当前位置： SCI文献检索 > CHEMICAL RESEARCH IN TOXICOLOGY期刊下所有文献 > p,p'-DDE induces apoptosis through the modulation of tumor necrosis factor α in PC12 cells.

p,p'-DDE induces apoptosis through the modulation of tumor necrosis factor α in PC12 cells.

Abstract：

:p,p'-DDE, the main metabolite of DDT, is notorious for its persistent and bioaccumulation. It has detrimental effects on the nervous system, while the mechanism is unclear. We sought to investigate the mechanism of p,p'-DDE-induced neurocytic apoptosis in PC12 cells by cytoflow and screen the potential target gene by microarray and ELISA. Co-incubation with antagonist and SiRNA were applied to confirm the effect of the selected molecular. Results were also confirmed in zebrafish embryo. Results showed that p,p'-DDE induced apoptosis in PC12 cells at a concentration of ≥2 × 10(-5) mol/L. Microarray results indicate that the TNF family plays a key role in p,p'-DDE-induced apoptosis among 84-apoptotic genes. In particular, the protein level of TNFα increased 4-fold. When incubated with TNFα antibody (infliximab), the number of apoptotic cells attenuated by 50%, and both activities of caspases 8 and 9 decreased. SiRNA silencing of TNFα showed similar trends. Furthermore, p,p'-DDE induced neuronal apoptosis in zebrafish embryos in a dose-dependent manner.This effect was partially reversed by infliximab, too. Overall, the present study herein indicated that the TNFα signaling pathway is involved in p,p'-DDE-induced neurocyte apoptosis. These data could be expanded to other cases of OCP-induced apoptosis and would support the need for scientific intervention to address the neurotoxicity of these chemicals.

journal_name

Chem Res Toxicol

journal_title

Chemical research in toxicology

authors

Wang C,Zhang Q,Qian Y,Zhao M

doi

10.1021/tx4003963

subject

Has Abstract

pub_date

2014-04-21 00:00:00

pages

507-13

issue

4

eissn

0893-228X

issn

1520-5010

journal_volume

27

pub_type

杂志文章

相关文献

CHEMICAL RESEARCH IN TOXICOLOGY文献大全
  • Comparison of Free Radical Levels in the Aerosol from Conventional Cigarettes, Electronic Cigarettes, and Heat-Not-Burn Tobacco Products.

    abstract：:Aerosols from electronic cigarettes and heat-not-burn tobacco products have been found to contain lower levels of almost all compounds from the list of Harmful and Potentially Harmful Constituents known to be present in tobacco products and tobacco smoke than smoke from conventional cigarettes. Free radicals, which al...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.9b00085

    authors： Shein M,Jeschke G

    更新日期：2019-06-17 00:00:00

  • Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice.

    abstract：:Tetrandrine, a bisbenzylisoquinoline alkaloid, has demonstrated promising pharmacologic activities. The alkaloid has a great potential for clinical use, so a careful, thorough toxicity evaluation of the alkaloid is required. In the present study, 24 h acute toxicity of tetrandrine was evaluated in CD-1 mice. Single in...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx200290s

    authors： Jin H,Li L,Zhong D,Liu J,Chen X,Zheng J

    更新日期：2011-12-19 00:00:00

  • Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis.

    abstract：:Furan has been found in a number of heated food items and is carcinogenic in the liver of rats and mice. Estimates of human exposure on the basis of concentrations measured in food are not reliable because of the volatility of furan. A biomarker approach is therefore indicated. We searched for metabolites excreted in ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx7004212

    authors： Kellert M,Wagner S,Lutz U,Lutz WK

    更新日期：2008-03-01 00:00:00

  • The Multiple Biological Targets of Hops and Bioactive Compounds.

    abstract：:Botanical dietary supplements for women's health are increasingly popular. Older women tend to take botanical supplements such as hops as natural alternatives to traditional hormone therapy to relieve menopausal symptoms. Especially extracts from spent hops, the plant material remaining after beer brewing, are enriche...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/acs.chemrestox.8b00345

    authors： Bolton JL,Dunlap TL,Hajirahimkhan A,Mbachu O,Chen SN,Chadwick L,Nikolic D,van Breemen RB,Pauli GF,Dietz BM

