Abstract:
:Chronic lung injury resulting from a variety of different causes is frequently associated with the develop ment of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents play an etiologic role in the pathogenesis of this disease. The agents discussed in this review include beryllium, nylon flock, textile printing aerosols, polyvinyl chloride and didecyldimethylammonium chloride. The authors also describe a variety of animal models, including genetically modified mice, in order to investigate the molecular mechanism of pulmonary fibrosis, focusing on chemokine receptors, regulatory T cells and transforming growth factor-β and bone morphogenetic protein signaling. Overall, we propose the concept of toxicological pulmonary fibrosis as a lung disease induced in response to environmental cues.
journal_name
J Toxicol Patholjournal_title
Journal of toxicologic pathologyauthors
Yoshida T,Ohnuma A,Horiuchi H,Harada Tdoi
10.1293/tox.24.9subject
Has Abstractpub_date
2011-03-01 00:00:00pages
9-24issue
1eissn
0914-9198issn
1881-915Xpii
0401journal_volume
24pub_type
杂志文章abstract::The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internatio...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1293/tox.31.1S
更新日期:2018-01-01 00:00:00
abstract::Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.22.83
更新日期:2009-03-01 00:00:00
abstract::Intratracheal instillation is the introduction of a substance directly into the trachea. Intratracheal instillation has been used to investigate the lung toxicity of several chemicals and requires the suspension or dissolution of test material in a vehicle for even dispersal throughout the lung. Importantly, the toxic...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0060
更新日期:2020-01-01 00:00:00
abstract::A single mass was found on the left submandibular salivary gland at necropsy of a 15-month-old male commercially bred laboratory Beagle dog from a control dose group from a repeat toxicity study. Microscopically, the mass was composed of a well-demarcated area of coagulative necrosis surrounded and separated from the ...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2015-0018
更新日期:2015-07-01 00:00:00
abstract::Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4....
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2017-0025
更新日期:2017-10-01 00:00:00
abstract::Diabetes mellitus (DM) and obesity are believed to be risk factors for colorectal cancer in humans. In experiment 1, male nondiabetic Long-Evans Tokushima Otsuka (LETO) rats and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 DM, were whole-body X-irradiated (4 Gy) at 6 and 8 weeks of age and ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.187
更新日期:2011-12-01 00:00:00
abstract::Morphological and immunohistochemical examinations were carried out on the pancreas of a hyperglycemic 5-year-old male cynomolgus monkey. Body weight gradually decreased from 6 months before termination, accompanying a slight reduction in food consumption and anorexia for the last 2 days. The blood glucose level was m...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.25.215
更新日期:2012-09-01 00:00:00
abstract::The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistoch...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2013-0049
更新日期:2014-04-01 00:00:00
abstract::The present report describes a rare case of spontaneous hemangiosarcoma in a nine-week-old male Sprague-Dawley rat. At necropsy, multiple white nodules of various sizes were observed on and within the enlarged spleen and liver and were histopathologically determined to be composed of spindle- to oval-shaped cells that...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.25.273
更新日期:2012-12-01 00:00:00
abstract::To clarify the modifying effect of N-Acetyl-L-Cysteine (NAC), which has antioxidative ability, on hepatocarcinogenesis promoted by fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR) alpha agonist , male F344/N rats were administered a single intraperitoneal injection of N-diethylnitrosamine (DEN) as...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.22.255
更新日期:2009-12-01 00:00:00
abstract::Many variables may affect the outcome of continuous infusion studies. The results largely depend on the experience of the laboratory performing these studies, the technical equipment used, the choice of blood vessels and hence the surgical technique as well the quality of pathological evaluation. The latter is of majo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.113
更新日期:2011-06-01 00:00:00
abstract::Tumor research has largely relied on xenograft models created by the engraftment of cultured cell lines derived from tumor tissues into immunodeficient mice for in vivo studies. Like in vitro models, such models retain the ability of tumor cells to continuously proliferate, so they have been used to predict the clinic...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章,评审
doi:10.1293/tox.2020-0007
更新日期:2020-07-01 00:00:00
abstract::We performed a medaka bioassay for the carcinogenicity of methylazoxymethaol acetate (MAM-Ac) to examine the sequential histological changes in the liver from 3 days after exposure until tumor development. The medaka were exposed to MAM-Ac at a concentration of 2 ppm for 24 hours, and were necropsied at 3, 7, 10, 14, ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2020-0033
更新日期:2020-10-01 00:00:00
abstract::We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHan(TM):WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.26.275
更新日期:2013-09-01 00:00:00
abstract::Numerous pieces of evidence have revealed that oxaliplatin (OXA) evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome side effects needs to be further investigated. It is well known that cyclooxygenase-2 (COX-2) and extracellular signal-regulated kinases (ERK1/2) signaling pl...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2016-0032
更新日期:2016-10-01 00:00:00
abstract::Uterine deciduomas were found in two female virgin rats, a 15-week-old Lewis rat and a 7-week-old Sprague-Dawley rat. The firm white nodules were located at the base of unilateral uterine horns and were approximately 6 mm and 4 mm in diameter. Histopathologically, the nodules were composed of three areas, each with a ...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.26.61
更新日期:2013-03-01 00:00:00
abstract::The involvement of the lung during the septic systemic inflammatory response elicited by administration of lipopolysaccharide (LPS) was investigated. Eight-week-old male Sprague-Dawley rats were injected i.p. with 15 mg/kg LPS. After 24 h, the lungs were excised to evaluate the cellular responses to LPS. Matrix-assist...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2014-0053
更新日期:2015-01-01 00:00:00
abstract::We investigated chronological changes in immunohistochemical phenotyping in the thymus and spleen in Crl:CD rats up to the age of about one year. In the thymus, T cells increased markedly from 3 to 4 weeks of age. Proliferating cells also increased markedly at these points. B cells tended towards an increase with age....
