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[New directions of pharmacotherapy of immune - inflammatory rheumatic diseases].

Abstract：

:Deciphering immunopathogenesis, expanding the scope of diagnostics and developing new methods for treating human autoimmune diseases are among the priority areas of XXI century medicine. Particularly widely autoimmune pathology is presented in immunoinflammatory rheumatic diseases (IIRD), such as rheumatoid arthritis, systemic lupus erythematosus, systemic scleroderma, systemic vasculitis associated with the synthesis of antineutrophilic cytoplasmic antibodies, Sjogren's syndrome, idiopathic inflammatory myopathies and other other types of others. Deciphering the pathogenesis mechanisms of IIRD created the prerequisites for improving pharmacotherapy, which in the future should lead to a dramatic improvement in the prognosis for these diseases. The review discusses new approaches to IIRD pharmacotherapy associated with the inhibition of tumor necrosis factor-α, interleukin-6 (IL-6), IL-1β, IL-17, IL-23, and the prospects for using Janus kinase inhibitors, depending on the prevailing pathogenesis mechanisms - autoimmunity or autoinflammation. :Расшифровка иммунопатогенеза, расширение возможностей диагностики и разработка новых методов лечения аутоиммунных заболеваний человека относятся к числу приоритетных направлений медицины XXI в. Особенно широко аутоиммунная патология представлена при иммуновоспалительных ревматических заболеваниях (ИВРЗ), таких как ревматоидный артрит, системная красная волчанка, системная склеродермия, системные васкулиты, связанные с синтезом антинейтрофильных цитоплазматических антител, синдром Шегрена, идиопатические воспалительные миопатии и некоторые другие. Расшифровка механизмов патогенеза ИВРЗ создала предпосылки для совершенствования фармакотерапии, что в перспективе должно привести к кардинальному улучшению прогноза при этих заболеваниях. В обзоре обсуждаются новые подходы к фармакотерапии ИВРЗ, связанные с ингибицией фактора некроза опухоли-α, интерлейкина-6 (ИЛ-6), ИЛ-1β, ИЛ-17, ИЛ-23, перспективы применения ингибиторов Янус - киназы, в зависимости от преобладающих механизмов патогенеза - аутоиммунитета или аутовоспаления.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Nasonov EL

doi

10.26442/00403660.2019.08.000406

subject

Has Abstract

pub_date

2019-08-15 00:00:00

pages

98-107

issue

8

eissn

0040-3660

issn

2309-5342

journal_volume

91

pub_type

杂志文章

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