Abstract：
:Faithful replication of DNA is a critical aspect in maintaining genome integrity. DNA polymerases are responsible for replicating DNA, and high-fidelity polymerases do this rapidly and at low error rates. Upon exposure to exogenous or endogenous substances, DNA can become damaged and this can alter the speed and fidelity of a DNA polymerase. In this instance, DNA polymerases are confronted with an obstacle that can result in genomic instability during replication, for example, by nucleotide misinsertion or replication fork collapse. It is important to know how DNA polymerases respond to damaged DNA substrates to understand the mechanism of mutagenesis and chemical carcinogenesis. Single-molecule techniques have helped to improve our current understanding of DNA polymerase-mediated DNA replication, as they enable the dissection of mechanistic details that can otherwise be lost in ensemble-averaged experiments. These techniques have also been used to gain a deeper understanding of how single DNA polymerases behave at the site of the damage in a DNA substrate. In this review, we evaluate single-molecule studies that have examined the interaction between DNA polymerases and damaged sites on a DNA template.
journal_name
Chem Res Toxicoljournal_title
Chemical research in toxicologyauthors
Gahlon HL,Romano LJ,Rueda Ddoi
10.1021/acs.chemrestox.7b00224subject
Has Abstractpub_date
2017-11-20 00:00:00pages
1972-1983issue
11eissn
0893-228Xissn
1520-5010journal_volume
30pub_type
杂志文章,评审abstract：:It is well-known that aromatic diamino-, dihydroxy-, and amino-hydroxy compounds, with NH(2) and OH groups in ortho- or para-positions relative to each other, are strong skin sensitizers. In this paper, we analyze published potency and cross-reactivity data, whereby animals sensitized to one of these compounds are cha...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx9000336
更新日期：2009-09-01 00:00:00
abstract：:Evidence from laboratory studies and clinical trials suggests that plant-derived polyphenolic compounds such as curcumin, resveratrol, or phloretin might be useful in the treatment of certain diseases (e.g., Alzheimer's disease) and acute tissue injury states (e.g., spinal cord trauma). However, despite this potential...
journal_title：Chemical research in toxicology
pub_type： 杂志文章,评审
doi：10.1021/acs.chemrestox.6b00300
更新日期：2016-12-19 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx300437x
更新日期：2013-01-18 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00048a001
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx050136g
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pub_type： 杂志文章
doi：10.1021/acs.chemrestox.5b00398
更新日期：2016-06-20 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx000053u
更新日期：2000-07-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx0002435
更新日期：2001-06-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx4003963
更新日期：2014-04-21 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx2002178
更新日期：2011-11-21 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章,评审
doi：10.1021/tx200373u
更新日期：2012-01-13 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx500051k
更新日期：2014-09-15 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章,评审
doi：10.1021/acs.chemrestox.9b00335
更新日期：2020-01-21 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.6b00125
更新日期：2016-07-18 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00038a004
更新日期：1994-03-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00042a008
更新日期：1994-11-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2016-05-16 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：1994-09-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2014-08-18 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx0001272
更新日期：2000-12-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
abstract：:5'-d(CCTATAGATATCC) was reacted with each syn-enantiomer of trans-7,8-dihydroxy 9,10-epoxy 7,8,9,10-tetrahydrobenzo[a]pyrene (syn-BPDE). The (-)-enantiomer yielded one dominating adduct, whereas the (+)-enantiomer resulted in two major adducts. As indicated by optical spectroscopic methods, the major adduct derived fr...
journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
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更新日期：2015-03-16 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/acs.chemrestox.8b00371
更新日期：2019-04-15 00:00:00
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx00009a006
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journal_title：Chemical research in toxicology
pub_type： 杂志文章
doi：10.1021/tx5000409
更新日期：2014-06-16 00:00:00
