Abstract:
BACKGROUND:Topical nasal sprays are commonly prescribed for sinonasal disease. Nasal drops applied in a head-down position are described alternatively to sprays. Multiple research methods have investigated the deposition pattern of intranasal medications, each with limitations. This pilot study analyzed the use of a conebeam computed tomography (CBCT) scanner to study deposition patterns of intranasal sprays and drops using radiopaque contrast solution. METHODS:Nine volunteers participated in this two-trial study. In trial 1, participants instilled 3 sprays of contrast into each nostril. After 3 minutes a CBCT scan was performed. In trial 2, 3 drops of contrast were instilled into the participants' nostrils in the "vertex-to-floor" position. Again, after 3 minutes a CBCT scan was performed. Two otolaryngologists and a neuroradiologist reviewed the images and scored 21 sites within the sinonasal cavity for the presence of contrast. RESULTS:Contrast was detected in the nasal vestibule and inferior nasal vault in nearly every trial with the spray and drops. Nasal spray was more diffusely distributed within the nasal cavity and was detected at a greater proportion on the floor of the nose, inferior meatus, anterior inferior nasal cavity, and nasopharynx. Neither spray nor drops were consistently detected in spaces superior to the middle turbinate. CONCLUSION:Radiopaque contrast delivered by nasal spray and drops were detected by the CBCT scanner, with a significant difference at one subsite. Neither spray nor drops were detected in superior nasal spaces. The CBCT scan provides an alternative to conventional CT scans in future studies using this technique.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Rudman KL,O'Brien EK,Leopold DAdoi
10.2500/ajra.2011.25.3569subject
Has Abstractpub_date
2011-03-01 00:00:00pages
94-7issue
2eissn
1945-8924issn
1945-8932journal_volume
25pub_type
临床试验,杂志文章abstract:INTRODUCTION:Accountable care organizations (ACO) and alternative payment models are a sign of the change in reimbursement from fee-for-service to value-based reimbursement. The focus of health care under ACOs is represented by the Triple Aim: to improve the experience of health care, improve the health of populations,...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2016.30.4348
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:This study was designed to determine if the addition of large-volume, low-positive pressure nasal irrigations delivered with isotonic sodium chloride (hereinafter "saline") added to intranasal corticosteroid therapy improves quality of life and objective measures of nasal breathing in patients with allergic ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3941
更新日期:2013-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3322
更新日期:2009-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3394
更新日期:2010-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2011.25.3584
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Chronic rhinitis impacts 60 million Americans and is associated with significant costs for patients. Although medical treatments are first line, some patients require surgical intervention such as vidian or posterial nasal neurectomy. Previous reviews have investigated the role of surgical management in chro...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418800879
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:Activation of adenosine monophosphate-activated protein kinase (AMPK) by metformin, as a master regulator of metabolism, is involved in airway tissue remodeling. Here, we investigated the physical role of AMPK on cell migration, matrix contraction, and the production of matrix metalloproteinases (MMP) in nasal ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4477
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Eosinophilic nasal mucosal infiltration is characteristic of nasal polyposis. The aim of this work was to study the possibility of correlations between cytological and tissue eos...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3549
更新日期:2010-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3753
更新日期:2012-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3413
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Nasal packing is usually performed to control bleeding after endoscopic sinus surgery (ESS). Although new packing materials have been developed, they still cause pain. This study was designed to evaluate the effect of lidocaine-soaked packs on pain after ESS. METHODS:A prospective, randomized, double-blind ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2013.27.3942
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Nonallergic rhinitis (NAR) is characterized by nasal symptoms similar to allergic rhinitis (AR) without an IgE-mediated immune response. Limited data are available on the natural history of NAR in its progression toward AR, particularly in children. This study evaluates the development of AR in children who...
journal_title:American journal of rhinology & allergy
pub_type: 临床试验,杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3939
更新日期:2013-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420957853
更新日期:2020-09-11 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2013.27.3889
更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a su...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The "Candy Smell Test" (CST) has been introduced as a new testing method for the evaluation of the human sense of smell. In contrast to other established orthonasal smell tests, the CST addresses the retronasal application of odors, typical for food aroma effects during mastication and swallowing. The aim of...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3611
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe treatment results in patients with sinonasal inverted papilloma and to compare recent classification staging systems. METHODS:We performed a retrospective study of 79 patients with primary paranasal sinus inverted papilloma from 1978 to 2008. RESULTS:The median age at ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3421
更新日期:2010-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3797
更新日期:2012-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3882
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The impact of middle turbinate resection (MTR) on olfaction remains a point of debate in the current literature. Few studies have objectively evaluated olfactory cleft airflow following MTR; thus, the mechanism by which MTR may impact olfaction is poorly understood. It is not known whether the postsurgical c...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418816841
更新日期:2019-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4439
更新日期:2017-05-01 00:00:00
abstract::Background Since the Food and Drug Administration approval of balloon sinuplasty (BSP) in 2005, no nationally representative population-based studies have examined the outcomes and adverse events of BSP. Objective To assess the rates of complications and revision surgery in patients who received BSP, functional endosc...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418782248
更新日期:2018-09-01 00:00:00