Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis.

Abstract:

BACKGROUND:Cystatin C (CysC) is associated with many neurodegenerative disorders and autoimmune diseases, but its relationship with anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. METHODS:Serum levels of CysC were determined in 66 patients with anti-NMDAR encephalitis and 115 healthy controls. Of the 66 patients, 30 had a follow-up evaluation at 3 months after admission. Association of CysC with anti-NMDAR encephalitis and its clinical parameters were evaluated in the patients. RESULTS:The serum levels of CysC were significantly lower in patients with anti-NMDAR encephalitis than in controls (0.70 ± 0.13 vs 0.83 ± 0.17 mg/mL, P < .001). Disease severity and disease duration were significantly associated with CysC levels. Furthermore, a follow-up evaluation revealed that after treatment anti-NMDAR encephalitis patients had significantly increased serum CysC levels (P < .001) and significantly decreased modified Rankin Scale (mRS) scores (P < .001) compared with before treatment. In addition, a significant negative correlation was observed between the change in CysC levels and the change in mRS scores (r = -.700, P < .001). CONCLUSION:Our results show that the serum levels of CysC are associated with anti-NMDAR encephalitis and its clinical parameters and that the changes in CysC levels correlate with therapeutic effect. Therefore, our findings provide new insights into the association between serum CysC and anti-NMDAR encephalitis.

journal_name

Acta Neurol Scand

authors

Shu Y,Chang Y,Wu H,Li J,Cao B,Sun X,Wang J,Peng L,Hu X,Yu X,Qiu W

doi

10.1111/ane.12894

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

515-522

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

137

pub_type

杂志文章
  • Gender differences in disability and health-related quality of life in patients with Parkinson's disease treated with stereotactic surgery.

    abstract:OBJECTIVES:To investigate eventual differences between women and men with Parkinson's disease (PD) before and after surgery, with respect to clinical status, disability and health-related quality of life (HRQoL). MATERIAL AND METHODS:Twenty-four men and 14 women with PD received a total of 46 surgical procedures (pall...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00092.x

    authors: Hariz GM,Lindberg M,Hariz MI,Bergenheim AT

    更新日期:2003-07-01 00:00:00

  • Cavernous hemangioma of the spinal cord - conservative or operative management?

    abstract::Once believed to be extremely uncommon, due to magnetic resonance imaging cavernous hemangiomas of the spinal cord are detected with increasing frequency. Management of both symptomatic and asymptomatic intramedullary cavernous hamangiomas is therefore of growing importance. However, experience with treatment and foll...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00675.x

    authors: Kondziella D,Brodersen P,Laursen H,Hansen K

    更新日期:2006-10-01 00:00:00

  • The frequency of alcohol consumption is associated with the stroke mortality.

    abstract:OBJECTIVES:The purpose of this study was to examine the association between the frequency of alcohol consumption and stroke mortality among eastern Finnish men. MATERIAL AND METHODS:This study is a population-based sample of men with an average follow-up of 20.2 years. A total of 2609 men with no history of stroke at ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12243

    authors: Rantakömi SH,Kurl S,Sivenius J,Kauhanen J,Laukkanen JA

    更新日期:2014-08-01 00:00:00

  • M-wave analysis and passive tilt in patients with different degrees of carotid artery disease.

    abstract:BACKGROUND AND PURPOSE:Carotid artery disease (CAD) is able to critically impair cerebral autoregulation which increases the risk for stroke. As therapeutic strategy largely depends on the degree of CAD, we investigated whether this gradation is also related to significant changes in autoregulatory capacity. We applied...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00210.x

    authors: Haubrich C,Klemm A,Diehl RR,Möller-Hartmann W,Klötzsch C

    更新日期:2004-03-01 00:00:00

  • Body temperature and major neurological improvement in tPA-treated stroke patients.

    abstract:BACKGROUND:Major neurological improvement (MNI) at 24 hours represents a marker of early recanalization in ischaemic stroke. Although low body temperature is considered neuroprotective in cerebral ischaemia, some studies have suggested that higher body temperature may promote clot lysis in the acute phase of ischaemic ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12184

    authors: Kvistad CE,Thomassen L,Waje-Andreassen U,Logallo N,Naess H

    更新日期:2014-05-01 00:00:00

  • Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson's disease.

