Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.

abstract：:The process of disinfecting drinking water inadvertently leads to the formation of numerous disinfection byproducts (DBPs). Some of these are mutagenic, genotoxic, teratogenic, and cytotoxic, as well as potentially carcinogenic both in vivo and in vitro. We investigated the in vitro biological activity of five DBPs: t...

journal_title：Chemical research in toxicology

authors： Procházka E,Escher BI,Plewa MJ,Leusch FD

更新日期：2015-10-19 00:00:00

abstract：:The perfluorinated carboxylic acid, perfluoro-n-decanoic acid (PFDA), is a known peroxisome proliferator which displays toxicity in rodents. Using a paired-tracer first-pass extraction technique, the effect of PFDA on hepatic glucose transport was determined in the isolated perfused rat liver. In brief, livers isolate...

journal_title：Chemical research in toxicology

authors： Goecke-Flora CM,Wyman JF,Jarnot BM,Reo NV

更新日期：1995-01-01 00:00:00

abstract：:The mechanism of formation of etheno (epsilon) adducts of nucleic acid bases from 2-haloacetaldehydes is generally assumed to occur via initial Schiff base formation resulting from reaction of the aldehyde with an exocyclic amine. We recently revised the 1H NMR assignments of the epsilon protons of 1,N2-epsilon-Guo (G...

journal_title：Chemical research in toxicology

authors： Guengerich FP,Persmark M

更新日期：1994-03-01 00:00:00

abstract：:Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various pathophysiological liver diseases and induced by structurally variable hepatotoxic chemicals. A putative common feature for all of these conditions is altered cellular redox status. Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor that is p...

journal_title：Chemical research in toxicology

authors： Lämsä V,Levonen AL,Leinonen H,Ylä-Herttuala S,Yamamoto M,Hakkola J

更新日期：2010-05-17 00:00:00

abstract：:Spin adducts are observed when the unfiltered smoke produced during the aerobic pyrolysis of perfluoro polymers (PFP) is bubbled through a solution of the ESR spin trap alpha-phenyl-N-tert-butylnitrone (PBN). The spin adducts include those from an oxy radical and the fluorine atom, and in addition the spin trap is oxi...

journal_title：Chemical research in toxicology

authors： Lachocki TM,Nuggehalli SK,Scherer KV,Church DF,Pryor WA

更新日期：1989-05-01 00:00:00

abstract：:To reveal the roles of Y family DNA polymerases in the mutagenesis induced by oxidatively damaged DNA precursors, 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dGTP (8-OH-dGTP) were introduced into Escherichia coli strains deficient in the Y family polymerases, DNA polymerase IV (pol IV, encoded by the dinB gene) and DNA p...

journal_title：Chemical research in toxicology

authors： Satou K,Yamada M,Nohmi T,Harashima H,Kamiya H

更新日期：2005-08-01 00:00:00

abstract：:Acrolein is a highly toxic environmental pollutant that readily alkylates the epsilon-amino group of lysine residues in proteins. In model systems, such chemistry involves sequential addition of two acrolein molecules to a given nitrogen, forming bis-Michael-adducted species that undergo aldol condensation and dehydra...

journal_title：Chemical research in toxicology

authors： Kaminskas LM,Pyke SM,Burcham PC

更新日期：2005-11-01 00:00:00

abstract：:Interstrand cross-links are minor components of the collection of products formed in DNA by ionizing radiation. Through their formation by other damaging agents, it is known that interstrand cross-links exert significant effects on replication and transcription. The structures of DNA interstrand cross-links produced a...

journal_title：Chemical research in toxicology

authors： Ding H,Greenberg MM

更新日期：2007-11-01 00:00:00

abstract：:Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. Many studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) in neopla...

journal_title：Chemical research in toxicology

authors： Chen CC,Cheng YY,Chen SC,Tuan YF,Chen YJ,Chen CY,Chen LC

更新日期：2012-03-19 00:00:00

abstract：:A methodology called quantitative component analysis of mixtures (QCAM) was used to analyze an existing set of product formulation data to determine if the irritating ingredients in the mixtures could be identified. Eye irritation scores, based on a rat model, for 18 mixtures having a composite total of 37 components,...

