Amplification of perforant-path EPSPs in CA3 pyramidal cells by LVA calcium and sodium channels.

Abstract:

:The perforant path forms a monosynaptic connection between the cells of layer II of the entorhinal cortex and the pyramidal cells in hippocampal area CA3. Although this projection is prominent anatomically, very little is known about the physiological properties of this input. The distal location of these synapses suggests that somatically recorded perforant-path excitatory postsynaptic potentials (EPSPs) may be influenced by the activation of voltage-dependent channels in CA3 cells. We observed that perforant-path EPSPs are reduced (by approximately 25%) by blockade of postsynaptic low-voltage-activated calcium and sodium channels, indicating that perforant-path EPSPs are amplified by the activation of these channels. These data suggest that the perforant path may represent an important and highly modifiable direct connection between the entorhinal cortex and area CA3.

journal_name

J Neurophysiol

authors

Urban NN,Henze DA,Barrionuevo G

doi

10.1152/jn.1998.80.3.1558

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

1558-61

issue

3

eissn

0022-3077

issn

1522-1598

journal_volume

80

pub_type

杂志文章
  • Corticoreticular pathways in the cat. II. Discharge activity of neurons in area 4 during voluntary gait modifications.

    abstract::We propose that the descending command from area 4 that is responsible, in part, for the change in limb trajectory required to step over an obstacle in one's path also plays a role in triggering the anticipatory postural modifications that accompany this movement. To test this hypothesis, we recorded the discharge cha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.406

    authors: Kably B,Drew T

    更新日期:1998-07-01 00:00:00

  • Cortical mechanisms underlying tactile discrimination in the monkey. I. Role of primary somatosensory cortex in passive texture discrimination.

    abstract::1. The discharge patterns of 359 single neurons in the hand representation of primary somatosensory cortex (SI) of two monkeys (Macaca mulatta) were recorded during the performance of a passive texture discrimination task with the contralateral hand (104 in area 3b, 149 in area 1, and 106 in area 2). Three nyloprint s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.3382

    authors: Tremblay F,Ageranioti-Bélanger SA,Chapman CE

    更新日期:1996-11-01 00:00:00

  • Human gaze stabilization during natural activities: translation, rotation, magnification, and target distance effects.

    abstract::Stability of images on the retina was determined in 14 normal humans in response to rotational and translational perturbations during self-generated pitch and yaw, standing, walking, and running on a treadmill. The effects on image stability of target distance, vision, and spectacle magnification were examined. During...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.4.2129

    authors: Crane BT,Demer JL

    更新日期:1997-10-01 00:00:00

  • Internalizing agency of self-action: perception of one's own hand movements depends on an adaptable prediction about the sensory action outcome.

    abstract::Extensive work on learning in reaching and pointing tasks has demonstrated high degrees of plasticity in our ability to optimize goal-directed motor behavior. However, studies focusing on the perceptual awareness of our own actions during motor adaptation are still rare. Here we present the first simultaneous investig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00104.2006

    authors: Synofzik M,Thier P,Lindner A

    更新日期:2006-09-01 00:00:00

  • Responses of reticulospinal neurons in intact lamprey to vestibular and visual inputs.

    abstract::A lamprey maintains the dorsal-side-up orientation due to the activity of postural control system driven by vestibular input. Visual input can affect the body orientation: illumination of one eye evokes ipsilateral roll tilt. An important element of the postural network is the reticulospinal (RS) neurons transmitting ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.2.864

    authors: Deliagina TG,Fagerstedt P

    更新日期:2000-02-01 00:00:00

  • A transthalamic olfactory pathway to orbitofrontal cortex in the monkey.

    abstract::1. Evoked potentials restricted to the magnocellular portion of the mediodorsal nucleus (MDmc) of the thalamus were recorded after stimulation of the olfactory bulb (OB) and the posterior orbital cortex of the frontal lobe (OFC). Potentials evoked by stimulation of OB were probably trans-synaptically elicited, while p...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1980.43.1.69

    authors: Yarita H,Iino M,Tanabe T,Kogure S,Takagi SF

    更新日期:1980-01-01 00:00:00

  • A motor area rostral to the supplementary motor area (presupplementary motor area) in the monkey: neuronal activity during a learned motor task.

