Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.

abstract：:The purpose of this study was to examine changes in motor unit activity in the biceps brachii muscle after an initial (Bout 1) and repeated (Bout 2) session of eccentric exercise separated by 1 wk. Eight subjects (aged 22 ± 2 yr) participated in experimental assessments of neuromuscular function obtained before, immed...

journal_title：Journal of neurophysiology

authors： Dartnall TJ,Nordstrom MA,Semmler JG

更新日期：2011-03-01 00:00:00

abstract：:The purpose of our study was to examine the associations between the performance of older adults on four tests of mobility and the physical capabilities of the lower leg muscles. The assessments included measures of muscle strength, muscle activation, and perceived fatigability. Muscle activation was quantified as the...

journal_title：Journal of neurophysiology

authors： Mani D,Almuklass AM,Hamilton LD,Vieira TM,Botter A,Enoka RM

更新日期：2018-10-01 00:00:00

abstract：:1. The primary functions of the superior colliculus (SC) are thought to include both the spatial localization of sensory stimuli and the initiation of an orienting response. It has been hypothesized that, in cat, both of these SC functions may be influenced by feedback from the extraocular muscles. The present investi...

journal_title：Journal of neurophysiology

authors： Nelson JS,Meredith MA,Stein BE

更新日期：1989-12-01 00:00:00

abstract：:Long-term synaptic depression (LTD) of cerebellar parallel fiber-Purkinje cell synapses is a form of use-dependent synaptic plasticity that may be studied in cell culture. One form of LTD is induced postsynaptically through an mGlu1/Ca influx/protein kinase Cα (PKCα) cascade, and its initial expression requires phosph...

journal_title：Journal of neurophysiology

authors： Linden DJ

更新日期：2012-01-01 00:00:00

abstract：:Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed "dentate waves") in several respects resembled the dentate spikes described for freely moving rats durin...

journal_title：Journal of neurophysiology

authors： Colgin LL,Kubota D,Brucher FA,Jia Y,Branyan E,Gall CM,Lynch G

更新日期：2004-12-01 00:00:00

abstract：:The capabilities of any sensory system are ultimately constrained by the properties of the sensory neurons: the ability to detect and represent stimuli is limited by noise due to spontaneous activity, and optimal decoding in downstream circuitry must be matched to the nature of the encoding performed at the input. Her...

journal_title：Journal of neurophysiology

authors： Arnson HA,Holy TE

更新日期：2011-07-01 00:00:00

abstract：:1. We present a new mathematical description of the complete distribution of electrical responses to stochastic synaptic activity (quantal analysis) that is intended as a model of experiments on central neuronal synapses. Unlike previous treatments, this distribution is calculated for each instant after the release of...

journal_title：Journal of neurophysiology

authors： Blum KI,Idiart MA

更新日期：1994-09-01 00:00:00

abstract：:We used laser scanning photostimulation through a focused UV laser of caged glutamate in an in vitro slice preparation through the rat's somatosensory thalamus to study topography and connectivity between the thalamic reticular nucleus and ventral posterior lateral nucleus. This enabled us to focally stimulate the som...

journal_title：Journal of neurophysiology

authors： Lam YW,Sherman SM

更新日期：2005-10-01 00:00:00

abstract：:The tactile sensations mediated by the whisker-trigeminal system allow rodents to efficiently detect and discriminate objects. These capabilities rely strongly on the temporal and spatial structure of whisker deflections. Subthreshold but also spiking receptive fields in the barrel cortex encompass a large number of v...

journal_title：Journal of neurophysiology

authors： Le Cam J,Estebanez L,Jacob V,Shulz DE

更新日期：2011-08-01 00:00:00

abstract：:In adult songbirds, auditory neurons in the primary auditory forebrain region of field L and a secondary auditory forebrain region of caudal mesopallium (CM) are highly responsive to natural sounds, such as conspecific song. Because these nuclei are involved in sensory representations of songs, we investigated how the...