journal_title：Chemical research in toxicology

authors： Patel HC,Duca JS,Hopfinger AJ,Glendening CD,Thompson ED

更新日期：1999-11-01 00:00:00

abstract：:By the action of UVA light, fluphenazine reacted with nucleophiles through a mechanism involving defluorination of its trifluoromethyl group, giving rise to carboxylic acid derivatives that were easily detected by electrospray mass spectrometry. This photoreaction took place with alcohols, sulphydryls, and amines. Whe...

journal_title：Chemical research in toxicology

authors： Caffieri S,Miolo G,Seraglia R,Dalzoppo D,Toma FM,van Henegouwen GM

更新日期：2007-10-01 00:00:00

abstract：:Senescence, which is irreversible cell cycle arrest, is induced by various types of DNA damage, including genotoxic stress. Senescent cells show dysregulation of tumor suppressor genes and other regulators of cellular proliferation. Activating transcription factor 3 (ATF3) plays a pleiotropic role in biological proces...

journal_title：Chemical research in toxicology

authors： Kim KH,Park B,Rhee DK,Pyo S

更新日期：2015-01-20 00:00:00

abstract：:The binding conformations of single anti- and syn-BPDE-N2-dG adducts in oligonucleotides of varying base composition have been studied by induced circular dichroism (ICD) and light absorption spectroscopy. The sign of the ICD in single-stranded oligonucleotide adducts correlates with the absolute configuration of the ...

journal_title：Chemical research in toxicology

authors： Pradhan P,Jernström B,Seidel A,Nordén B,Gräslund A

更新日期：1999-05-01 00:00:00

abstract：:2-(Glutathion-S-yl)-1,4-benzoquinone was found to be remarkably unstable in phosphate buffer (pH 7.4) even in the absence of oxygen. Intramolecular addition of the alpha-amino group of the glutamate residue to the quinone ring yielded ultimately 2,3-(glutathion-N, S-yl)-1,4-benzoquinone and 2,6-(glutathion-N,S-yl)-1,4...

journal_title：Chemical research in toxicology

authors： Alt C,Eyer P

更新日期：1998-10-01 00:00:00

abstract：:In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborati...

journal_title：Chemical research in toxicology

authors： Fry RC,Addo KA,Bell TA,Douillet C,Martin E,Stýblo M,Pardo-Manuel de Villena F

更新日期：2019-08-19 00:00:00

abstract：:Amyloid-β plaques and oxidative stress are the major hallmarks of Alzheimer's disease. Our previous study found that the heme-Aβ complex enhanced the catalytic effect of free heme on protein tyrosine nitration in the presence of hydrogen peroxide (H2O2) and nitrite (NO2-). Y10 in Aβ could be the first target to be nit...

journal_title：Chemical research in toxicology

authors： Zhao J,Wu J,Yang Z,Li H,Gao Z

更新日期：2017-04-17 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed during the cooking of meats and poultry. PhIP is a carcinogen in rodents and a potential human carcinogen. Several short-term biomarkers of PhIP have been established for human biomonitoring, but validated long-term ...

journal_title：Chemical research in toxicology

authors： Peng L,Turesky RJ

更新日期：2011-11-21 00:00:00

abstract：:The first method for generating (*)NO and O(2)(*)(-) at any known, constant ratio has been developed. Spermine NONOate and di(4-carboxybenzyl)hyponitrite decay with first-order kinetics and exactly equal rate constants (half-lives of 80 min) at 37 degrees C and pH 7.5 to give 200 and 40 mol % (*)NO and O(2)(*)(-), res...

journal_title：Chemical research in toxicology

authors： Hodges GR,Marwaha J,Paul T,Ingold KU

更新日期：2000-12-01 00:00:00

abstract：:Iron in iron overload disease is present as non-transferrin-bound iron, consisting of iron, citrate, and albumin. We investigated the redox properties of iron citrate by electrochemistry, by the kinetics of its reaction with ascorbate, by ESR, and by analyzing the products of reactions of ascorbate with iron citrate c...

journal_title：Chemical research in toxicology

authors： Adam FI,Bounds PL,Kissner R,Koppenol WH

更新日期：2015-04-20 00:00:00

abstract：:In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds for which published values of the observed binding affinity (K(i)) are available. A correlation between BE and pK(i) was evident (r(2) = 0.50) for the entire da...

