20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.

abstract：:The caseinate and glycated caseinate generated from the transglutaminase-catalyzed reaction of caseinate and oligochitosan were digested using pepsin and trypsin, and the activity of the resultant digests was measured in rat intestinal epithelial cell line (IEC-6) using several biological responses as indicators. Comp...

journal_title：Chemico-biological interactions

authors： Wang XP,Ma CM,Zhao XH

更新日期：2020-09-01 00:00:00

abstract：:4-Trifluoromethylphenol (4-TFMP) was cytotoxic to precision-cut rat liver slices as indicated by loss of intracellular potassium. Intracellular glutathione levels decreased and fluoride ion levels increased in a time and concentration-dependent manner. The cytotoxicity of 4-TFMP did not appear to be due to the release...

journal_title：Chemico-biological interactions

authors： Thompson DC,Perera K,London R

更新日期：2000-04-14 00:00:00

abstract：:The effect of nine dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on in vitro and in vivo lipid peroxidation of liver microsomes as well as on anti-oxidative enzyme activities were studied. Seven of the nine lignans (1 mM) were shown to inhibit Vit C/NADPH induced lipid peroxidation (malondialdehyde...

journal_title：Chemico-biological interactions

authors： Lu H,Liu GT

更新日期：1991-01-01 00:00:00

abstract：:We investigated the chemopreventive effect of p-methoxycinnamic acid (p-MCA), an active phenolic acid of rice bran, turmeric, and Kaemperfia galanga against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 consisted of control rats that rece...

journal_title：Chemico-biological interactions

authors： Sivagami G,Karthikkumar V,Balasubramanian T,Nalini N

更新日期：2012-03-05 00:00:00

abstract：:The organ specificity of tris(2,3-dibromopropyl)phosphate(Tris-BP)-induced DNA damage was investigated in the rat 2 h after a single i.p. injection of 350 mumol/kg. Extensive DNA damage, measured with the alkaline elution method, was found in the kidney, liver and small intestine. Less, but significant DNA damage was ...

journal_title：Chemico-biological interactions

authors： Søderlund EJ,Brunborg G,Dybing E,Trygg B,Nelson SD,Holme JA

更新日期：1992-04-15 00:00:00

abstract：:Bitumens contain traces of polycyclic aromatic compounds (PACs), a part of which will end up in the fumes emitted during hot handling of bitumen-containing products, e.g. during roadpaving. Although exposure of workers to these fumes is low, it might lead to health problems. Studies on bitumen fume condensates (BFCs) ...

journal_title：Chemico-biological interactions

authors： De Méo M,Genevois C,Brandt H,Laget M,Bartsch H,Castegnaro M

更新日期：1996-08-14 00:00:00

abstract：:The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy. Binding affinitie...

journal_title：Chemico-biological interactions

authors： Tipping E,Moore BP,Jones CA,Cohen GM,Ketterer B,Bridges JW

更新日期：1980-11-01 00:00:00

abstract：:Many benzo[b]furan lignans are known to be biologically active in nature. 2-(3'-Methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]furan-3-carbaldehyde (XH-14) is found as a bioactive component isolated from the plant Salvia miltiorrhiza, commonly known as Danshen, which is a traditional Chinese medicine...

journal_title：Chemico-biological interactions

authors： Sung HY,Jun JG,Kang SW,Kim HS,Shin D,Kang IJ,Kang YH

更新日期：2010-12-05 00:00:00

abstract：:Buttiauxella strain S19-1 is a new marine bacterium, isolated from the Baltic Sea, which can degrade steroids. In this report, a meta-genomic approach was used to isolate estradiol inducible genes from S19-1. SalI-fragments from the chromosomal DNA of S19-1 were ligated into plasmid pKEGFP2 bearing an EGFP gene as the...

journal_title：Chemico-biological interactions

authors： Zhang T,Xiong G,Maser E

更新日期：2013-02-25 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of Alzheimer's disease (AD). Our screening study indicated that the water fraction of the methanolic extract of Lycopodiella cernua (L...

journal_title：Chemico-biological interactions

authors： Hung TM,Lee JS,Chuong NN,Kim JA,Oh SH,Woo MH,Choi JS,Min BS

更新日期：2015-10-05 00:00:00

abstract：:In order to assess the role played respectively by the pseudothiourea group and the alkylic chain in the inhibition of protein synthesis and tumour growth caused by compound AHR-1911, a series of eight related substances were studied. The blockade of protein synthesis on liver and Walker carcinoma ribosomes and on sus...