    更新日期：2019-02-18 00:00:00

  • Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

    abstract：:Exposure to the tobacco-related nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine is carcinogenic to humans. Metabolic activation of NNK leads to the formation of DNA adducts, which play a critical role in NNK carcinogenesis. Adducts specific to NNK result from covalent linkag...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx050028u

    authors： Sturla SJ,Scott J,Lao Y,Hecht SS,Villalta PW

    更新日期：2005-06-01 00:00:00

  • (5'S)- and (5'R)-5',8-cyclo-2'-deoxyguanosine: mechanistic insights on the 2'-deoxyguanosin-5'-yl radical cyclization.

    abstract：:The two diastereomeric forms (5'S) and (5'R) of 5',8-cyclo-2'-deoxyguanosine have been synthesized and fully characterized. They have been used as references for the investigation of gamma-irradiation of 2'-deoxyguanosine and photolysis of 8-bromo-2'-deoxyguanosine in aqueous solutions. The observed (5'R)/(5'S) ratio ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700282x

    authors： Chatgilialoglu C,Bazzanini R,Jimenez LB,Miranda MA

    更新日期：2007-12-01 00:00:00

  • Tea polyphenol (-)-epigallocatechin-3-gallate: a new trapping agent of reactive dicarbonyl species.

    abstract：:Previous studies have demonstrated that reactive dicarbonyl compounds [e.g., methylglyoxal (MGO) and glyoxal (GO)] irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its subsequent compli...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700190s

    authors： Sang S,Shao X,Bai N,Lo CY,Yang CS,Ho CT

    更新日期：2007-12-01 00:00:00

  • Future of toxicology--iron chelators and differing modes of action and toxicity: the changing face of iron chelation therapy.

    abstract：:Iron (Fe) chelation therapy was initially designed to alleviate the toxic effects of excess Fe evident in Fe-overload diseases. However, the novel toxicological properties of some Fe chelator-metal complexes have shifted appreciable focus to their application in cancer chemotherapy. Redox-inactive Fe chelator complexe...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700039c

    authors： Kalinowski DS,Richardson DR

    更新日期：2007-05-01 00:00:00

  • Bisphenol A activates the Nrf1/2-antioxidant response element pathway in HEK 293 cells.

    abstract：:Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins for baby bottles, liners of canned food, and many other consumer products. Previously, BPA has been shown to reduce the activity of several antioxidant enzymes, which may contribute to oxidative stress. However, the underlying mecha...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx400036v

    authors： Chepelev NL,Enikanolaiye MI,Chepelev LL,Almohaisen A,Chen Q,Scoggan KA,Coughlan MC,Cao XL,Jin X,Willmore WG

    更新日期：2013-03-18 00:00:00

  • Rapid screening of glutathione-trapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisition data mining.

    abstract：:The present study describes a novel integrated approach for rapid analysis of reactive metabolites with a linear ion trap mass spectrometer (LTQ). In this approach, an isotope pattern-dependent scanning method was applied to the data acquisition of glutathione (GSH)-trapped reactive metabolites. Recorded full-scan MS ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx8001115

    authors： Ma L,Wen B,Ruan Q,Zhu M

    更新日期：2008-07-01 00:00:00

  • AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.

    abstract：:Carcinogens induce complex transcriptional responses in cells that may hold key mechanistic information. Benzo(a)pyrene (BaP) modulation of transcription may occur through the activation of the aryl hydrocarbon receptor (AHR) or through responses to DNA damage. To characterize further the expression profiles induced b...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700252n

    authors： Hockley SL,Arlt VM,Brewer D,Te Poele R,Workman P,Giddings I,Phillips DH

    更新日期：2007-12-01 00:00:00

  • Chalcone inhibition of anthracycline secondary alcohol metabolite formation in rabbit and human heart cytosol.

    abstract：:Antineoplastic therapy with anthracyclines like doxorubicin (DOX) and daunorubicin (DNR) is limited by the possible development of a dose-related cardiomyopathy. Secondary alcohol metabolites like doxorubicinol (DOXol) and daunorubicinol (DNRol), formed by cytoplasmic two-electron reductases, have been implicated as p...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx060159a

    authors： Silvestrini A,Meucci E,Vitali A,Giardina B,Mordente A

    更新日期：2006-11-01 00:00:00

  • Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay.

    abstract：:A newly developed recombinant yeast strain, in which the human estrogen receptor has been stably integrated into the genome of the yeast, was used to gain information on the estrogenic activity of a large series of dietary flavonoids. Among 23 flavonoids investigated, 8 were found to markedly stimulate the transcripti...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx970170y

    authors： Breinholt V,Larsen JC

    更新日期：1998-06-01 00:00:00

  • Bisphenol A increases BeWo trophoblast survival in stress-induced paradigms through regulation of oxidative stress and apoptosis.

