Co-operative binding assay for the characterization of mGlu4 allosteric modulators.

abstract：:Rat hearts were labelled with [3H]norepinephrine in vivo. Slices of ventricles were prepared, preincubated in Krebs-HCO3 medium (KRB), and then incubated in a Na+-deficient, choline+-Krebs HCO3 (Ch+-Ca2+). The choline+-Krebs HCO3 medium induced a delayed neurosecretion which could be inhibited by either one of the blo...

journal_title：Neuropharmacology

authors： Bogdanski DF

更新日期：1985-01-01 00:00:00

abstract：:How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated i...

journal_title：Neuropharmacology

authors： Auerbach A

更新日期：2015-09-01 00:00:00

abstract：:The dopaminergic receptors of planaria have been studied with pharmacological and biochemical criteria. Dopamine D1 selective agonists (CY 208243 (10 micrograms/ml) and SKF 38393 (10 micrograms/ml] induced in planaria typical screw-like hyperkinesias, that were inhibited by a D1 antagonist (SCH 23390 (10 micrograms/ml...

journal_title：Neuropharmacology

authors： Venturini G,Stocchi F,Margotta V,Ruggieri S,Bravi D,Bellantuono P,Palladini G

更新日期：1989-12-01 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slice...

journal_title：Neuropharmacology

authors： Bourne JN,Kirov SA,Sorra KE,Harris KM

更新日期：2007-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and cholinergic defect are widely thought to be the underlying mechanism of learning and memory impairment. Geniposide, which is the main active component of the tradit...

journal_title：Neuropharmacology

authors： Zhao C,Zhang H,Li H,Lv C,Liu X,Li Z,Xin W,Wang Y,Zhang W

更新日期：2017-04-01 00:00:00

abstract：:Here, we define a protophenotype as an endophenotype that has been conserved during evolution. Social feeding in Caenorhabditis elegans may be an example of a protophenotype related to asociality in schizophrenia. It is regulated by the highly conserved neuropeptide Y receptor, NPR-1, and we speculated that social fee...

journal_title：Neuropharmacology

authors： Dwyer DS,Awatramani P,Thakur R,Seeni R,Aamodt EJ

更新日期：2015-05-01 00:00:00

abstract：:Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hyp...

journal_title：Neuropharmacology

authors： Benarroch EE,Balda MS,Finkielman S,Nahmod VE

更新日期：1983-01-01 00:00:00

abstract：:Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study aims to investigate the possible link between σ(1) receptors and MAPKs...

journal_title：Neuropharmacology

authors： Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

更新日期：2010-11-01 00:00:00

abstract：:Neurons in thalamic midline and paraventricular nuclei (PVT) display a unique slow afterhyperpolarizing potential (sAHP) following the low threshold spike (LTS) generated by activation of their low voltage Ca(2+) channels. We evaluated the conductances underlying this sAHP using whole-cell patch-clamp recordings in ra...

journal_title：Neuropharmacology

authors： Kolaj M,Zhang L,Renaud LP

更新日期：2014-11-01 00:00:00

abstract：:Disruption of reproductive function is a hallmark of abuse of anabolic androgenic steroids (AAS) in female subjects. To understand the central actions of AAS, patch clamp recordings were made in estrous, diestrous and AAS-treated mice from gonadotropin releasing hormone (GnRH) neurons, neurons in the medial preoptic a...

journal_title：Neuropharmacology

authors： Penatti CA,Oberlander JG,Davis MC,Porter DM,Henderson LP

更新日期：2011-09-01 00:00:00

abstract：:Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we inve...

journal_title：Neuropharmacology

authors： Vadnie CA,Hinton DJ,Choi S,Choi Y,Ruby CL,Oliveros A,Prieto ML,Park JH,Choi DS

更新日期：2014-10-01 00:00:00

abstract：:Intraventricular administration of substance P (SP), of the heptapeptide SP5-11 and of DiMe-C7, a stable analogue of SP5-11 induced locomotor activation in rats and in mice. The activating effect of substance P was longer-lasting in mice than in rats, whereas the effect of the two heptapeptides appears to be more mark...

journal_title：Neuropharmacology

authors： Naranjo JR,Del Rio J

更新日期：1984-10-01 00:00:00

abstract：:Slob modulates the activity of the Drosophila Slowpoke calcium-dependent potassium channel (dSlo) via its direct binding to the channel. To characterize the molecular detail of the protein-protein interaction between Slob and dSlo, we constructed a series of Slob mutants that are progressively truncated at either the ...

journal_title：Neuropharmacology

authors： Zhou Y,Fei H,Levitan IB

更新日期：2003-11-01 00:00:00

abstract：:A study has been undertaken to identify the category of receptors mediating the inhibitory effects of adenosine on evoked activity in slices of olfactory cortex in the rat. The approach has been to measure the relative potencies of adenosine and a range of structural analogues [2-chloroadenosine, 2' deoxyadenosine, cy...

journal_title：Neuropharmacology

authors： Collins GG,Anson J

更新日期：1985-11-01 00:00:00

abstract：:The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic syndromes. Besides their immunosuppressive action, corticosteroids may directly facilitate transmitte...

