当前位置： SCI文献检索 > Frontiers in Human Neuroscience期刊下所有文献 > Aberrant cerebellar connectivity in motor and association networks in schizophrenia.

Aberrant cerebellar connectivity in motor and association networks in schizophrenia.

Abstract：

:Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the "cognitive dysmetria" and "dysmetria of thought" models propose that abnormalities of the cerebellum may contribute to schizophrenia signs and symptoms. The cerebellum and cerebral cortex are reciprocally connected via a modular, closed-loop network architecture, but few schizophrenia neuroimaging studies have taken into account the topographical and functional heterogeneity of the cerebellum. In this study, using a previously defined 17-network cerebral cortical parcellation system as the basis for our functional connectivity seeds, we systematically investigated connectivity abnormalities within the cerebellum of 44 schizophrenia patients and 28 healthy control participants. We found selective alterations in cerebro-cerebellar functional connectivity. Specifically, schizophrenia patients showed decreased cerebro-cerebellar functional connectivity in higher level association networks (ventral attention, salience, control, and default mode networks) relative to healthy control participants. Schizophrenia patients also showed increased cerebro-cerebellar connectivity in somatomotor and default mode networks, with the latter showing no overlap with the regions found to be hypoconnected within the same default mode network. Finally, we found evidence to suggest that somatomotor and default mode networks may be inappropriately linked in schizophrenia. The relationship of these dysconnectivities to schizophrenia symptoms, such as neurological soft signs and altered sense of agency, is discussed. We conclude that the cerebellum ought to be considered for analysis in all future studies of network abnormalities in SZ, and further suggest the cerebellum as a potential target for further elucidation, and possibly treatment, of the underlying mechanisms and network abnormalities producing symptoms of schizophrenia.

journal_name

Front Hum Neurosci

journal_title

Frontiers in human neuroscience

authors

Shinn AK,Baker JT,Lewandowski KE,Öngür D,Cohen BM

doi

10.3389/fnhum.2015.00134

subject

Has Abstract

pub_date

2015-03-18 00:00:00

pages

134

issn

1662-5161

journal_volume

pub_type

杂志文章

在线工具

Aberrant cerebellar connectivity in motor and association networks in schizophrenia.