    abstract：:Bisphenol A (BPA) is ubiquitous in the environment and is reported to be present at high concentrations in placental tissue, where its presence raises concerns over its potential to disrupt placental function. This report investigates how BPA interferes with the survival of human choriocarcinoma BeWo cells (a model of...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.5b00093

    authors： Ponniah M,Billett EE,De Girolamo LA

    更新日期：2015-09-21 00:00:00

  • Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.

    abstract：:The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally thought to lead to detoxication of xenobiotics, the reactions can also produce reactive intermediates that can react with cellular macromolecules leadi...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章,评审

    doi：10.1021/tx7002504

    authors： Hollenberg PF,Kent UM,Bumpus NN

    更新日期：2008-01-01 00:00:00

  • Differential cellular responses to protein adducts of naphthoquinone and monocrotaline pyrrole.

    abstract：:Protein-xenobiotic adducts are byproducts of xenobiotic metabolism. While there is a correlation between protein adduction and target organ toxicity, a cause and effect relationship is not often clear. Naphthoquinone (NQ) and monocrotaline pyrrole (MCTP) are two pneumotoxic electrophiles that form covalent adducts wit...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx1002436

    authors： Nakayama Wong LS,Lamé MW,Jones AD,Wilson DW

    更新日期：2010-09-20 00:00:00

  • Mechanism of the N-hydroxylation of primary and secondary amines by cytochrome P450.

    abstract：:Cytochrome P450 enzymes (CYPs) metabolize alkyl- and arylamines, generating several different products. For the primary and secondary amines, some of these reactions result in hydroxylated amines, which may be toxic. Thus, when designing new drugs containing amine groups, it is important to be able to predict if a giv...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500371a

    authors： Seger ST,Rydberg P,Olsen L

    更新日期：2015-04-20 00:00:00

  • Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood.

    abstract：:Inorganic arsenic is a strong carcinogen, possibly by interaction with the telomere length. The aim of the study was to evaluate how chronic arsenic exposure from drinking water as well as the arsenic metabolism efficiency affect the individual telomere length and the expression of telomere-related genes. Two hundred ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx300222t

    authors： Li H,Engström K,Vahter M,Broberg K

    更新日期：2012-11-19 00:00:00

  • Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.

    abstract：:Nuclear magnetic resonance (NMR) spectroscopy has traditionally been considered as an indispensable tool in elucidating structures of metabolites. With the advent of Fourier transform (FT) spectrometers, along with improvements in software and hardware (such as high-field magnets, cryoprobes, versatile pulse sequences...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx800251p

    authors： Espina R,Yu L,Wang J,Tong Z,Vashishtha S,Talaat R,Scatina J,Mutlib A

    更新日期：2009-02-01 00:00:00

  • Regioisomeric synthesis and characteristics of the alpha-hydroxy-1,N(2)-propanodeoxyguanosine.

    abstract：:Acrolein, a known mutagen, undergoes reaction in vitro under physiological conditions with both 2'-deoxyguanosine and native DNA to give rise to exocyclic adducts of the 5,6,7,8-tetrahydropyrimido[1,2-a]purine-10(3H)-one class having a hydroxyl group at either the 6 or the 8 position (these positions are respectively ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx015568f

    authors： Huang Y,Johnson F

    更新日期：2002-02-01 00:00:00

  • Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat.

    abstract：:Previously, we reported a new animal model of an idiosyncratic drug reaction in which nevirapine causes a skin rash in some rats that has characteristics similar to the reaction that occurs in humans. Strong evidence that the reaction is immune-mediated was found; specifically, low-dose pretreatment induced tolerance,...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx0501132

    authors： Shenton JM,Popovic M,Chen J,Masson MJ,Uetrecht JP

    更新日期：2005-12-01 00:00:00

  • Estrogen carcinogenesis: specific identification of estrogen-modified nucleobase in breast tissue from women.

    abstract：:Prolonged exposure to estrogens correlates with an increased risk for breast cancer. One explanation is that estrogen metabolites cause mutations by reacting with DNA, leading to depurination. We describe an extraction procedure and a liquid chromatographic tandem mass spectrometric (LC/MS/MS) assay to detect estrone-...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx8001737

    authors： Zhang Q,Aft RL,Gross ML

    更新日期：2008-08-01 00:00:00

  • Highly galloylated tannin fractions from witch hazel (Hamamelis virginiana) bark: electron transfer capacity, in vitro antioxidant activity, and effects on skin-related cells.