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.25.55
更新日期:2012-03-01 00:00:00
abstract::A subchronic feeding study of l-serine (l-Ser) was conducted with groups of 10 male and 10 female Fischer 344 rats fed a powder diet containing 0, 0.06, 0.5, 1.5 or 5.0% concentrations of l-Ser for 90 days. There were no toxicologically significant, treatment-related changes with regards to body weight, food intake, w...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.23.39
更新日期:2010-03-01 00:00:00
abstract::Polyhexamethylene guanidine hydrochloride (PHMG-HCl), an antimicrobial additive in humidifier disinfectants, was associated with the pulmonary disease outbreak in South Korea. However, PHMG-mediated oxidative stress has only been studied in vitro. Here, we evaluated PHMG-induced oxidative stress in the lungs of rats e...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0049
更新日期:2019-10-01 00:00:00
abstract::Dysferlin (DYSF) is involved in the membrane-repair process, in the intracellular vesicle system and in T-tubule development in skeletal muscle. It interacts with mitsugumin 53, annexins, caveolin-3, AHNAK, affixin, S100A10, calpain-3, tubulin and dihydropyridine receptor. Limb-girdle muscular dystrophy 2B (LGMD2B) an...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.25.135
更新日期:2012-06-01 00:00:00
abstract::The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type nonclinical toxicology studies. Trainees optimally should undertake a scientific curriculum of at least 5 years at an accredited...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.23.171
更新日期:2010-09-01 00:00:00
abstract::The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. Recently, we reported that loss of lysophosphatidic acid (LPA) receptor-3 (LPA(3)) enhanced cell migration of murine lung tumor LL/2 cells. In the present study, we investigated whether LPA(3) is invo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.24.183
更新日期:2011-09-01 00:00:00
abstract::The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in t...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2013-0012
更新日期:2013-12-01 00:00:00
abstract::It is well known that fasting substantially affects the metabolism of drugs and chemicals. Food restriction also affects drug kinetics, such as absorption, metabolism, and excretion, and therefore, it can potentially modulate the onset of chemical toxicity or drug-induced adverse reactions. In the present study, the e...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2018-0009
更新日期:2018-10-01 00:00:00
abstract::Endometrial adenocarcinoma in the uterine corpus is a malignant cancer that occurs in menopausal women and aged rodents. Because of the similarities in pathogenesis and morphology of endometrial adenocarcinoma in rodents and humans, prediction of the modes of action (MOA) in uterine carcinogenesis is important for ext...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2015-0026
更新日期:2015-10-01 00:00:00
abstract::The term cardiomyopathy is used to describe heart disease resulting from an abnormality in the myocardium. It is rare in cynomolgus macaques (Macaca fascicularis). Here, we report a case of hypertrophic cardiomyopathy in an 11-year-old male cynomolgus macaque. Macroscopically, the interventricular septum (IVS) and the...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2017-0027
更新日期:2018-01-01 00:00:00
abstract::An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. In the fibrous connective tissue surrounding the nes...
journal_title:Journal of toxicologic pathology
pub_type:
doi:10.1293/tox.2017-0004
更新日期:2017-07-01 00:00:00
abstract::Liposomes have been used as a vehicle for encapsulating chemicals or toxins in toxicological studies. We investigated the transient effects of empty liposomes on hepatic macrophages by applying a single intravenous injection at a dose of 10 ml/kg body weight in 6-week-old male F344 rats. One day after injection, the n...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2015-0082
更新日期:2016-04-01 00:00:00
abstract::This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial ligation of the renal arteries (RL). Separate groups of 10-week-old male Slc:Sprague-Dawley rats underwent RL and were fed diets with varying phosphorous levels fo...
journal_title:Journal of toxicologic pathology
pub_type: 杂志文章
doi:10.1293/tox.2019-0086
更新日期:2020-04-01 00:00:00