journal_title：Chemico-biological interactions

authors： Carmona A,Gonzalez-Cadavid NF

更新日期：1978-09-01 00:00:00

abstract：:Exposure of mice to 14C-labelled ethene or ethene oxide gave rise to hydroxyethylations of nucleophilic sites in hemoglobin and DNA. The relative amounts of alkylation products of different amino acids in hemoglobin were the same for the two compounds. Furthermore, the ratio between the degree of alkylation of DNA in ...

journal_title：Chemico-biological interactions

authors： Segerbäck D

更新日期：1983-07-15 00:00:00

abstract：:The metabolism and genotoxicity of 1,2-dibromoethane (EDB) and its deuterium substituted analog ( d4EDB ) were studied in isolated rat hepatocytes. There was a marked isotope effect on the metabolism of EDB by hepatocytes. This was due to decreased microsomal oxidation of d4EDB . Cytosolic metabolism of EDB, as measur...

journal_title：Chemico-biological interactions

authors： White RD,Petry TW,Sipes IG

更新日期：1984-04-01 00:00:00

abstract：:Variable temperature 1H-nuclear magnetic resonance (NMR) has been used to study the interaction of the RNA trimer, GpCpA, with the intercalators ethidium bromide and the acridine derivatives; proflavin, 9-amino-acridine, acridine orange, acridine yellow and acriflavin. The complexes formed were studied at nucleic acid...

journal_title：Chemico-biological interactions

authors： Coddington JM,Alkema D,Bell RA,Hughes DW,Neilson T

更新日期：1984-06-01 00:00:00

abstract：:Studies were undertaken to investigate the mechanism of bioactivation and covalent binding of TNT. Incubation of [14C]TNT with rat liver microsomes in the presence of an NADPH generating system resulted in metabolism and covalent binding to microsomal proteins. Time-dependence studies showed that TNT was rapidly reduc...

journal_title：Chemico-biological interactions

authors： Leung KH,Yao M,Stearns R,Chiu SH

更新日期：1995-06-30 00:00:00

abstract：:Resveratrol (3,4',5-trans-trihydroxystilbene) and other hydroxystilbenes exhibit in vitro antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage. The prooxidant effects are held likely to be responsible for their cytotoxic, ant...

journal_title：Chemico-biological interactions

authors： Rüweler M,Gülden M,Maser E,Murias M,Seibert H

更新日期：2009-12-10 00:00:00

abstract：:It has been postulated that reversible, high-affinity binding of 3-methylcholanthrene(MC)-type inducers to a receptor protein (the Ah receptor) in hepatic cytosol is essential for induction of aryl hydrocarbon hydroxylase (AHH) enzymic activity. To test this postulate, the binding affinities of 16 highly-purified, syn...

journal_title：Chemico-biological interactions

authors： Bandiera S,Safe S,Okey AB

更新日期：1982-04-01 00:00:00

abstract：:P-glycoprotein (P-gp) is a membranous ATPase responsible for the multidrug resistance phenotype. The effect on P-gp-mediated transport of anthracyclines of cell irradiation in the presence of 2,2-diphenyl-5-[N-1-(o-azidophenyl)ethylamino]valeronitrile (VP*), a photoactivable analogue of verapamil was studied in viable...

journal_title：Chemico-biological interactions

authors： Mankhetkorn S,Teodori E,Garnier-Suillerot A

更新日期：1999-07-01 00:00:00

abstract：:Inflammation and oxidative stress exert important roles in intestinal ischemia-reperfusion injury (IRI). Lycium barbarum polysaccharides (LBPs) have shown effective antioxidative and immunomodulatory functions in different models. The purpose of the present study was to assess the effects and potential mechanisms of L...

journal_title：Chemico-biological interactions

authors： Yang X,Bai H,Cai W,Li J,Zhou Q,Wang Y,Han J,Zhu X,Dong M,Hu D

更新日期：2013-08-25 00:00:00

abstract：:A cellular model of cardiomyocytes (H9c2 cell line) and mitochondria isolated from mouse liver were used to understand the drug action of BPDZ490 and BPDZ711, two benzopyran analogues of the reference potassium channel opener cromakalim, on mitochondrial respiratory parameters and swelling, by comparing their effects ...

