Abstract:
BACKGROUND:B-cell responses may play a role in the pathogenesis of nasal polyposis via local IgA and IgE production and activation of eosinophils and mast cells. B-cell attracting chemokines may therefore have relevance in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs) Methods: Polyp and inferior turbinate tissues were obtained from CRSwNPs, CRS without NPs (CRSsNPs), and control patients; ELISA and reverse-transcription polymerase chain reaction were used to detect levels of protein and mRNA for selected B-cell chemokines (B-cell attracting chemokine 1 [CXCL13/BCA-1/BLC]), thymus expressed chemokine (CCL25/TECK), mucosae-associated epithelial chemokine (CCL28/MEC), stromal cell-derived factor-1alpha (CXCL12/SDF-1alpha), and selected chemokine receptor genes (CXCR4, CXCR5, and CXCR7). RESULTS:BCA-1 and SDF-1alpha protein levels were significantly increased in polyp tissue compared with turbinate tissue from CRSsNP patients and controls (p < 0.05 and p < 0.01, respectively). Differences in TECK and MEC were not significant. For mRNA, expression of BCA-1 was significantly up-regulated in polyp tissue and levels correlated with CD20 mRNA expression. Additionally, significant up-regulation of mRNA for the SDF-1alpha receptors CXCR7 and CXCR4 was detected in polyps, while there was a trend for up-regulation of the BCA-1 receptor CXCR5. CONCLUSION:Elevated levels of the BCA-1 and SDF-1alpha and their receptors may account for an increased presence of B cells and their products, contributing to eosinophilic inflammation in patients with CRSwNP.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Patadia M,Dixon J,Conley D,Chandra R,Peters A,Suh LA,Kato A,Carter R,Harris K,Grammer L,Kern R,Schleimer Rdoi
10.2500/ajra.2010.24.3386subject
Has Abstractpub_date
2010-01-01 00:00:00pages
11-6issue
1eissn
1945-8924issn
1945-8932journal_volume
24pub_type
杂志文章abstract:BACKGROUND:The "Candy Smell Test" (CST) has been introduced as a new testing method for the evaluation of the human sense of smell. In contrast to other established orthonasal smell tests, the CST addresses the retronasal application of odors, typical for food aroma effects during mastication and swallowing. The aim of...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3611
更新日期:2011-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418793540
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journal_title:American journal of rhinology & allergy
pub_type: 临床试验,杂志文章
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2017-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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doi:10.2500/ajra.2011.25.3537
更新日期:2011-01-01 00:00:00
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更新日期:2010-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2018.32.4494
更新日期:2018-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
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pub_type: 杂志文章
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420957853
更新日期:2020-09-11 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3764
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:There is a correlation between (18)F-fluorodeoxyglucose (FDG) uptake and the level of intracellular metabolic tumor activity, which in turn may be associated with active proliferation, invasion, and prognosis as well as distant metastases in head and neck cancer. This study was designed to assess whether tum...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3848
更新日期:2013-03-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00