Abstract:
BACKGROUND:Panic disorder (PD) occurs in 3.4-4.7% of the general population. Although accumulating evidence suggests that some inflammatory processes play a role in the pathophysiology of mental disorders, very few studies have evaluated cytokine levels in patients with PD. The aim of the present study was to systematically review the characteristic cytokine profile of PD patients and discuss some possibilities for future trials on this common and disabling disorder. METHODS:A comprehensive literature search was carried out in PubMed and Web of Science databases (search terms: "panic disorder" or "panic attacks" and IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, TNF-alpha and INF-gamma). RESULTS:Eleven studies involving measurements of cytokines in PD patients were included in this review article. Increased serum levels of some inflammatory markers such as IL-6, IL-1β and IL-5 were reported in PD patients compared with control subjects. There are some conflicting results regarding IL-2, IL-12, and INF-γ in association with PD. LIMITATIONS:There are discrepant findings in the existing literature regarding PD and cytokines. A significant portion of the recognized heterogeneity may be attributable to variability in assay procedures. The discrepant findings may also have been due to differences in the study populations. CONCLUSIONS:Cytokines induce the production of acute-phase proteins and are linked to neurogenesis, modification of the HPA axis, microglial activation, tryptophan metabolism and an imbalance in excitatory and inhibitory neurotransmission. Investigation of inflammatory biomarkers in PD could contribute to understanding the pathophysiological mechanisms in this debilitating disorder.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Quagliato LA,Nardi AEdoi
10.1016/j.jad.2017.11.094subject
Has Abstractpub_date
2018-03-01 00:00:00pages
91-96eissn
0165-0327issn
1573-2517pii
S0165-0327(17)31529-Xjournal_volume
228pub_type
杂志文章,评审abstract:BACKGROUND:Borna disease virus (BDV) is a virus that naturally infects a broad range of warm-blooded animals. BDV is an enveloped virus, non-segmented, negative-stranded RNA genome and has an organization characteristic of a member of Bornaviridae in the order of Mononegavirale. In the present work we investigated the ...
journal_title:Journal of affective disorders
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abstract::Among 231 manic-depressive patients, 18 (7.8%) had a first- or second-degree relative who had committed suicide. There were no significant differences between the unipolar or bipolar patients for a family history of suicide. The literature is reviewed and the possible implications discussed. ...
journal_title:Journal of affective disorders
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abstract:OBJECTIVE:This study aimed to establish and assess the Back Propagation Neural Network (BPNN) prediction model for suicide attempt, so as to improve the individual prediction accuracy. METHOD:Data was collected from a wide range case-control suicide attempt survey. 659 serious suicide attempters (case group) were rand...
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00153-0
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journal_title:Journal of affective disorders
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abstract:BACKGROUND:The efficacy of psychodynamic therapy (PDT) for depression is debated due to a paucity of high-quality studies. We compared short psychodynamic supportive psychotherapy (SPSP) to cognitive behavioral therapy (CBT) in a randomized clinical trial. We used therapist-rated outcomes to examine how the course of c...
journal_title:Journal of affective disorders
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pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(95)00095-x
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2006.01.026
更新日期:2006-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00264-1
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS:Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.12.071
更新日期:2016-03-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.07.035
更新日期:2014-12-01 00:00:00
abstract::The authors conducted a longitudinal study on two samples of patients, fulfilling Research Diagnostic Criteria for schizoaffective disorder and for major affective disorder, respectively. The long-term course in patients defined cross-sectionally as schizoaffective was very heterogeneous. Ten different patterns of cou...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(90)90119-s
更新日期:1990-10-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.03.027
更新日期:2010-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.09.025
更新日期:2012-06-01 00:00:00
abstract::Sulpiride, in this open study of acute manic patients, had a clear antimanic action with all eight patients responding to sulpiride treatment without the need for other antipsychotic drugs. Plasma prolactin concentrations were increased and oestrogen-stimulated neurophysin concentrations decreased by sulpiride but wer...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/0165-0327(89)90064-5
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA an...
journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jad.2009.09.001
更新日期:2010-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2018.04.047
更新日期:2018-08-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.03.001
更新日期:2016-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.07.043
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2003.10.004
更新日期:2004-10-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.04.003
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:There is a direct link between a variety of addictions and mood states to which exercise could be relieving. Sugar addiction has been recently counted as another binge/compulsive/addictive eating behavior, differently induced, leading to a high-significant health problem. Regularly exercising at moderate int...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2016.10.035
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:With the possible exception of cyclothymia in artists, there is a paucity of data in the literature on the temperament in different professions. METHODS:For this exploratory study, we sought to generate preliminary data on temperaments among psychiatric outpatients, including physicians (n=41), lawyers (n=3...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2004.08.003
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Interpretation bias, the tendency to interpret ambiguous situations negatively (or to lack a positive bias), is a cognitive vulnerability associated with psychopathology. However, there is a lack of research characterizing this bias in psychiatric samples, including whether it is also a risk factor for suici...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.09.021
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:To devise and evaluate the retention of a new brief training package for non-psychiatrically trained multidisciplinary staff to assess suicide risk and manage suicidal patients, including referral of patients at significant risk to psychiatric staff. METHOD:8 h of interview skills training, using role play ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00080-9
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Studies have suggested that psychiatric comorbidities have major effects on antidepressant resistance in adult patients with major depressive disorder (MDD). However, the association between psychiatric comorbidities and antidepressant resistance remains unclear in adolescents with MDD. METHODS:A total of 1...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.11.038
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:There is a need for brief instruments to screen for depression in adolescents that are valid, reliable and freely available. The aim of this study was to investigate the psychometric properties of a 10-item version of the CESD-R (CESDR-10) in two national adolescent samples. METHODS:Sample 1 consisted of N=...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.02.009
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The stress experienced as an intense and traumatic event can increase the odds of orofacial pain, affect the biomechanics of masticatory system and compromise the periodontal health. This study was conducted to investigate the impact of post-traumatic stress disorder (PTSD) on oral health. METHODS:A case-co...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.05.033
更新日期:2017-09-01 00:00:00