    abstract::OBJECTIVES - Determine whether bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post-surgery weight gain. MATERIALS AND METHODS - This prospective study included 20 patients wh...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01469.x

    authors: Escamilla-Sevilla F,Pérez-Navarro MJ,Muñoz-Pasadas M,Sáez-Zea C,Jouma-Katati M,Piédrola-Maroto G,Ramírez-Navarro A,Mínguez-Castellanos A

    更新日期:2011-10-01 00:00:00

  • Cerebrospinal fluid investigations in multi-infarct dementia and senile dementia.

    abstract::Thirty-eight demented patients were clinically investigated and classified into a multi-infarct dementia (MID) and senile dementia (SD) group. Total protein, albumin, immunoglobulin G, agar gel electrophoretic protein and iso-electric focusing pattern were determined in CSF and serum as well as the lactate dehydrogena...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1981.tb04380.x

    authors: Wikkelsø C,Blomstrand C,Nordquist P

    更新日期:1981-07-01 00:00:00

  • Plantar stimulation alters brain connectivity in idiopathic Parkinson's disease.

    abstract:OBJECTIVE:Individuals with Parkinson's disease (PD) and freezing of gait (FOG) present peripheral and central sensitivity disturbances that impair motor performance. This study aimed to investigate long-term effects of plantar sensory stimulation on brain activity, brain connectivity, and gait velocity of individuals w...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ane.13253

    authors: Pagnussat AS,Salazar AP,Pinto C,Redivo Marchese R,Rieder CRM,Alves Filho JO,Franco AR,Kleiner AFR

    更新日期:2020-09-01 00:00:00

  • Painful legs and moving toes. A report of 3 cases with neurophysiological studies.

    abstract::3 patients with the condition of "painful legs and moving toes" are reported. The etiology was unknown in 2 of them, but in 1 patient the symptoms were temporarily relieved by surgery for a lumbar herniated disc. The movements restarted 6 months after surgery. EMG studies showed near rhythmical muscle action potential...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1982.tb04526.x

    authors: Wulff CH

    更新日期:1982-08-01 00:00:00

  • Cerebrovascular disease in children.

    abstract::Stroke although rare in children, is an important cause of morbidity in the paediatric age group. Over a period of 8 years, 43 children (17 boys and 26 girls) in the age groups of 1-16 years (mean 8.02 yrs) presented with stroke which constituted 10% of all strokes in the young and 0.7% of all paediatric admissions. T...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1994.tb02716.x

    authors: Nagaraja D,Verma A,Taly AB,Kumar MV,Jayakumar PN

    更新日期:1994-10-01 00:00:00

  • Quality of life in Parkinson's disease: A gender-specific perspective.

    abstract:OBJECTIVES:The epidemiology, manifestations, and course of Parkinson's disease (PD) may differ in men and women. Assessments of severity of the illness and quality of life (QoL), and the burden on their caregivers (CG) may change as the disease advances. We determined gender differences in assessment by patients with P...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.13095

    authors: Balash Y,Korczyn AD,Migirov AA,Gurevich T

    更新日期:2019-07-01 00:00:00

  • Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study.

    abstract:OBJECTIVES:Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI). METHODS:Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinical...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00661.x

    authors: Ishiwata A,Sakayori O,Minoshima S,Mizumura S,Kitamura S,Katayama Y

    更新日期:2006-08-01 00:00:00

  • Executive dysfunction in non-demented Parkinson's disease patients with hallucinations.

    abstract:OBJECTIVE:We investigated executive function in Parkinson's disease (PD) patients, and focused on executive dysfunction in PD with hallucinations, but without dementia. METHODS:PD patients were classified by cognitive or neuropsychotic status as PD group, PD with vivid dreaming group, PD with hallucinations group and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00933.x

    authors: Imamura K,Wada-Isoe K,Kitayama M,Nakashima K

    更新日期:2008-04-01 00:00:00

  • Altered blood-brain-barrier function in Alzheimer's disease?