journal_title：Journal of neurophysiology

authors： Amin N,Doupe A,Theunissen FE

更新日期：2007-05-01 00:00:00

abstract：:Motor control relies on multiple sources of information. To estimate the position and motion of the hand, the brain uses both vision and body-position (proprioception and kinesthesia) senses from sensors in the muscles, tendons, joints, and skin. Although performance is better when more than one sensory modality is pr...

journal_title：Journal of neurophysiology

authors： Wong T,Henriques DY

更新日期：2009-02-01 00:00:00

abstract：:Extracellular recordings of 209 neurons were obtained with carbon fiber-containing multibarrel micropipettes. The cells were isolated in the primary somatosensory cortex of cats anesthetized with barbiturate and classified according to the nature of their response to natural stimuli, the nature of the surrounding mult...

journal_title：Journal of neurophysiology

authors： Dykes RW,Landry P,Metherate R,Hicks TP

更新日期：1984-12-01 00:00:00

abstract：:In rats, forelimb movements are evoked from two cortical regions, the caudal and rostral forelimb areas (CFA and RFA, respectively). These areas are densely interconnected and RFA induces complex and powerful modulations of CFA outputs. CFA and RFA also have interhemispheric connections, and these areas from both hemi...

journal_title：Journal of neurophysiology

authors： Touvykine B,Elgbeili G,Quessy S,Dancause N

更新日期：2020-04-01 00:00:00

abstract：:Spinothalamic (ST) neurons in the C8-T5 segments of the spinal cord were examined for responses to electrical stimulation of the left thoracic vagus nerve (LTV). Seventy-one ST neurons were studied in 39 anesthetized monkeys (Macaca fascicularis). Each neuron could be excited by manipulation of its somatic field and b...

journal_title：Journal of neurophysiology

authors： Ammons WS,Blair RW,Foreman RD

更新日期：1983-10-01 00:00:00

abstract：:1. We reexamined the important areas of conflict in (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced potentiation of the field excitatory postsynaptic potential (EPSP) and, for the first time, investigated the role of mGluRs in EPSP-spike (E-S) coupling. 2. (1S,3R)-ACPD (10 microM) bath applied...

journal_title：Journal of neurophysiology

authors： Breakwell NA,Rowan MJ,Anwyl R

更新日期：1996-11-01 00:00:00

abstract：:The motor pathway responsible for the complex vocalizations of songbirds has been extensively characterized, both in terms of intrinsic and synaptic physiology in vitro and in terms of the spatiotemporal patterns of neural activity in vivo. However, the relationship between the neural architecture of the song motor pa...

journal_title：Journal of neurophysiology

authors： Abarbanel HD,Gibb L,Mindlin GB,Talathi S

更新日期：2004-07-01 00:00:00

abstract：:We recorded local field potentials (LFPs) and single-unit activity simultaneously in the macaque primary visual cortex (V1) and studied their responses to drifting sinusoidal gratings that were chosen to be "optimal" for the single units. Over all stimulus conditions, the LFP spectra have much greater power in the low...

journal_title：Journal of neurophysiology

authors： Henrie JA,Shapley R

更新日期：2005-07-01 00:00:00

abstract：:1. Ca(2+)-dependent K+ currents were studied in large pyramidal neurons (Betz cells) from layer V of cat sensorimotor cortex by use of an in vitro brain slice and single microelectrode voltage clamp. The Ca(2+)-dependent outward current was taken as the difference current obtained before and after blockade of Ca2+ inf...

journal_title：Journal of neurophysiology

authors： Schwindt PC,Spain WJ,Crill WE

更新日期：1992-01-01 00:00:00

abstract：:Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+ signaling, but less is known about their role in regulating mitochondrial metabolic function within the CNS. In this study, we demonstrate in area CA3 of rat organotypic hippocampal slice cultures that glutamatergic, serotonergic, and mu...

journal_title：Journal of neurophysiology

authors： Kann O,Kovács R,Heinemann U

更新日期：2003-08-01 00:00:00

abstract：:The perforant path forms a monosynaptic connection between the cells of layer II of the entorhinal cortex and the pyramidal cells in hippocampal area CA3. Although this projection is prominent anatomically, very little is known about the physiological properties of this input. The distal location of these synapses sug...

