Abstract：
BACKGROUND:This study reports the combined experience of the University of Miami and University of Pittsburgh with endoscopic endonasal resection of esthesioneuroblastoma (ENB). A retrospective case series review was performed in a tertiary care university hospital. METHODS:Twenty-three patients, 16 men and 7 women, were reviewed. Mean age was 56.6 years (15-79 years). Nineteen patients received primary endoscopic endonasal anterior skull base resection. Of these, the modified Kadish stage at presentation was A in 2 patients, B in 11 patients, C in 5 patients, and D in 1 patient. Three patients had revision surgeries for recurrent tumors. The main outcome measures were complete resection and margin assessment, short-term and long-term complications, and recurrence rate. RESULTS:Complete resection and negative intraoperative resection margins were achieved endoscopically in 17 of the primarily treated cases. The two other cases had one patient that required an additional craniotomy approach to complete the resection of a positive lateral dual margin, another patient had positive margins at the orbital apex. All patients tolerated the endoscopic procedure very well with no meningitis. There were four cerebral spinal fluid leaks. Mean follow-up period for the primarily treated cases was 45.2 months (11-152 months), all were disease free at the most recent available follow-up. CONCLUSION:In experienced hands and carefully selected patients, endoscopic resection of ENB respects the principles of oncologic surgery, providing an adequate exposure for margin assessment as well as reliable reconstruction of the anterior skull defect with a relatively low morbidity.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Folbe A,Herzallah I,Duvvuri U,Bublik M,Sargi Z,Snyderman CH,Carrau R,Casiano R,Kassam AB,Morcos JJdoi
10.2500/ajra.2009.23.3269subject
Has Abstractpub_date
2009-01-01 00:00:00pages
91-4issue
1eissn
1945-8924issn
1945-8932journal_volume
23pub_type
杂志文章,多中心研究abstract：BACKGROUND:Sex hormones are known to have some influence on nasal functions, but their effect on the decongestive response of the nasal mucosa during menstrual cycle is still undetermined. OBJECTIVES:The aim of this study was to examine the nasal physiology, the interconnectedness of olfactory and respiratory nasal fu...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892421990308
更新日期：2021-01-26 00:00:00
abstract：BACKGROUND:Nasal septal deviation (NSD) is a very common deformity. Because it may induce chronic upper airway obstruction in the nose, clinicians encounter some patients who have concerns about whether this can be a risk factor for general health. However, the influence of NSD on general health has rarely been studied...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2016.30.4277
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:Inadvertent intracranial injury from nasogastric tube (NGT) placement is a described and potentially fatal complication following endoscopic transsphenoidal hypophysectomy (TSH). This cadaver study assessed the role of middle turbinate (MT) preservation and medialization in preventing accidental skull base i...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892420933173
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:The pterygopalatine fossa (PPF) can be entered endoscopically, but the endoscopic landmarks to localize the bony structures in the PPF are not well described. This study aimed to investigate the anatomy of the sphenopalatine foramen (SPF), vidian canal (VC), and foramen rotundum (FR) with regard to an endosc...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3638
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:One of the major causes of olfactory disturbances is chronic rhinosinusitis (CRS), and the main surgical modality to treat CRS is functional endoscopic sinus surgery (FESS). It, therefore, is essential to assess the effect of this surgery on olfaction. Also, it is necessary to find new ways of measuring olfa...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2015.29.4207
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established. OBJECTIVE:To determine whether OD and GD are independentl...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892418824451
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Silastic splints have been used as effective tools for septal support, avoiding adhesion, and mucosal healing after septal surgery. Furthermore, although many surgeons insert septal splints, no well-designed trials exist to support their use. A randomized double-blinded controlled trial was performed. METHO...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,随机对照试验
doi：10.2500/ajra.2011.25.3584
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Ginseng (Panax ginseng C.A. Meyer) has been used in Asian countries for the treatment of various diseases. However, the mechanisms of liquid Panax ginseng (LG) on allergic inflammatory response in epidermal growth factor (EGF)-stimulated human airway epithelial cells remain largely unclear. METHODS:MUC5AC, ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3586
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:It is not fully understood how sinonasal epithelial cells detect the presence of pathogens and activate innate defense responses necessary for protecting the upper airway from infection. One mechanism is through bitter taste receptors (T2Rs), which are expressed in the sinonasal cavity. One T2R isoform, T2R3...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2014.28.4077
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:CD203c is a basophil surface marker and its expression is rapidly up-regulated after cross-linking of high-affinity immunoglobulin E (IgE) receptor (FcepsilonR1) by an allergen. CD203c basophil activation tests have been studied for the in vitro diagnosis of several allergic conditions. However, there is li...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3723
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Fibrin glue has been a favorable hydrogel in cartilage tissue engineering, but implantation of chondrocyte-fibrin suspensions have resulted in volume loss. In this study, human septal cartilage chips were seeded onto a fibrin scaffold, and cellular proliferation and production of cartilaginous extracellular ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2009.23.3347
更新日期：2009-09-01 00:00:00
abstract：:Background The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective To develop novel...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.1177/1945892418768159
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The prevalence of rhinitis has been reported to be higher in urban areas. OBJECTIVE:To determine the prevalence of rhinitis in schoolchildren who lived on two islands in the Brazilian Amazon, including a rural island and an urban island, and to identify the associated risk factors. METHODS:Four hundred chi...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2016.30.4293
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:The current otolaryngologic literature is lacking in basic science investigation regarding endoscopic anterior ethmoid artery (AEA) ligation as part of the armamentarium for epistaxis control. This investigation provides the anatomic rationale for endoscopic ligation of the AEA in the surgical treatment of e...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2009.23.3295
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Allergic rhinitis (AR), the most common chronic allergic condition in outpatient medicine, is associated with immense health care costs and socioeconomic consequences. AR's impact may be partly from interacting of respiratory conditions via allergic inflammation. This study was designed to review potential i...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2010.24.3499
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Nasal obstruction (NO) is a very common symptom, but its effect on nasal physiology has not been fully understood. We performed this study to determine the effect of severity of NO due to inferior turbinate hypertrophy on airflow pattern using the computational fluid dynamics simulations. METHODS:A three-di...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2009.23.3287
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Upper airway epithelial cells produce bactericidal nitric oxide (NO) in response to both gram-positive and gram-negative bacteria. Our previous work demonstrated that T2R38, a bitter taste receptor (T2R) expressed in airway epithelium, produces NO in response to quorum-sensing molecules secreted by Pseudomon...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2017.31.4453
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Viral respiratory tract infections are associated with a significant burden of disease and represent one of the leading causes of mortality worldwide. The current Coronavirus Disease 2019 (COVID-19) pandemic highlights the devastating toll that respiratory viruses have on humanity and the desperate need to u...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.1177/1945892420947929
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Standardized allergen-specific immunotherapy (SIT) has been used in China for years. However, there is no extensive study of the safety of standardized SIT in Chinese patients until now. The aim of the current study is to perform a prospective and multicenter study to evaluate the systemic reactions (SRs) of...