    abstract：:Witch hazel ( Hammamelis virginiana) bark is a rich source of both condensed and hydrolizable oligomeric tannins. From a polyphenolic extract soluble in both ethyl acetate and water, we have generated fractions rich in pyrogallol-containing polyphenols (proanthocyanidins, gallotannins, and gallates). The mixtures were...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700425n

    authors： Touriño S,Lizárraga D,Carreras A,Lorenzo S,Ugartondo V,Mitjans M,Vinardell MP,Juliá L,Cascante M,Torres JL

    更新日期：2008-03-01 00:00:00

  • Identification and characterization of deoxyguanosine adducts of methyl vinyl ketone and ethyl vinyl ketone. Genotoxicity of the ketones in the SOS Chromotest.

    abstract：:The reaction of the alpha, beta-unsaturated ketones methyl vinyl ketone (MVK) and ethyl vinyl ketone (EVK) with nucleosides and 5'-mononucleotides was studied. The genotoxic activity of MVK and EVK in the SOS Chromotest was investigated. Three different types of adducts with deoxyguanosine were found and their structu...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00019a007

    authors： Eder E,Hoffman C,Deininger C

    更新日期：1991-01-01 00:00:00

  • Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal.

    abstract：:Methylglyoxal is a mutagenic bis-electrophile that is produced endogenously from carbohydrate precursors. Methylglyoxal has been reported to induce DNA-protein cross-links (DPCs) in vitro and in cultured cells. Previous work suggests that these cross-links are formed between guanine and either lysine or cysteine side ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx500068v

    authors： Petrova KV,Millsap AD,Stec DF,Rizzo CJ

    更新日期：2014-06-16 00:00:00

  • Fragrance compound geraniol forms contact allergens on air exposure. Identification and quantification of oxidation products and effect on skin sensitization.

    abstract：:Fragrances are common causes of contact allergy. Geraniol (trans-3,7-dimethyl-2,6-octadiene-1-ol) is an important fragrance terpene. It is considered a weak contact allergen and is used for fragrance allergy screening among consecutive dermatitis patients. Analogous to other monoterpenes studied, such as limonene and ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx700017v

    authors： Hagvall L,Bäcktorp C,Svensson S,Nyman G,Börje A,Karlberg AT

    更新日期：2007-05-01 00:00:00

  • Lateral Flow Assessment and Unanticipated Toxicity of Kratom.

    abstract：:The leaves of the Mitragynine speciosia tree (also known as Kratom) have long been chewed, smoked, or brewed into a tea by people in Southeastern Asian countries, such as Malaysia and Thailand. Just this past year, the plant Kratom gained popularity in the United States as a "legal opioid" and scheduling it as a drug ...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.8b00218

    authors： Smith LC,Lin L,Hwang CS,Zhou B,Kubitz DM,Wang H,Janda KD

    更新日期：2019-01-22 00:00:00

  • Magnesium Modulates Doxorubicin Activity through Drug Lysosomal Sequestration and Trafficking.

    abstract：:Magnesium is directly involved in the control of cell growth and survival, but its role in cancer biology and therapy is multifaceted; in particular, it is highly controversial whether magnesium levels can affect therapy outcomes. Here we investigated whether magnesium availability can modulate cellular responses to t...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/acs.chemrestox.5b00478

    authors： Trapani V,Luongo F,Arduini D,Wolf FI

    更新日期：2016-03-21 00:00:00

  • Effects of the peroxisome proliferator perfluoro-n-decanoic acid on hepatic gluconeogenesis and glycogenesis: a 13C NMR investigation.

    abstract：:Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in hepatic [1-13C]glucose and [3-13C]alanine utilization on day 5 posttrea...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx00037a003

    authors： Goecke CM,Jarnot BM,Reo NV

    更新日期：1994-01-01 00:00:00

  • Hydroxyl radical is not the main reactive species involved in the degradation of DNA bases by copper in the presence of hydrogen peroxide.

    abstract：:Copper is an important biological metal that tightly binds to DNA. Its reaction with endogenously generated hydrogen peroxide may thus lead to the formation of DNA damage. To gain insights into the underlying mechanisms, a comparative study of the damage produced within isolated DNA upon exposure to gamma-radiation in...

    journal_title：Chemical research in toxicology

    pub_type： 杂志文章

    doi：10.1021/tx025650q

    authors： Frelon S,Douki T,Favier A,Cadet J

    更新日期：2003-02-01 00:00:00