Abstract:
BACKGROUND:CD203c is a basophil surface marker and its expression is rapidly up-regulated after cross-linking of high-affinity immunoglobulin E (IgE) receptor (FcepsilonR1) by an allergen. CD203c basophil activation tests have been studied for the in vitro diagnosis of several allergic conditions. However, there is limited data about its diagnostic usefulness. The optimum allergen concentrations for stimulation and allergen specific cutoff values remain unknown for a number of allergens. This study was designed to investigate the efficacy of basophil activation test via CD203c in the diagnosis of pollen allergy. METHODS:The CD203c basophil activation was determined in 31 allergic rhinitis patients with pollen allergy and 9 healthy nonatopic controls during the off-season. CD203c expression was evaluated using three-color staining protocol by flow cytometry. RESULTS:After an in vitro stimulation with grass pollen extract, the CD203c assay clearly discriminated pollen-allergic patients from controls (p < 0.001). A dose-dependent increase in the percentages of CD203c-activated basophils was shown in rhinitis patients with pollen allergy (p < 0.001). The sensitivity and specificity was 100% and optimal cutoff values were 14.05 and 10.05% with 45.1 and 4.5 μg/mL Phl p 5 stimulation, respectively. Although the specificity was also 100%, the sensitivity was 93 and 87% and the cutoff values were 5.40 and 5.35% with 4.5 × 10(-4) and 4.5 × 10(-5) micrograms/mL Phl p 5 stimulation, respectively. CONCLUSION:The CD203c basophil activation test seems to be a reliable tool in the diagnosis of grass pollen allergy. It could be used when conventional diagnostic tests fail or can not be performed.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Özdemir SK,Güloğlu D,Sin BA,Elhan AH,Ikincioğulları A,Mısırlıgil Zdoi
10.2500/ajra.2011.25.3723subject
Has Abstractpub_date
2011-11-01 00:00:00pages
e225-31issue
6eissn
1945-8924issn
1945-8932journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Nasal congestion and/or obstruction represents a prevalent and extensively studied problem. No published research exists that describes the impact of nasal hair (vibrissae) on nasal obstruction. OBJECTIVE:To assess the impact of nasal vibrissae on subjective and objective measurements of nasal obstruction. ...
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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journal_title:American journal of rhinology & allergy
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abstract:BACKGROUND:This study reports the combined experience of the University of Miami and University of Pittsburgh with endoscopic endonasal resection of esthesioneuroblastoma (ENB). A retrospective case series review was performed in a tertiary care university hospital. METHODS:Twenty-three patients, 16 men and 7 women, w...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,多中心研究
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2011-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2016.30.4369
更新日期:2016-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3653
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00