Abstract:
:Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, the tumor showed the following four growth patterns: a solid pattern of polygonal cells embedded in an osteoid eosinophilic matrix with calcification, an irregular sheet pattern of short spindle cells accompanying some eosinophilic multinucleated cells, a fascicular pattern of spindle cells and a cystic pattern lined by short spindle cells. Immunohistochemically, most of the tumor cells were positive for vimentin, proliferating cell nuclear antigen and osterix. The multinucleated cells mentioned above were desmin positive and were regarded as regenerative striated muscles but not tumor cells. Since no clear continuity with normal bone tissues was observed, the tumor was diagnosed as an "extraskeletal osteosarcoma."
journal_name
J Toxicol Patholjournal_title
Journal of toxicologic pathologyauthors
Ito T,Katoh Y,Shimada Y,Ohnuma-Koyama A,Takahashi N,Kuwahara M,Harada Tdoi
10.1293/tox.2015-0046subject
Has Abstractpub_date
2016-01-01 00:00:00pages
39-43issue
1eissn
0914-9198issn
1881-915Xpii
2015-0046journal_volume
29pub_type
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