Comparison of concentration of orosomucoid in serum and cerebrospinal fluid in different neurological diseases.

Abstract:

:We compared orosomucoid levels in cerebrospinal fluid (CSF) in patients with aseptic meningitis, multiple sclerosis, ischemic and hemorrhagic stroke, CNS-affecting leukemia/lymphoma, and CNS-tumor with the levels in a reference group not having neurologic diseases. Because of possible blood brain barrier damage, we corrected for orosomucoid derived from serum by using the orosomucoid index, i.e. (CSF/serum orosomucoid)/(CSF/serum albumin). Elevated CSF orosomucoid was found in several diseases. In no case, however, was there any evidence of intrathecal synthesis of the protein. We concluded that CSF orosomucoid determination, when used as the only, measure, is of limited clinical value.

journal_name

Acta Neurol Scand

authors

Vrethem M,Ohman S,von Schenck H,Forsberg P,Olsson JE

doi

10.1111/j.1600-0404.1987.tb05454.x

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

328-31

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

75

pub_type

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