journal_title：Chemico-biological interactions

authors： Mouithys-Mickalad A,Ceusters J,Charif M,El Moualij B,Schoumacher M,Plyte S,Franck T,Bettendorff L,Pirotte B,Serteyn D,de Tullio P

更新日期：2020-11-01 00:00:00

abstract：:Balbisia peduncularis, also known as "Amancay", is a plant of the Ledocarpaceae family that can be found in the Atacama Desert in northern Chile. Infusions of the plant have long being used in traditional herbal medicine. Its chemical composition indicates the presence of flavonoids, which have antioxidant properties....

journal_title：Chemico-biological interactions

authors： Suwalsky M,Oyarce K,Avello M,Villena F,Sotomayor CP

更新日期：2009-05-15 00:00:00

abstract：:The ability of pantoprazole to affect the induction of cytochrome P450 (CYP) 1A subfamily was evaluated and compared with two other proton pump inhibitors, omeprazole and lansoprazole, in primary cultured hepatocytes from female Sprague-Dawley rats. The hepatocytes were cultured for 2 days, followed by treatment for 2...

journal_title：Chemico-biological interactions

authors： Masubuchi N,Okazaki O

更新日期：1997-11-06 00:00:00

abstract：:Aspirin is one of the oldest drugs and has been purported to have multiple beneficial effects, including prevention of cardiovascular disease and cancer, in addition to its original indication for treatment of inflammation, fever and pain. In cancer chemoprevention studies using animal models, two methods of aspirin a...

journal_title：Chemico-biological interactions

authors： Kapetanovic IM,Bauer KS,Tessier DM,Lindeblad MO,Zakharov AD,Lubet R,Lyubimov A

更新日期：2009-05-15 00:00:00

abstract：:Hispidulin, a natural flavone, has been reported to have diverse pharmacological effects, including antifungal, antioxidant, and antithrombotic properties. However, an anti-adipogenic effect has not yet been reported, which is the focus of the current study. Hispidulin suppressed the differentiation of adipocytes and ...

journal_title：Chemico-biological interactions

authors： Lee SG,Kim JS,Min K,Kwon TK,Nam JO

更新日期：2018-09-25 00:00:00

abstract：:6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The combined treatment w...

journal_title：Chemico-biological interactions

authors： Han MA,Woo SM,Min KJ,Kim S,Park JW,Kim DE,Kim SH,Choi YH,Kwon TK

更新日期：2015-02-25 00:00:00

abstract：:The goal of this research was to test the hypothesis that bioactivation reactions could be exploited to deliver and activate mitochondria-targeted antioxidant prodrugs. The concept that bioactivation reactions could be used for prodrug delivery and activation has received little attention. Most bioactivation reactions...

journal_title：Chemico-biological interactions

authors： Anders MW

更新日期：2011-06-30 00:00:00

abstract：:Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhib...

journal_title：Chemico-biological interactions

authors： Chen A,Qin X,Tang Y,Liu M,Wang X

更新日期：2014-10-05 00:00:00

abstract：:Fatty liver is the earliest and most common response of the liver to consumption of excessive alcohol. Steatosis can predispose the fatty liver to develop progressive liver damage. Chief among the many mechanisms involved in development of hepatic steatosis is dysregulation of insulin-mediated adipose tissue metabolis...

journal_title：Chemico-biological interactions

authors： Rasineni K,Kubik JL,Knight KL,Hall L,Casey CA,Kharbanda KK

更新日期：2020-05-01 00:00:00

abstract：:Benzene (B) is a typical micro-pollutant present in air, especially urban air. In this study a possible correlation between personal benzene exposure and S-phenylmercapturic acid (S-PMA) as a biomarker of internal dose was evaluated in a cohort of traffic policemen. The results confirm that S-PMA is significantly corr...

journal_title：Chemico-biological interactions

authors： Bono R,Traversi D,Maestri L,Schilirò T,Ghittori S,Baiocchi C,Gilli G

更新日期：2005-05-30 00:00:00

abstract：:Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess multiple pharmacological activities. In our previous study, Andro had been shown to have potent anti-cancer activity against human colorectal carcinoma Lovo cells by inhibiting cell-c...

journal_title：Chemico-biological interactions

authors： Shi MD,Lin HH,Chiang TA,Tsai LY,Tsai SM,Lee YC,Chen JH

更新日期：2009-08-14 00:00:00