Timing of medullary late-inspiratory neuron discharges: vagal afferent effects indicate possible off-switch function.

Abstract:

:1. In decerebrate paralyzed cats, we observed the responses of ventral and dorsal medullary inspiratory (I) neurons to two types of vagal afferent input that shorten neural I: lung inflation and vagal electrical stimulation. 2. A study population of 15 I neurons whose firing patterns suggested involvement in the inspiratory OFF-switch (IOS) was selected on the basis of two criteria: late onset of firing and excitation by vagal inputs. 3. Firing in relation to the end of I showed two types of response to vagal inputs. The pre-expiratory onset time (time from initial spike to end of I) was either unchanged (type 1 response in 5/15 neurons) or significantly changed (type 2 response in 10/15 neurons). 4. It is suggested that type 1 neurons, whose firing patterns remain closely locked to the end of I despite considerable changes of I duration, are involved in promoting the IOS, whereas type 2 neurons are either not involved (e.g., late-onset premotor neurons) or are involved at an earlier temporal processing stage.

journal_name

J Neurophysiol

authors

Cohen MI,Huang WX,Barnhardt R,See WR

doi

10.1152/jn.1993.69.5.1784

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

1784-7

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

69

pub_type

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