Abstract:
BACKGROUND:Allergic rhinitis (AR), the most common chronic allergic condition in outpatient medicine, is associated with immense health care costs and socioeconomic consequences. AR's impact may be partly from interacting of respiratory conditions via allergic inflammation. This study was designed to review potential interactive mechanisms of AR and associated conditions and consider the relevance of a bidirectional "unified airway" respiratory inflammation model on diagnosis and treatment of inflammatory airway disease. METHODS:MEDLINE was searched for pathophysiology and pathophysiological and epidemiologic links between AR and diseases of the sinuses, lungs, middle ear, and nasopharynx. RESULTS:Allergic-related inflammatory responses or neural and systemic processes fostering inflammatory changes distant from initial allergen provocation may link AR and comorbidities. Treating AR may benefit associated respiratory tract comorbidities. Besides improving AR outcomes, treatment inhibiting eosinophil recruitment and migration, normalizing cytokine profiles, and reducing asthma-associated health care use in atopic subjects would likely ameliorate other upper airway diseases such as acute rhinosinusitis, chronic rhinosinusitis (CRS) with nasal polyposis (NP), adenoidal hypertrophy, and otitis media with effusion. CONCLUSION:Epidemiological concordance of AR with several airway diseases conforms to a bidirectional "unified airway" respiratory inflammation model based on anatomic and histological upper and lower airway connections. Epidemiology and current understanding of inflammatory, humoral, and neural processes make links between AR and disorders including asthma, otitis media, NP, and CRS plausible. Combining AR with associated conditions increases disease burden; worsened associated illness may accompany worsened AR. AR pharmacotherapies include antihistamines, leukotriene antagonists, intranasal corticosteroids, and immunotherapy; treatments attenuating proinflammatory responses may also benefit associated conditions.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Marple BFdoi
10.2500/ajra.2010.24.3499subject
Has Abstractpub_date
2010-07-01 00:00:00pages
249-54issue
4eissn
1945-8924issn
1945-8932journal_volume
24pub_type
杂志文章,评审abstract:BACKGROUND:Upper airway epithelial cells produce bactericidal nitric oxide (NO) in response to both gram-positive and gram-negative bacteria. Our previous work demonstrated that T2R38, a bitter taste receptor (T2R) expressed in airway epithelium, produces NO in response to quorum-sensing molecules secreted by Pseudomon...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4453
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:This study reports the combined experience of the University of Miami and University of Pittsburgh with endoscopic endonasal resection of esthesioneuroblastoma (ENB). A retrospective case series review was performed in a tertiary care university hospital. METHODS:Twenty-three patients, 16 men and 7 women, w...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,多中心研究
doi:10.2500/ajra.2009.23.3269
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Standardized allergen-specific immunotherapy (SIT) has been used in China for years. However, there is no extensive study of the safety of standardized SIT in Chinese patients until now. The aim of the current study is to perform a prospective and multicenter study to evaluate the systemic reactions (SRs) of...
journal_title:American journal of rhinology & allergy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2500/ajra.2014.28.4005
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Specific antibody deficiency may predispose patients to recurrent respiratory tract infections. There is limited literature assessing specific antibody deficiency in chronic rhinosinusitis (CRS). This study evaluated the role of specific antibody deficiency in patients with CRS who have failed medical therap...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3653
更新日期:2011-07-01 00:00:00
abstract::Background Since the Food and Drug Administration approval of balloon sinuplasty (BSP) in 2005, no nationally representative population-based studies have examined the outcomes and adverse events of BSP. Objective To assess the rates of complications and revision surgery in patients who received BSP, functional endosc...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418782248
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Endoscopic sinus surgery (ESS) is a safe and reliable procedure for the treatment of chronic rhinosinusitis (CRS) and nasal polyposis (NP). Although most cases of CRS with NP occur bilaterally, we occasionally encounter patients with unilateral sinus disease with NP. Because no study has been conducted on th...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3482
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:One of the major causes of olfactory disturbances is chronic rhinosinusitis (CRS), and the main surgical modality to treat CRS is functional endoscopic sinus surgery (FESS). It, therefore, is essential to assess the effect of this surgery on olfaction. Also, it is necessary to find new ways of measuring olfa...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2015.29.4207
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:A 10- to 15-mm L-strut in the dorsal and caudal areas of the nasal septum is preserved during septoplasty to maintain structural stability and prevent external deformity. However, during endoscopically performed septoplasty the surgeon has a very different perspective, which may create a more challenging sit...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2014.28.4042
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Post-viral olfactory dysfunction is a common cause of both short- and long-term smell alteration. The coronavirus pandemic further highlights the importance of post-viral olfactory dysfunction. Currently, a comprehensive review of the neural mechanism underpinning post-viral olfactory dysfunction is lacking....
