Abstract:
OBJECTIVE:To determine plasma aldosterone concentration (PAC) and plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) values in a population attending a Clinic for Cardiovascular Risk Assessment in Children. METHODS:We assessed ARR and associated factors in a cohort of 287 children (137 female, 4-18 years). Weight and blood pressure (BP) were recorded. PAC (ng/dl) and PRC (mU/l) were measured using direct immunochemiluminescent assays. Data were examined by sex and according to four age classes. RESULTS:Median PAC was similar from the youngest to the oldest age class ranging from 7.5 to 9.9 ng/dl in males and from 11.0 to 12.6 ng/dl in females. Median PRC was also similar across age classes in males ranging from 58.2 to 55.5 mU/l, whereas it progressively decreased from 61.5 to 36.6 mU/l in females (P < 0.01). Median PRC was higher in prepubertal than in pubertal females only (53.6 vs. 40.2 mU/l, P < 0.03). As a result ARR was unchanged with increasing age in males (from 0.18 to 0.19), whereas in females it increased from 0.19 to 0.36 (P < 0.03). After adjusting for body weight, BP and other possible confounders, age was inversely related with PRC and directly with PAC and ARR (P < 0.001 for all), in females only. No relationship was found in both sexes between ARR values, BP, weight and family history of hypertension. CONCLUSION:In our children population, ARR is lower than in adults and diverges with increasing age between sexes, due to the age and puberty driven fall in PRC observed only in females. BP and weight are not associated with ARR distribution.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Genovesi S,Antolini L,Orlando A,Tassistro E,Giussani M,Nava E,Turolo L,Manolopoulou J,Parati G,Morganti Adoi
10.1097/HJH.0000000000001571subject
Has Abstractpub_date
2018-02-01 00:00:00pages
344-352issue
2eissn
0263-6352issn
1473-5598journal_volume
36pub_type
杂志文章abstract:OBJECTIVE:To assess the prevalence and risk markers of arterial hypertension in the context of a rapidly growing urbanization in Africa. DESIGN:A cross-sectional study was performed on a representative sample of inhabitants of Pikine, an urban suburb of Dakar, Senegal. METHODS:Blood pressure was measured by properly ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Left-ventricular hypertrophy (LVH) is a marker of organ damage in hypertension and helps stratifying cardiovascular risk. Initial left-ventricular mass (LVM) is also a predictor of progression to hypertension, independently of initial blood pressure (BP) and other confounders. OBJECTIVES:To evaluate whether...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328343ce32
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Recent reports have demonstrated increased cardiac risk, and an association with essential hypertension in patients with panic disorder. The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous ou...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200212000-00025
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:We examined the relation between cardiovascular reactivity (the response of the cardiovascular system to psychological stress) and the severity and progression of carotid atherosclerosis. METHODS:Using duplex ultrasonography, we measured the change in the area of all detectable plaques in the extracranial c...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715010-00004
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:The global morbidity and mortality related to hypertension and associated disorders increases continuously and novel therapeutic strategies are still in high demand. Increasing evidence suggests the important role in blood pressure regulation of cytochrome P-450-dependent metabolites of arachidonic acid. Epo...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002462
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:The pathogenesis of atherosclerosis, a chronic inflammatory disease, is influenced by the renin-angiotensin system and especially by angiotensin II subtype 1 (AT1) receptor activation. Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000242415.73406.17
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Hypertension is a complex trait with an ill-defined genetic predisposition, in which adrenergic mechanisms seem to be involved even at the early stages. Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholami...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200207000-00020
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE(S):To study the changes in macrophage inducible nitric oxide synthase (iNOS) activity, plasma levels of nitrite, lipid peroxidation (LPO) and melatonin in human essential hypertension before and 6 months after 4 mg/day lacidipine treatment. DESIGN:The study was carried out in a total of 25 subjects--11 healt...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1097/00004872-200403000-00027
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199509000-00004
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Hypertension-induced renal injury is characterized by inflammation, fibrosis and proteinuria. Previous studies have demonstrated that N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) inhibits renal damage following diabetes mellitus and antiglomerular basement membrane nephritis. However, its effects on low-renin hyperten...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834103ee
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To carry out a population-based evaluation of withdrawal of treatment in primary care using repeated ambulatory blood pressure monitoring (ABPM) assessment to avoid subjecting patients to prolonged periods of excess risk. METHOD:Patients from two community practices (total population 11 034 patients) being a...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715120-00021
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Arterial stiffness measures such as pulse wave velocity (PWV) have a known dependence on actual blood pressure, requiring consideration in cardiovascular risk assessment and management. Given the impact of ageing on arterial wall structure, the pressure-dependence of PWV may vary with age. METHODS:Using a n...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000407
