Abstract:
:The recent and growing evidence that the efficacy of a drug can be correlated to target binding kinetics has seeded the development of a multitude of novel methods aimed at computing rate constants for receptor-ligand binding processes, as well as gaining an understanding of the binding and unbinding pathways and the determinants of structure-kinetic relationships. These new approaches include various types of enhanced sampling molecular dynamics simulations and the combination of energy-based models with chemometric analysis. We assess these approaches in the light of the varying levels of complexity of protein-ligand binding processes.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Bruce NJ,Ganotra GK,Kokh DB,Sadiq SK,Wade RCdoi
10.1016/j.sbi.2017.10.001subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1-10eissn
0959-440Xissn
1879-033Xpii
S0959-440X(17)30109-4journal_volume
49pub_type
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