journal_title：Neuropharmacology

authors： Oliveira L,Costa AC,Noronha-Matos JB,Silva I,Cavalcante WL,Timóteo MA,Corrado AP,Dal Belo CA,Ambiel CR,Alves-do-Prado W,Correia-de-Sá P

更新日期：2015-02-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordi...

journal_title：Neuropharmacology

authors： Rei N,Rombo DM,Ferreira MF,Baqi Y,Müller CE,Ribeiro JA,Sebastião AM,Vaz SH

更新日期：2020-07-01 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the preferential dopamine D3 receptor agonists, PD128,907 (0.16 mg/kg, i.p.) and 7-OH-DPAT (0.16 mg/kg, i.p.). PD128,907 and 7-OH-DPAT showed "full" (> or = 80%) and mutual generalization. Chemically-diverse, preferential D3 versus D2 agonists, ...

journal_title：Neuropharmacology

authors： Millan MJ,Girardon S,Monneyron S,Dekeyne A

更新日期：2000-02-14 00:00:00

abstract：:The mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonergic (5-HT) toxicity remain unclear. It has been suggested that MDMA depletes 5-HT by increasing brain tyrosine levels, which via non-enzymatic hydroxylation leads to DA-derived free radical formation. Because this hypothesis assumes th...

journal_title：Neuropharmacology

authors： Goñi-Allo B,Puerta E,Mathúna BO,Hervias I,Lasheras B,de la Torre R,Aguirre N

更新日期：2008-04-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. ...

journal_title：Neuropharmacology

authors： Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

更新日期：2011-12-01 00:00:00

abstract：:In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice. Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days. Control...

journal_title：Neuropharmacology

authors： Costa R,Motta EM,Manjavachi MN,Cola M,Calixto JB

更新日期：2012-10-01 00:00:00

abstract：:YM992, (S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride, exhibited the biochemical profile of a selective serotonin (5-HT) reuptake inhibitor (SSRI) with 5-HT2A receptor antagonistic activity. YM922 showed the same high affinity as fluoxetine against the 5-HT reuptake site (Ki = 21 nM) and a similar...

journal_title：Neuropharmacology

authors： Hatanaka K,Nomura T,Hidaka K,Takeuchi H,Yatsugi S,Fujii M,Yamaguchi T

更新日期：1996-01-01 00:00:00

abstract：:Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs, such as selective 5-HT reuptake inhibitors (SSRI) and certain MAO inhibitors (MAOI). In the present study we have used in vivo microdialysis to test this hypoth...

journal_title：Neuropharmacology

authors： Hjorth S,Auerbach SB

更新日期：1994-03-01 00:00:00

abstract：:Several lines of evidence suggest a tight functional coupling between N-methyl-D-aspartate (NMDA) and phencyclidine (PCP) receptors. The effects of PCP receptor agonists (PCP, dexoxadrol, ketamine and MK-801) and NMDA receptor antagonists, cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS-19755) and 3-(2-carboxy...

journal_title：Neuropharmacology

authors： Rao TS,Kim HS,Lehmann J,Martin LL,Wood PL

更新日期：1990-03-01 00:00:00

abstract：:Glutamatergic neurotransmission in the CNS plays a predominant role in learning and memory. While NMDA receptors have been extensively studied, less is known about the involvement of group I metabotropic glutamate receptors in this area. The purpose of the present study was to evaluate the contribution of mGluR1 and m...

journal_title：Neuropharmacology

authors： Gravius A,Barberi C,Schäfer D,Schmidt WJ,Danysz W

更新日期：2006-12-01 00:00:00

abstract：:The information processing at central synapses is mediated not only by homosynaptic transmission with direct synaptic connections but also by heterosynaptic interactions between distinct synaptic inputs. Using rat brain slices and whole-cell recordings this study aimed to examine the roles of GABA(B) receptors in syna...

journal_title：Neuropharmacology

authors： Yamada J,Saitow F,Satake S,Kiyohara T,Konishi S

更新日期：1999-11-01 00:00:00

abstract：:In slices of the hypothalamus of the rat, prelabelled with [3H]5-hydroxytryptamine ([3H]5-HT), dihydroergocristine (DHEC) decreased in a concentration-dependent manner (0.01-1 microM) the release of [3H]transmitter elicited by stimulation. In the presence of phentolamine (1 microM), sulpiride (1 microM), atropine (1 m...

journal_title：Neuropharmacology

authors： Moret C,Briley M

更新日期：1986-02-01 00:00:00

abstract：:The mechanisms underlying lateralization and progression of motor symptoms from unilateral to bilateral in Parkinson's disease (PD) remain to be elucidated. In addition, the molecular mechanisms involved in levodopa-induced dyskinesias (LIDs) depending on lateralization and disease progression from unilaterally to bil...

journal_title：Neuropharmacology

authors： Marin C,Bonastre M,Mengod G,Cortés R,Rodríguez-Oroz MC

更新日期：2015-10-01 00:00:00