    abstract::1. The rostromesial agranular frontal cortex of macaque monkey (Macaca fuscata), traditionally defined as the supplementary motor area (SMA), was studied using various physiological techniques to delineate two different areas rostrocaudally. 2. Field and unitary responses to electrical stimulation of the primary motor...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.3.653

    authors: Matsuzaka Y,Aizawa H,Tanji J

    更新日期:1992-09-01 00:00:00

  • Comparison of morphine and kainic acid microinjections into identical PAG sites on the activity of RVM neurons.

    abstract::The rostral ventromedial medulla (RVM) modulates nociception through changes in the activity of two classes of neuron, ON- and OFF-cells. The activity of these neurons is regulated, in part, by input from the periaqueductal gray (PAG). The objective of this study was to determine whether PAG-mediated antinociception i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.4.1707

    authors: Tortorici V,Morgan MM

    更新日期:2002-10-01 00:00:00

  • Weakly modulated spike trains: significance, precision, and correction for sample size.

    abstract::Many single-unit electrophysiological studies of visual cortex have investigated strong evoked responses to simple stimuli such as oriented gratings. Experiments involving other types of stimuli, such as natural scenes, higher-order features, and surface brightness, produce single-unit responses that are more difficul...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00420.2001

    authors: Hung CP,Ramsden BM,Roe AW

    更新日期:2002-05-01 00:00:00

  • Triggering of lordosis reflex in female rats with somatosensory stimulation: quantitative determination of stimulus parameters.

    abstract::1. Pressure on the skin of the tail base and perineum of female rats in the range of 40--440 millibars, following bilateral contact with the flanks, was adequate to elicit the lordosis reflex. Hair deflection alone or noxious stimulation was neither sufficient nor necessary for lordosis behavior to occur. 2. For a giv...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1979.42.1.195

    authors: Kow LM,Montgomery MO,Pfaff DW

    更新日期:1979-01-01 00:00:00

  • Population encoding of spatial frequency, orientation, and color in macaque V1.

    abstract::1. We recorded local field potentials in the parafoveal representation in the primary visual cortex of anesthetized and paralyzed macaque monkeys with a multicontact electrode that provided for sampling of neural activity at 16 sites along a vertical penetration. Differential recordings at adjacent contacts were trans...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.5.2151

    authors: Victor JD,Purpura K,Katz E,Mao B

    更新日期:1994-11-01 00:00:00

  • Inward currents underlying action potentials in rat adrenal chromaffin cells.

    abstract::1. Current- and voltage-clamp studies were conducted on isolated rat adrenal chromaffin cells to identify the voltage-dependent ion channels mediating inward currents. 2. Mean resting membrane potential of the isolated cells was -62 +/- 3 (SE) mV. Evoked action potentials were both Na+ and Ca2+ based, and whole cell v...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.2.1195

    authors: Hollins B,Ikeda SR

    更新日期:1996-08-01 00:00:00

  • Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans.

    abstract::The pharynx of C. elegans is a rhythmically active muscle that pumps bacteria into the gut of the nematode. This activity is maintained by action potentials, which qualitatively bear a resemblance to vertebrate cardiac action potentials. Here, the ionic basis of the resting membrane potential and pharyngeal action pot...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00233.2001

    authors: Franks CJ,Pemberton D,Vinogradova I,Cook A,Walker RJ,Holden-Dye L

    更新日期:2002-02-01 00:00:00

  • Contrasting speed-accuracy tradeoffs for eye and hand movements reveal the optimal nature of saccade kinematics.

    abstract::In contrast to hand movements, the existence of a neural representation of saccade kinematics is unclear. Saccade kinematics is typically thought to be specified by motor error/desired displacement and generated by brain stem circuits that are not penetrable to voluntary control. We studied the influence of instructed...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00329.2017

    authors: Gopal A,Jana S,Murthy A

    更新日期:2017-09-01 00:00:00

  • Development of thalamocortical response transformations in the rat whisker-barrel system.

