Abstract:
BACKGROUND:This study was designed to determine if the addition of large-volume, low-positive pressure nasal irrigations delivered with isotonic sodium chloride (hereinafter "saline") added to intranasal corticosteroid therapy improves quality of life and objective measures of nasal breathing in patients with allergic rhinitis when compared with intranasal corticosteroid alone. METHODS:A prospective, unblinded, single-arm pilot study was performed of patients with allergic rhinitis already on intranasal corticosteroid pharmacotherapy. Patients added large-volume low-pressure saline irrigation twice daily for 8 weeks to their ongoing regiment of nasal corticosteroid. Mini-Rhinoconjunctivitis Quality of life Questionnaire (mRQLQ) assessment and nasal peak inspiratory flow (NPIF) were performed at baseline and at 4 and 8 weeks. RESULTS:A total of 40 patients were enrolled. Twice-daily nasal irrigation with isotonic saline significantly (p < 0.001) reduced mRQLQ scores, from 36.7 ± 20.48 (baseline) to 14.9 ± 11.03 (4 weeks) to 10.10 ± 10.65 (8 weeks). No significant changes were seen in NPIF, pattern use of nasal steroid use, or adverse events. CONCLUSION:Large-volume, low-positive pressure nasal irrigation with isotonic saline is an effective adjunctive therapy to improve quality of life in patients with allergic rhinitis already on intranasal corticosteroid therapy. This study was a part of the clinical trial NCT01030146 registered at clinicaltrials.gov.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Nguyen SA,Psaltis AJ,Schlosser RJdoi
10.2500/ajra.2014.28.4066subject
Has Abstractpub_date
2014-07-01 00:00:00pages
308-11issue
4eissn
1945-8924issn
1945-8932pii
content-4066journal_volume
28pub_type
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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journal_title:American journal of rhinology & allergy
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pub_type: 杂志文章,随机对照试验
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