    abstract::Alzheimer's disease (AD) and vascular dementia (VD) are the two most common causes of dementia. As yet, no definitive biological antemortem marker has been established for differential diagnosis of AD or VD. In this study, proteins of cerebrospinal fluid (CSF) from AD, VD and control patients were analyzed by two-dime...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1994.tb01660.x

    authors: Mattila KM,Pirttilä T,Blennow K,Wallin A,Viitanen M,Frey H

    更新日期:1994-03-01 00:00:00

  • Risk factors for mortality in patients with anti-NMDA receptor encephalitis.

    abstract:OBJECTIVE:Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder with a mortality of 5%-7%, but few studies have focused on the predictors of death in this disease. In this study, we aim to investigate predictors and causes of death in patients with anti-NMDAR encephalitis. METHODS:In ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12723

    authors: Chi X,Wang W,Huang C,Wu M,Zhang L,Li J,Zhou D

    更新日期:2017-10-01 00:00:00

  • Superior cerebellar artery territory stroke.

    abstract:OBJECTIVES:The purpose of this study was to clarify etiologic factors, prior symptoms and clinical features of isole superior cerebellar artery (SCA) territory infarcts. METHODS:All data were collected from consecutive 21 patients with isole SCA infarcts involved on computerized tomography. RESULTS:The risk factors i...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb07310.x

    authors: Erdemoglu AK,Duman T

    更新日期:1998-10-01 00:00:00

  • Genetic factors in temporal lobe epilepsy.

    abstract::Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb05833.x

    authors: Jensen I

    更新日期:1975-11-01 00:00:00

  • Cigarette smoking and risk of primary intracerebral haemorrhage. A population-based case-control study.

    abstract::From September 1985 to December 1989 a total of 158 patients had primary intracerebral haemorrhage in the population of 116,000 in the Jyväskylä Region, Central Finland. All had the diagnosis confirmed by either computerised tomography or necropsy, and information on cigarette smoking habits was available in 155 patie...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04119.x

    authors: Fogelholm R,Murros K

    更新日期:1993-05-01 00:00:00

  • Antiepileptic drugs, foetal malformations and spontaneous abortions.

    abstract:BACKGROUND:Some recent studies have found an association between foetal malformations in earlier antiepileptic drug (AED)-exposed pregnancies and an increased hazard of such malformations in subsequent pregnancies. We investigated this matter further, and also considered the possible role of spontaneous abortions in pr...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12672

    authors: Vajda FJ,O'Brien TJ,Graham JE,Hitchcock AA,Lander CM,Eadie MJ

    更新日期:2017-03-01 00:00:00

  • Incidence of the urological tumours in patients suffering from multiple sclerosis.

    abstract:OBJECTIVES:The goal of this study was to evaluate the incidence of urological malignancies in MS patients using active screening. MATERIAL AND METHODS:A total of 495 MS patients (141 men, 354 women, age of 42±13.4) were included in the study. The duration of disease was 12.3±11 years, and the EDSS score was 4.3 (±2.5)...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12264

    authors: Krhut J,Hradilek P,Nemec D,Tvrdik J,Zapletalova O,Zvara P

    更新日期:2014-09-01 00:00:00

  • Cerebrospinal fluid levels of cyclic nucleotides in meningitis and idiopathic polyneuritis.

    abstract::Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) were measured in cerebrospinal fluid (CSF) and plasma from 7 patients with bacterial meningitis, 9 patients with serous meningitis, 5 patients with idiopathic polyneuritis and 15 reference patients. A significantly (P less than...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1984.tb07796.x

    authors: Lerche A,Svenson M,Wiik A

    更新日期:1984-03-01 00:00:00

  • Long-term effect of intravenous immunoglobulin on anti-MuSK antibody-positive myasthenia gravis.

    abstract::Anti-muscle-specific receptor tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) patients show various responses to conventional immunosuppressive treatment and some patients are resistant to these therapies. We report a 50-year-old Japanese man with anti-MuSK antibody-positive MG, who showed no or poor r...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00877.x

    authors: Shibata-Hamaguchi A,Samuraki M,Furui E,Iwasa K,Yoshikawa H,Hayashi S,Yamada M

