Abstract：
AIM:A comparative analysis of effectiveness of combined therapy including trimetazidine (preductal) and composition of amino acids (glutamic acid, glycin and cystein) in elderly patients with coronary heart disease and angina of functional class II-III (FC II-III). MATERIALS AND METHODS:60 patients (47 females and 13 males, mean age 66.4 +/- 0.5 years) with IHD, angina FC II-III, postinfarction cardiosclerosis and circulatory failure stage I-IIA were randomized into 3 randomized groups. Control patients received conventional antianginal therapy with nitrates, beta-adrenoblockers, calcium antagonists, diuretics, ACI inhibitors, cardiac glycosides and aspirin. Patients of group 1 received conventional treatment + complex of amino acids in dose 100 mg 3 times a day sublingually. Group 2 patients received adjuvant preductal for 20 days in dose 20 mg 3 times a day per os. Assessment was made clinically, with echo-CG data, bimanual isometric loading and Holter 24-h ECG monitoring. RESULTS:All the three methods showed antianginal, hypotensive effects, brought higher tolerance to exercise and improvement of hemodynamics. The basic therapy produced the least effect. CONCLUSION:Metabolic therapy with amino acids and preductal combined with conventional methods brings more pronounced antianginal and hemodynamic effects than combined therapy alone.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Zaslavskaia RM,Kelimberdieva ES,Komissarova IA,Teĭblium MM,Goncharov LF,Goncharova ZF,Akhmetov KZhsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
58-61issue
11eissn
0040-3660issn
2309-5342journal_volume
71pub_type
临床试验,杂志文章,随机对照试验abstract：:Diagnostic algorithms for the recognition of diabetic angiopathies have been developed: an algorithm for the recognition of the most important syndromes of vascular involvement in patients with diabetes mellitus; an algorithm for the recognition of stages of diabetic retinopathy, and an algorithm for the recognition o...
journal_title：Terapevticheskii arkhiv
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更新日期：1986-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
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journal_title：Terapevticheskii arkhiv
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更新日期：1984-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
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更新日期：2000-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：2012-01-01 00:00:00
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更新日期：1988-01-01 00:00:00
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更新日期：1985-01-01 00:00:00
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更新日期：1985-01-01 00:00:00
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更新日期：2006-01-01 00:00:00
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更新日期：1993-01-01 00:00:00
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更新日期：2002-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：1991-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：1989-01-01 00:00:00
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