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420957853
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is recognized as a common disease that imposes a big burden on the health system worldwide. There is ongoing evidence of the anti-inflammatory effect of long-term macrolide in the management of patients with CRS. OBJECTIVE:The aim of this randomized clinical trial was to evaluat...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2015.29.4244
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Gelsolin is an actin-binding protein with multiple cellular functions including apoptosis and is reported to be down-regulated in various cancers and premalignant lesions. The objective of this study was to identify gelsolin and caspase-3 expression in inverted papilloma (IP) and investigate the role of gels...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3753
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Fibrinolytic components, their receptors, and inhibitors are considered to play an important role in inflammation and tissue remodeling including chronic rhinosinusitis (CRS). To clarify the relationship between these components and the pathology of CRS, we analyzed fibrinolytic components in sinonasal mucos...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3537
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) has a multifactorial etiology, with a debate about the role of inhalant allergy in the pathogenesis of CRS. OBJECTIVE:This study assessed the impact of allergy status on externalized paranasal sinuses after tumor resection to determine if a predisposition to inhalant allergy bro...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4388
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Recent years have witnessed significant expansion in office-based rhinology. This study assesses practice patterns of the American Rhinologic Society (ARS) membership regarding office-based rhinologic procedures. METHODS:A 24-item survey was disseminated to the ARS membership from March 15 to May 31, 2016. ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418804904
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Antibiotics are frequently used to treat acute rhinosinusitis (ARS; acute sinusitis), although many episodes are viral. Because of community resistance concerns, current evidence provides limited support for the use of antibiotics in ARS. We conducted a retrospective comparative effectiveness outcomes asses...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3781
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a su...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2015.29.4148
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Inadvertent intracranial injury from nasogastric tube (NGT) placement is a described and potentially fatal complication following endoscopic transsphenoidal hypophysectomy (TSH). This cadaver study assessed the role of middle turbinate (MT) preservation and medialization in preventing accidental skull base i...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420933173
更新日期:2021-01-01 00:00:00
abstract::Nasal obstruction is one of the most common presenting symptoms requiring medical attention at both the primary care physician and the otorhinolaryngologists' level. Nasal obstruction may be caused by anatomic, physiological, or neurologic factors. Complexity is added to this situation because, often, the causation ma...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2013.27.3889
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Local allergic rhinitis (LAR) has been observed in patients without atopy. However, LAR is still underdiagnosed in patients with perennial or seasonal nasal symptoms. OBJECTIVE:The aim of this study was to determine the prevalence of LAR in young patients with a previous diagnosis of nonallergic rhinitis or...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2016.30.4369
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The prevalence of rhinitis has been reported to be higher in urban areas. OBJECTIVE:To determine the prevalence of rhinitis in schoolchildren who lived on two islands in the Brazilian Amazon, including a rural island and an urban island, and to identify the associated risk factors. METHODS:Four hundred chi...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2016.30.4293
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Multiple methods exist for nasal septoplasty. Proliferation of endoscopic technology has broadened these options. METHODS:Technical description of two techniques for endoscopic septoplasty. RESULTS:The endoscope can be utilized for visualization under the flaps after, a Killian or hemitransfixion incision,...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4436
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Smoking status has been established as a known irritant of the upper and lower respiratory tracts, leading to inflammation throughout the respiratory system. Tobacco smoking is one comorbidity encountered among chronic rhinosinusitis (CRS) patients. The histopathologic features of CRS and comorbid smoking st...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420929270
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the expression and distribution of superoxide anion, NADPH oxidase (NOX)1, and NOX4 in healthy, allergic nasal mucosa and nasal polyps to evaluate the possible influence of oxidative stress on the development of allergic rhinitis and nasal polyps. METHODS:The exp...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3340
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Internal nasal valve collapse is a preventable complication of rhinoplasty, for which the spreader graft is the gold standard. More recently, the spreader flap technique has been espoused as an alternative to spreader grafting. Here, we evaluated the efficacy of this technique in a randomized trial setting. ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2014.28.3991
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Endoscopic skull base surgery (ESBS) provides a safe, minimally invasive approach to treat benign and malignant skull base lesions. The significance of concomitant sinonasal pathology on imaging in patients undergoing ESBS and its effect on perioperative management is not well described. We sought to ident...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420949130
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Patients report nasal congestion as the most bothersome seasonal allergic rhinitis (SAR) symptom. Measurement of this symptom in previous research has largely been based on subjective patient ratings. This study was designed to measure efficacy, onset, and duration of action of the corticosteroid mometasone ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2010.24.3548
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Nasal packing is usually performed to control bleeding after endoscopic sinus surgery (ESS). Although new packing materials have been developed, they still cause pain. This study was designed to evaluate the effect of lidocaine-soaked packs on pain after ESS. METHODS:A prospective, randomized, double-blind ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2013.27.3942
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:B-cell responses may play a role in the pathogenesis of nasal polyposis via local IgA and IgE production and activation of eosinophils and mast cells. B-cell attracting chemokines may therefore have relevance in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs) Methods: Polyp and inferio...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3386
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:This study was designed to determine whether there is any correlation between results of the skin-prick test and the severity of symptoms in allergic rhinitis. METHODS:We retrospectively evaluated 150 patients with persistent or intermittent allergic rhinitis confirmed by positive skin tests and scaled fro...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3750
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Major histocompatibility complex (MHC) class II is involved in T-cell activation, cytokine secretion, and induction of immune responses. Cytokines, staphylococcus super antigens, and eosinophil activation are proposed to play important roles in aspirin-exacerbated respiratory disease (AERD). OBJECTIVES:This...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2015.29.4154
更新日期:2015-05-01 00:00:00