wako Y,Sato J,Wada S,Tsuchitani M

更新日期：2013-09-01 00:00:00