Abstract:
BACKGROUND:Chronic rhinosinusitis (CRS) is a common illness, yet little is known about its pathogenesis, including the role played by respiratory viruses. METHODS:A transversal prospective study was conducted to analyze the seasonality of CRS using real-time polymerase chain reaction to detect respiratory virus genomes in secretions and tissue samples from patients with CRS with and without nasal polyps. RESULTS:The frequency of viral detection was 41% (31/75). The respiratory virus most frequently detected was human rhinovirus, found in 18 patients (24%), followed by human metapneumovirus, human enterovirus, human respiratory sincicial virus, human adenovirus, human bocavirus, human coronavirus, and human influenza virus, detected in 12 (16%), five (6.6%), four (5.3%), four (5.3%), two (2.6%), two (2.6%), and one (1.3%) patient(s), respectively. Although none of the patients presented symptoms when the samples were collected, there was a peak in detection of the most prevalent virus in the autumn and winter seasons of both years, similar to the pattern that occurs in acute conditions. CONCLUSIONS:The pattern of respiratory virus seasonality found in nasal mucosa, polyps, and paranasal sinus samples in patients with CRS reinforces the possibility of asymptomatic respiratory viral infections.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Lima JT,Paula FE,Proença-Modena JL,Demarco RC,Buzatto GP,Saturno TH,Delcaro LS,Tamashiro E,Valera FC,Arruda E,Anselmo-Lima WTdoi
10.2500/ajra.2015.29.4129subject
Has Abstractpub_date
2015-01-01 00:00:00pages
19-22issue
1eissn
1945-8924issn
1945-8932journal_volume
29pub_type
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