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:An increased inter-arm SBP difference (IASBPD) is associated with mortality and cardiovascular events, as well as peripheral vascular disease, which is attributed to subclavian stenosis. The aim of the present study was to investigate the association between the IASBPD and incident chronic kidney disease (CKD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001931
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Caffeine is the most widely used pharmacologically active substance. Aortic elastic properties and arterial wave reflection are important factors for the efficient performance of the cardiovascular system, as well as prognosticators of cardiovascular risk. We investigated the effect of caffeine on aortic elas...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200303000-00022
更新日期:2003-03-01 00:00:00
abstract::Systolic (SBP), diastolic (DBP) and mean [MBP = diastolic + 1/3 (systolic - diastolic)] blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198907000-00011
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:The physiopathological mechanisms implicated in hypertensive heart disease are multi-factorial, including myocyte hypertrophy, apoptosis and myocardial remodelling. In this process, some hormonal and local growth factors have a regulatory influence. The aim of this study was to evaluate the potential role of ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000493
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS:Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimate...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001749
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Studies of experimental animals show glomerular hypertension to be important in the progression of glomerular disease. We evaluated this connection clinically by examining the relationship between glomerular hemodynamics and histological changes in patients with immunoglobulin (Ig)A nephropathy. METHODS:The ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200018010-00015
更新日期:2000-01-01 00:00:00
abstract:CLINICAL STUDIES:In clinical renal transplantation studies, recipients of a renal graft from a donor with a genetic predisposition to hypertension had higher blood pressures and required more antihypertensive treatment than recipients of a renal graft from a normotensive donor. In addition, blood pressure normalization...
journal_title:Journal of hypertension
pub_type: 社论
doi:10.1097/00004872-199309000-00001
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the mean levels of blood pressure and hypertension (> or = 140 mmHg systolic or > or = 90 mmHg diastolic pressure or on treatment for hypertension) in the adult English population, and to evaluate any changes in the efficacy of hypertension management between 1994 and 2003. DESIGN/METHODS:Cross-s...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000226210.95936.bc
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the capacity of norepinephrine (NE) to induce hypertrophic remodeling of small arteries in rats, and to determine the involvement of endothelin (ET) to initiate and maintain it. DESIGN AND RESULTS:Treatment with NE (2.5 microg/kg per min) for 14 or 28 days produced a simil...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-200110000-00014
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:Metabolic syndrome (MetS) is associated with uncontrolled blood pressure (BP), despite use of aggressive therapy. This study was performed to assess whether the use of different classes of antihypertensive drugs might influence this association. METHODS:We evaluated risk of uncontrolled BP (BP ≥ 140/90 mmHg ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32834e1eda
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Comprehensive studies have confirmed that particulate matter air pollution could trigger myocardial infarction, heart failure and reduce heart rate variability; however, its effect on blood pressure (BP) remains controversial. Therefore, we did a systematic review and meta-analysis to investigate the associa...
journal_title:Journal of hypertension
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HJH.0000000000000342
更新日期:2014-11-01 00:00:00
abstract::Current opinions on the relationships between erythrocyte sodium-lithium countertransport kinetics and primary hypertension, hyperlipidaemia and diabetic nephropathy are reviewed. Problems associated with the assay are analysed. Some possible mechanisms that could modify the kinetics of ion exchange are examined. The ...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/00004872-199816010-00002
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002016
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Blood pressure management is a key issue among patients with coronary heart disease (CHD). The present study aimed to identify particular patient groups that may need to be specifically targeted in secondary prevention of CHD. METHODS:EUROASPIRE III is a cross-sectional study conducted in 2006-2007 among pa...
journal_title:Journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1097/HJH.0b013e328348efa7
更新日期:2011-08-01 00:00:00
abstract::: The aim of the current article is to review the current evidence on the role of morning blood pressure (BP) in the management of hypertension. Morning BP surge had been and will continue to be a hot topic of hypertension research. However, more evidence is needed to prove its clinical usefulness in the management of...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:10.1097/HJH.0000000000001379
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:A previous history of hypertension is overrepresented among patients with ischaemic heart disease. The present study aims at describing the influence of a previous history of hypertension upon the prognosis among patients hospitalized due to acute myocardial infarction. DESIGN:Patients were followed for 1 y...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199210000-00022
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypert...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001218
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:The present study was designed to investigate the effect of nicardipine administration upon systolic blood pressure (SBP) and cardiac hypertrophy in spontaneously hypertensive rats (SHR). DESIGN:SBP, heart: and left ventricle: body weight ratios, the cross-sectional area of cardiocytes, and the ultrastructur...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199206000-00002
更新日期:1992-06-01 00:00:00