Abstract:
AIM:To evaluate the efficiency and safety of using statins in combination with ursodeoxycholic acid (UDCA) in patients with this or another liver disease at high risk for cardiovascular events (CVE). SUBJECTS AND METHODS:A register of 262 patients at high risk for CCE who needed statin therapy and have concomitant chronic liver and biliary tract diseases was created in 5 cities of the Russian Federation. RESULTS:After addition of statins or adjustment of their doses, the patients were recommended to include UDCA into their therapy. Six months after stabilization of the dose of statins, the whole group showed a significant reduction in the levels of total cholesterol and low-density lipoprotein (LDL) cholesterol. Assessment of the laboratory parameters responsible for the safety of statin intake revealed no deterioration in the trend in the activity of alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, lactate dehydrogenase, as well as an increase in the serum level of bilirubin. The data obtained using a special questionnaire indicated that 196 patients had taken UDCA and 56 had not. The UDCA and non-UDCA subgroups did not differ in age, weight, or baseline lipid metabolic disturbances. An additional analysis showed that by the end of 6 months, the goal levels of LDL cholesterol in the UDCA and non-UDCA groups were reached in 37 and 20%, respectively (p = 0.01). CONCLUSION:UDCA added to statin therapy in patients at high risk for CVE and concurrent liver diseases contributes to an additional reduction in total cholesterol and LDL cholesterol and prevents enhanced hepatic transaminase activities.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Martsevish SIu,Kutishenko NP,Drozdova LIu,Lerman OV,Nevzorova VA,Reznik II,Shavkuta GV,Iakhontov DA,RACURS study groupdoi
10.17116/terarkh2014861248-52subject
Has Abstractpub_date
2014-01-01 00:00:00pages
48-52issue
12eissn
0040-3660issn
2309-5342journal_volume
86pub_type
杂志文章abstract::The morphofunctional status of red blood cells was studied in patients with terminal renal failure associated with pyo-inflammatory complications treated by means of ultraviolet radiation of autologous blood. The authors have established that ultraviolet radiation of autologous blood results in the increase of the dis...
journal_title:Terapevticheskii arkhiv
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doi:
更新日期:1989-01-01 00:00:00
abstract:AIM:To describe clinical symptoms of sporadic cases of noro- and astroviral infection in adults; to compare a clinical picture and a course of rotaviral infection (R VI), noroviral infection (NVI) and astroviral infection (A VI). MATERIAL AND METHODS:Reverse transcription and polymerase chain reaction (RT-PCR) method ...
journal_title:Terapevticheskii arkhiv
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abstract:AIM:To evaluate the presence and the severity of the complaints (headache, dizziness, memory loss, concentration of attention, sleep disturbances, decreased mood, increased anxiety), the state of cognitive functions, emotional status and quality of night sleep in treatment-naïve middle-aged patients with mild to modera...
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更新日期:1985-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-01-01 00:00:00
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更新日期:2000-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
abstract::The status of the blood kinin system, activity of serum inhibitors of proteinases (alpha 1-protease inhibitor and alpha 2-macroglobulin) as well as indices of activity of trypsin-like proteinases, elastolytic and fibrinolytic activity, free antitryptic activity and complete content of acid stable inhibitors were studi...
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更新日期:2011-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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