journal_title：Journal of neurophysiology

authors： Urban NN,Henze DA,Barrionuevo G

更新日期：1998-09-01 00:00:00

abstract：:1. In decerebrate paralyzed cats, we observed the responses of ventral and dorsal medullary inspiratory (I) neurons to two types of vagal afferent input that shorten neural I: lung inflation and vagal electrical stimulation. 2. A study population of 15 I neurons whose firing patterns suggested involvement in the inspi...

journal_title：Journal of neurophysiology

authors： Cohen MI,Huang WX,Barnhardt R,See WR

更新日期：1993-05-01 00:00:00

abstract：:The medial division of the ventral nucleus of the lateral lemniscus (VNLLm) contains a specialized population of neurons that is sensitive to interaural temporal disparities (ITDs), a potent cue for sound localization along the azimuth. Unlike many ITD-sensitive neurons elsewhere in the auditory system, neurons in the...

journal_title：Journal of neurophysiology

authors： Batra R,Fitzpatrick DC

更新日期：2002-08-01 00:00:00

abstract：:1. The hyperpolarization that follows tetanic stimulation was recorded intra-axonally from the internodal region of intramuscular myelinated motor axons. 2. The peak amplitude of the posttetanic hyperpolarization (PTH) that followed stimulation at 20-100 Hz for < or = 35 s increased with increasing train duration, rea...

journal_title：Journal of neurophysiology

authors： Morita K,David G,Barrett JN,Barrett EF

更新日期：1993-11-01 00:00:00

abstract：:Humans quickly and sophisticatedly correct their movements in response to changes in the world, such as when reaching to a target that abruptly changes its location. The vigor of these movement corrections is time-dependent, increasing if the time left to make the correction decreases, which can be explained by optima...

journal_title：Journal of neurophysiology

authors： Oostwoud Wijdenes L,van Beers RJ,Medendorp WP

更新日期：2019-09-01 00:00:00

abstract：:A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon imaging, optogenetics, lesions, and microdialysis, require access to the brain through the skull. Ideally, the necessary craniotomies could be performed in a repeatable and automated fashion, without damaging the underlying br...

journal_title：Journal of neurophysiology

authors： Pak N,Siegle JH,Kinney JP,Denman DJ,Blanche TJ,Boyden ES

更新日期：2015-06-01 00:00:00

abstract：:1. The individual joint rotations of a movement sequence might be controlled either by a central motor plan or by motion-dependent (i.e., kinesthetic) sensory input. Most previous research has focused on how the nervous system uses central motor plans to control movement sequences. This study examined how the nervous ...

journal_title：Journal of neurophysiology

authors： Cordo PJ

更新日期：1990-01-01 00:00:00

abstract：:Echolocating bats use echoes of their sonar emissions to determine the position and distance of objects or prey. Target distance is represented as a map of echo delay in the auditory cortex (AC) of bats. During a bat's flight through a natural complex environment, echo streams are reflected from multiple objects along...

journal_title：Journal of neurophysiology

authors： Greiter W,Firzlaff U

更新日期：2017-06-01 00:00:00

abstract：:To perform goal-oriented hand movement, humans combine multiple sensory signals (e.g., vision and proprioception) that can be encoded in various reference frames (body centered and/or exo-centered). In a previous study (Tagliabue M, McIntyre J. PLoS One 8: e68438, 2013), we showed that, when aligning a hand to a remem...

journal_title：Journal of neurophysiology

authors： Arnoux L,Fromentin S,Farotto D,Beraneck M,McIntyre J,Tagliabue M

更新日期：2017-09-01 00:00:00

abstract：:Fear conditioning involves the transmission of sensory stimuli to the amygdala from the thalamus and cortex. These input synapses are prime candidates for sites of plasticity critical to the learning in fear conditioning. Because N-methyl-D-aspartate (NMDA)-dependent mechanisms have been implicated in fear learning, w...

journal_title：Journal of neurophysiology

authors： Weisskopf MG,LeDoux JE

更新日期：1999-02-01 00:00:00

abstract：:Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists block...

journal_title：Journal of neurophysiology

authors： Wang P,Slaughter MM

更新日期：2005-06-01 00:00:00