    abstract::Extracellular single-unit recordings were used to characterize responses of thalamic barreloid and cortical barrel neurons to controlled whisker deflections in 2, 3-, and 4-wk-old and adult rats in vivo under fentanyl analgesia. Results indicate that response properties of thalamic and cortical neurons diverge during ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01063.2007

    authors: Shoykhet M,Simons DJ

    更新日期:2008-01-01 00:00:00

  • Prolonged vibration of the biceps brachii tendon reduces time to failure when maintaining arm position with a submaximal load.

    abstract::Vibration reduces the amplitudes of the tendon jerk response and the Hoffmann and stretch reflexes in the muscle exposed to the vibration, yet does not alter the time to task failure when the task involves exerting a submaximal force against a rigid restraint. Because the amplitude of the stretch reflex is greater whe...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00807.2005

    authors: Mottram CJ,Maluf KS,Stephenson JL,Anderson MK,Enoka RM

    更新日期:2006-02-01 00:00:00

  • Intended arm use influences interhemispheric correlation of β-oscillations in primate medial motor areas.

    abstract::To investigate the role of interhemispheric β-synchronization in the selection of motor effectors, we trained two monkeys to memorize and perform multiple two-movement sequences that included unimanual repetition and bimanual switching. We recorded local field potentials simultaneously in the bilateral supplementary m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00379.2016

    authors: Nakajima T,Arisawa H,Hosaka R,Mushiake H

    更新日期:2017-11-01 00:00:00

  • Cholinergic synaptic transmission between proprioceptive afferents and a hind leg motor neuron in the locust.

    abstract::1. The physiology and pharmacology of the connections made by stress-sensitive campaniform sensilla on the proximal dorsal tibia of a locust hind leg with a fast extensor tibiae motor neuron (FETi) have been examined. 2. Mechanical stimulation of a campaniform sensillum on the anterior surface of the tibia elicited bu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.586

    authors: Parker D,Newland PL

    更新日期:1995-02-01 00:00:00

  • Nonprimary auditory thalamic representation of acoustic change.

    abstract::1. The mismatch response, or mismatch negativity (MMN), is a neurophysiologic response to stimulus change. In humans and other animals, the MMN may underlie the ability to discriminate acoustic differences, a fundamental aspect of auditory perception. 2. This study investigated the role of the thalamus in the generati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.3.1270

    authors: Kraus N,McGee T,Littman T,Nicol T,King C

    更新日期:1994-09-01 00:00:00

  • Gustatory neural coding in the monkey cortex: the quality of sweetness.

    abstract::1. We analyzed the activity of single neurons in gustatory cortex of alert cynomolgus monkeys in response to the four basic taste stimuli and to a range of chemicals, all of which are predominantly sweet to humans. 2. We recorded taste-evoked responses from a cortical area that measured 4.0 mm in its anteroposterior e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.2.482

    authors: Plata-Salamán CR,Scott TR,Smith-Swintosky VL

    更新日期:1993-02-01 00:00:00

  • Directional sensitivity of "first trial" reactions in human balance control.

    abstract::Support-surface movements are commonly used to examine balance control. Subjects typically receive a series of identical or randomly interspersed multidirectional balance perturbations and the atypical "first trial reaction" (evoked by the first perturbation) is often excluded from further analysis. However, this proc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90945.2008

    authors: Oude Nijhuis LB,Allum JH,Borm GF,Honegger F,Overeem S,Bloem BR

    更新日期:2009-06-01 00:00:00

  • Visual feature tuning of superior colliculus neural reafferent responses after fixational microsaccades.

    abstract::The primate superior colliculus (SC) is causally involved in microsaccade generation. Moreover, visually responsive SC neurons across this structure's topographic map, even at peripheral eccentricities much larger than the tiny microsaccade amplitudes, exhibit significant modulations of evoked response sensitivity whe...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00077.2020

    authors: Khademi F,Chen CY,Hafed ZM

    更新日期:2020-06-01 00:00:00

  • Effects of 5-HT on thalamocortical synaptic transmission in the developing rat.