    更新日期:2007-12-01 00:00:00

  • Coping strategies as related to medical and demographic data in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and their relationships with medical and demographic data. METHODS:A total of 49 subjects were asked to fill out a document that would provide their demographic and medical data. Then, each o...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01513.x

    authors: Montel S,Albertini L,Spitz E

    更新日期:2012-02-01 00:00:00

  • Perampanel, an AMPA receptor antagonist: From clinical research to practice in clinical settings.

    abstract::Epileptic seizures are refractory to treatment in approximately one-third of patients despite the recent introduction of many newer antiepileptic drugs (AEDs). Development of novel AEDs therefore remains a high priority. Perampanel is a first-in-class non-competitive selective AMPA receptor antagonist with a unique me...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/ane.12879

    authors: Tsai JJ,Wu T,Leung H,Desudchit T,Tiamkao S,Lim KS,Dash A

    更新日期:2018-04-01 00:00:00

  • Stroke in children under 16 years of age. Clinical and etiological difference with adults.

    abstract:OBJECTIVES:The aim of this study was to re-evaluate the clinical features of stroke in children, their outcome and the place of the different mechanisms, in the light of CT-scan and magnetic resonance imaging. METHODS:A 10-year review of the Dijon Childhood Neurology Clinic experience (1985-1995) identified 54 patient...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1997.tb00306.x

    authors: Giroud M,Lemesle M,Madinier G,Manceau E,Osseby GV,Dumas R

    更新日期:1997-12-01 00:00:00

  • Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life.

    abstract:BACKGROUND AND PURPOSE:Pain is common in post-stroke patients and has been shown to be associated with depression, fatigue, and decreased quality of life (QOL). However, studies examining different types of post-stroke pain are scarce. We investigated differences in the related factors and their QOL impacts between mus...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12617

    authors: Choi-Kwon S,Choi SH,Suh M,Choi S,Cho KH,Nah HW,Song H,Kim JS

    更新日期:2017-04-01 00:00:00

  • A case of anorexia nervosa with acute renal failure resulting from rhabdomyolysis.

    abstract::Symptoms of acute renal failure were observed in an anorexia patient who had a history of frequent vomiting. The acute renal failure might have resulted from rhabdomyolysis subsequent to a disturbance of electrolyte balance. This acute renal failure might have resulted in death if not treated. We postulate that even a...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb00935.x

    authors: Abe K,Mezaki T,Hirono N,Udaka F,Kameyama M

    更新日期:1990-01-01 00:00:00

  • Comparison of concentration of orosomucoid in serum and cerebrospinal fluid in different neurological diseases.

    abstract::We compared orosomucoid levels in cerebrospinal fluid (CSF) in patients with aseptic meningitis, multiple sclerosis, ischemic and hemorrhagic stroke, CNS-affecting leukemia/lymphoma, and CNS-tumor with the levels in a reference group not having neurologic diseases. Because of possible blood brain barrier damage, we co...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1987.tb05454.x

    authors: Vrethem M,Ohman S,von Schenck H,Forsberg P,Olsson JE

    更新日期:1987-05-01 00:00:00

  • Herpes simplex virus type 2 DNA detected in cerebrospinal fluid of 9 patients with Mollaret's meningitis.

    abstract::We present clinical and virological data on 9 patients, 7 women and 2 men aged 31-56 years, with recurrent aseptic meningitis (Mollaret's meningitis). Polymerase chain reaction detected Herpes simplex virus type 2 DNA in cerebrospinal fluid samples from all patients collected during their latest attacks of meningitis....

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb07296.x

    authors: Jensenius M,Myrvang B,Størvold G,Bucher A,Hellum KB,Bruu AL

    更新日期:1998-09-01 00:00:00

  • Accuracy of self-assessment of the minimal record of disability in patients with multiple sclerosis.

    abstract::We tested the validity of a self-administered version of the minimal record of disability (MRD) for multiple sclerosis (MS) by measuring the agreement level between patients' self-assessment and neurologists' independent ratings. 96 MS patients and 4 neurologists took part in the experiment; the agreement level was me...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04073.x

    authors: Solari A,Amato MP,Bergamaschi R,Logroscino G,Citterio A,Bochicchio D,Filippini G

    更新日期:1993-01-01 00:00:00