Abstract:
BACKGROUND:The purpose of this study was to investigate the expression and distribution of superoxide anion, NADPH oxidase (NOX)1, and NOX4 in healthy, allergic nasal mucosa and nasal polyps to evaluate the possible influence of oxidative stress on the development of allergic rhinitis and nasal polyps. METHODS:The expression and distribution of superoxide anion, NOX1 and NOX4 were evaluated in healthy and allergic nasal mucosa and nasal polyps, using dihydroethidium fluorescence, semiquantitative reverse transcriptase-polymerase chain reaction, immunohistochemistry, and Western blot. RESULTS:NOX1 and NOX4 were localized mainly in the epithelial layer, submucosal glands, vascular endothelium, and inflammatory cells in healthy and allergic nasal mucosa and nasal polyps. The cellular source that generated superoxide anion is also localized in the epithelial cells, submucosal glands, vascular endothelium, and inflammatory cells, demonstrating the similar sites of expression of NOX1 and NOX4 in healthy and allergic nasal mucosa and nasal polyps. NOX1 and NOX4 mRNA and proteins and superoxide anions had increased levels of expression in allergic nasal mucosa and nasal polyps compared with healthy nasal mucosa. CONCLUSIONS:These results indicate that NOX1 and NOX4 may play an important role in reactive oxygen species production, contributing to the oxidative stress in allergic rhinitis and nasal polyp tissues.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Moon JH,Kim TH,Lee HM,Lee SH,Choe W,Kim HK,Lee JH,Oh KH,Lee SHdoi
10.2500/ajra.2009.23.3340subject
Has Abstractpub_date
2009-07-01 00:00:00pages
370-6issue
4eissn
1945-8924issn
1945-8932journal_volume
23pub_type
杂志文章abstract:BACKGROUND:The extent of surgery required in the management of pediatric non-medial subperiosteal orbital abscess (SPOA) due to medically refractory complicated acute sinusitis is unknown. OBJECTIVES:The primary objective is to compare operative outcomes of children treated with combined endoscopic sinus surgery (ESS)...
journal_title:American journal of rhinology & allergy
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abstract:BACKGROUND:Increasingly bacterial biofilms have been implicated in chronic rhinosinusitis (CRS), and conventional treatment methods have failed to completely eradicate biofilms. (1) Terminal sialic acids present on sinus mucosal glycoproteins are targets for bacterial adherence and biofilm formation. (2) A subpopulatio...
journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2013-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2015-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2013-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2014-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2018-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
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更新日期:2013-03-01 00:00:00
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journal_title:American journal of rhinology & allergy
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