journal_title：American journal of rhinology & allergy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.2500/ajra.2014.28.4005
更新日期：2014-01-01 00:00:00
abstract：:Rhinitis is characterized by one or more of the following nasal symptoms: congestion, rhinorrhea (anterior and posterior), sneezing, and itching. It is classified as allergic or nonallergic, the latter being a diverse syndrome that is characterized by symptoms of rhinitis that are not the result of IgE-mediated events...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2013.27.3927
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:The available olfactory evaluation tests are mainly subjective methods requiring patients' collaboration. If, for any reason, the patients refuse to honestly report what they perceive, the test reliability will be questionable; this condition is potentially observable in malingering patients because of thei...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2012.26.3812
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Epiphora has a significant impact on the patient's quality of life and is commonly caused by nasolacrimal duct obstruction. Dacryocystorhinostomy (DCR) has traditionally been performed via an external approach, which involves a skin incision. With the advent of endoscopes, the endonasal approach to DCR has g...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2018.32.4494
更新日期：2018-01-01 00:00:00
abstract：:Nasal obstruction is one of the most common presenting symptoms requiring medical attention at both the primary care physician and the otorhinolaryngologists' level. Nasal obstruction may be caused by anatomic, physiological, or neurologic factors. Complexity is added to this situation because, often, the causation ma...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2013.27.3889
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Topical nasal sprays are commonly prescribed for sinonasal disease. Nasal drops applied in a head-down position are described alternatively to sprays. Multiple research methods have investigated the deposition pattern of intranasal medications, each with limitations. This pilot study analyzed the use of a co...
journal_title：American journal of rhinology & allergy
pub_type： 临床试验,杂志文章
doi：10.2500/ajra.2011.25.3569
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Cigarette smoke exposure (CSE) results in extensive inflammation in the upper and lower airways. Reactive oxygen species, such as superoxide, have been shown to be potent mediators of this inflammation. METHODS:Mucosal biopsy specimens were collected from patients undergoing sinonasal surgery and were used ...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2009.23.3400
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Gelsolin is an actin-binding protein with multiple cellular functions including apoptosis and is reported to be down-regulated in various cancers and premalignant lesions. The objective of this study was to identify gelsolin and caspase-3 expression in inverted papilloma (IP) and investigate the role of gels...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2012.26.3753
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:We prospectively evaluated the efficacy of hyaluronic acid (HA) as an adjuvant treatment to hasten the improvement of nasal respiration and to minimize patients' discomfort in the postoperative radiofrequency volumetric tissue reduction (RFVTR) of inferior turbinates. METHODS:We enrolled 57 patients randoml...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,随机对照试验
doi：10.2500/ajra.2013.27.3869
更新日期：2013-05-01 00:00:00
abstract：:Surgery for chronic rhinosinusitis is an effective complement to a well-designed medical regimen. Functional endoscopic sinus surgery is among the most common surgeries performed for sinonasal disease refractory to maximal medical therapy. Nasal surgery techniques, such as septoplasty and inferior turbinate surgery, m...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,评审
doi：10.2500/ajra.2013.27.3897
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Biofilm formation has been implicated as an etiologic factor in the development of chronic rhinosinusitis (CRS). Nasal irrigation with surfactants including dilute baby shampoo have been proposed as an antibiofilm treatment for CRS patients. The effect of dilute baby shampoo on normal sinonasal mucosal funct...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章
doi：10.2500/ajra.2011.25.3583
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Concerns over radiation exposure with paranasal sinus computed tomography (CT) have recently evolved. Magnetic resonance imaging (MRI) may be more advantageous in this regard, but the diagnostic assessment of MRI in chronic rhinosinusitis (CRS) has not been reported. The purpose of this study was to determin...
journal_title：American journal of rhinology & allergy
pub_type： 杂志文章,随机对照试验
doi：10.2500/ajra.2009.23.3260
更新日期：2009-01-01 00:00:00
