Abstract：
AIM:To study the effects of enalapril and telmisartan on hemodynamic parameters and diastolic function (DF) of the left ventricle (LV) in patients with type 2 diabetes mellitus (DM) concurrent with arterial hypertension (AH). SUBJECTS AND METHODS:The study included 64 patients (mean age 54.3 +/- 5.2 years) with type 2 DM. For the treatment of AH, Group 1 (n = 31) received enalapril and Group 2 (n = 33) took telmisartan (micardis). Their examination comprised 24-hour blood pressure (BP) monitoring, Holter ECG monitoring, and echocardiography. The fasting and postprandial levels of blood glucose and glycosylated hemoglobin were measured to evaluate the compensation for carbohydrate metabolism. RESULTS:In patients with type 2 DM and elevated BP, LV diastolic dysfunction was detectable in the absence of reduced contractility. LF DF, isovolumetric relaxation time, and the ratio of the peak blood flow velocity during early diastolic filling to that during atrial systole were found to correlate with HbA(1c), diastolic hypertension time index, and the diurnal duration of asymptomatic ST-segment depression. During enalapril therapy, the goal level of BP was achieved in systolic BP (SBP) in 77% of the patients and diastolic BP (DBP) in 64.5%, which was accompanied by reductions in the number of nondippers and night-pickers in 45.4% of cases with no changes in HbA(1c) and LV DF. CONCLUSION:In addition to effective SBP and DBP control with the normalization of their diurnal profiles in 87.5% of the patients with abnormal circadian rhythm, the 24-week course of telmisartan therapy ensures improvements in carbohydrate metabolism and LVDF.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Tatarchenko IP,Pozdniakova NV,Mordovina AG,Morozova OI,Zaĭtseva AVsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
11-5issue
12eissn
0040-3660issn
2309-5342journal_volume
81pub_type
临床试验,杂志文章abstract：:Calcitriol is important in nephroprotective strategy in chronic disease of the kidneys (CDK). However, its long-term use often results in hypercalciemia with metastatic calcification. Compared to calcitriol, paricalcitol (zemplar)--metabolite of vitamin D2--leads to hypercalciemia less frequently, has a more potent ne...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
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journal_title：Terapevticheskii arkhiv
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journal_title：Terapevticheskii arkhiv
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doi：
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journal_title：Terapevticheskii arkhiv
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更新日期：2013-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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更新日期：1996-01-01 00:00:00
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更新日期：1997-01-01 00:00:00
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更新日期：1998-01-01 00:00:00
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journal_title：Terapevticheskii arkhiv
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journal_title：Terapevticheskii arkhiv
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