    abstract::1. Recent immunocytochemical and receptor binding data have demonstrated a transient somatotopic patterning of serotonin (5-HT)-immunoreactive fibers in the primary somatosensory cortex of developing rats and a transient expression of 5-HT1B receptors on thalamocortical axons from the ventral posteromedial thalamic nu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.5.2438

    authors: Rhoades RW,Bennett-Clarke CA,Shi MY,Mooney RD

    更新日期:1994-11-01 00:00:00

  • Kinetic and stochastic properties of a persistent sodium current in mature guinea pig cerebellar Purkinje cells.

    abstract::Whole cell voltage-clamp techniques were employed to characterize the sodium (Na) conductances in acutely dissociated, mature guinea-pig cerebellar Purkinje cells. Three phenomenological components were noted: two inactivating and a persistent component (I(P)(Na). All exhibited similar sensitivities to tetrodotoxin (T...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.3.1167

    authors: Kay AR,Sugimori M,Llinás R

    更新日期:1998-09-01 00:00:00

  • beta-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor.

    abstract::N-Acetylaspartylglutamate (NAAG) is an agonist at the type 3 metabotropic glutamate receptor (mGluR3), which is coupled to a Gi/o protein. When activated, the mGluR3 receptor inhibits adenylyl cyclase and reduces the cAMP-mediated second-messenger cascade. Long-term potentiation (LTP) in the medial perforant path (MPP...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.3.1097

    authors: Lea PM 4th,Wroblewska B,Sarvey JM,Neale JH

    更新日期:2001-03-01 00:00:00

  • Responses of medullary reticulospinal neurons to sinusoidal stimulation of labyrinth receptors in decerebrate cat.

    abstract::The electrical activity of 168 individual neurons located in the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis, and ventralis, has been recorded in precollicular decerebrate cats during sinusoidal tilt about the longitudinal axis of the whole...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.5.1059

    authors: Manzoni D,Pompeiano O,Stampacchia G,Srivastava UC

    更新日期:1983-11-01 00:00:00

  • Excitatory amino acid response in isolated spiral ganglion cells of guinea pig cochlea.

    abstract::1. The physiological and pharmacological properties of excitatory amino acid (EAA)-induced responses were investigated in acutely isolated spiral ganglion cells of guinea pig by a conventional patch-clamp technique combined with a rapid drug application (Y-tube) method. 2. L-glutamate (Glu) and its agonists, quisquala...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.3.715

    authors: Nakagawa T,Komune S,Uemura T,Akaike N

    更新日期:1991-03-01 00:00:00

  • Effects of mitochondrion on calcium transients at intact presynaptic terminals depend on frequency of nerve firing.

    abstract::The rate and the total amount of Ca2+ elevation in the presynaptic terminals of bullfrog sympathetic ganglia depend on the firing frequency of the terminals. Carbonyl cyanide m-chlorophenylhydrazone (CCCP), a mitochondrial uncoupler, was used for testing whether mitochondrial Ca2+ uptake is one of the mechanisms that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.186

    authors: Peng YY

    更新日期:1998-07-01 00:00:00

  • Alphaxalone activates a Cl- conductance independent of GABAA receptors in cultured embryonic human dorsal root ganglion neurons.

    abstract::Whole cell and cell-attached patch-clamp techniques characterized the neurosteroid anesthetic alphaxalone's (5alpha-pregnane-3alpha-ol-11,20-dione) effects on GABAA receptors and on Cl- currents in cultured embryonic (5- to 8-wk old) human dorsal root ganglion neurons. Alphaxalone applied by pressure pulses from close...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.1.10

    authors: Valeyev AY,Hackman JC,Holohean AM,Wood PM,Katz JL,Davidoff RA

    更新日期:1999-07-01 00:00:00

  • Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.

    abstract::The lateral hypothalamus (LH), which plays a role in homeostatic functions such as appetite regulation, is also linked to arousal and motivational behavior. However, little is known about how these components are encoded in the LH. Thus cynomolgus monkeys were conditioned with two distinct contexts, i.e., an appetitiv...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00247.2018

    authors: Noritake A,Nakamura K

    更新日期:2019-02-01 00:00:00