journal_title：Chemical research in toxicology

authors： Ai N,DeLisle RK,Yu SJ,Welsh WJ

更新日期：2003-12-01 00:00:00

abstract：:Nickel(II) compounds are established human carcinogens, but the molecular mechanisms underlying their activity are only partially known. One mechanism may include mediation by nickel of promutagenic oxidative DNA damage that depends on Ni(II) binding to chromatin. To characterize such binding at the histone moiety of ...

journal_title：Chemical research in toxicology

authors： Bal W,Lukszo J,Jezowska-Bojczuk M,Kasprzak KS

更新日期：1995-07-01 00:00:00

abstract：:Induction of Phase II enzymes of the [Ah] gene battery by L-buthionine (S,R)-sulfoximine (BSO) and other agents was examined in mouse hepatoma Hepa-1c1c7 cells. BSO, a nonelectrophilic inhibitor of gamma-glutamylcysteine synthetase (GCS), is routinely used to examine the toxicological implications of GSH depletion. Ex...

journal_title：Chemical research in toxicology

authors： Shertzer HG,Vasiliou V,Liu RM,Tabor MW,Nebert DW

更新日期：1995-04-01 00:00:00

abstract：:Glyoxal is generated endogenously from the degradation of glucose and the oxidation of carbohydrates, lipids, and the 2-deoxyribose moieties of DNA. Glyoxal is also widely used in industry and is present in cigarette smoke and food. Glyoxal can conjugate with nucleobases and proteins to give advanced glycation end pro...

journal_title：Chemical research in toxicology

authors： Wang H,Cao H,Wang Y

更新日期：2010-01-01 00:00:00

abstract：:This study was conducted to investigate the protein adducts with pesticides in a cohort of 172 factory workers that were exposed to a mixture of pesticides. The 35 samples showing considerable variation in biochemical parameters, i.e., butyrylcholinestrase (BChE), serum glutamic pyruvic transaminase (SGPT), serum glut...

journal_title：Chemical research in toxicology

authors： Rehman T,Khan MM,Shad MA,Hussain M,Oyler BL,Goo YA,Goodlett DR

更新日期：2016-10-17 00:00:00

abstract：:Drug-induced myocardial infarction (DIMI) is one of the most serious adverse drug effects that often lead to death. Therefore, the identification of DIMI at the early stages of drug development is essential. For this purpose, the in vitro testing and in silico prediction of interactions between drug-like substances an...

journal_title：Chemical research in toxicology

authors： Ivanov SM,Lagunin AA,Pogodin PV,Filimonov DA,Poroikov VV

更新日期：2014-07-21 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, the cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation, and proteasomal degradation. During hypoxia, degradation decreases, and its intracellular leve...

journal_title：Chemical research in toxicology

authors： Chowdhury R,Godoy LC,Thiantanawat A,Trudel LJ,Deen WM,Wogan GN

更新日期：2012-10-15 00:00:00

abstract：:Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present study, we screened the potential estrogenicity of chemicals via thei...

journal_title：Chemical research in toxicology

authors： Markell LK,Mingoia RT,Peterson HM,Yao J,Waters SM,Finn JP,Nabb DL,Han X

更新日期：2014-08-18 00:00:00

abstract：:Previous reports indicate that 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine (BMTP), the benzyl analogue of the Parkinsonian inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is not neurotoxic in the C-57 black mouse even when administered at a dose 10 times greater than the dose of MPTP required...

journal_title：Chemical research in toxicology

authors： Naiman N,Rollema H,Johnson E,Castagnoli N Jr

更新日期：1990-03-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated that a high reactive metabolite of PCB, namely PCB29-...

journal_title：Chemical research in toxicology

authors： Dong W,Zhu Q,Yang B,Qin Q,Wang Y,Xia X,Zhu X,Liu Z,Song E,Song Y

更新日期：2019-06-17 00:00:00

abstract：:This study was designed to distinguish and evaluate the contribution of reactive metabolite and reactive oxygen species as the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity. The involvement of reactive oxygen species in the mechanism of in vitro cytotoxicity was examined by the addition...

journal_title：Chemical research in toxicology

authors： Tabatabaei AR,Thies RL,Abbott FS

更新日期：1999-04-01 00:00:00